Development Level

Tchem 30 | 1,598
Tbio 24 | 11,445
Tclin 10 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
preweaning lethality, incomple... 4 | 499
decreased body weight 3 | 161
abnormal bone structure 2 | 187
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased circulating sodium l... 2 | 22
decreased total body fat amoun... 2 | 207
increased circulating free fat... 2 | 20
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal skin condition 1 | 6
abnormal startle reflex 1 | 15
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to o... 1 | 239
increased CD4-positive, alpha ... 1 | 4
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased heart left ventricle... 1 | 4
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
thrombocytopenia 1 | 56

Disease

Carcinoma 50 | 11,493
Cancer 44 | 2,499
ovarian cancer 40 | 8,520
glioblastoma 37 | 5,792
lung cancer 33 | 4,740
osteosarcoma 33 | 7,950
Kidney cancer 25 | 2,613
medulloblastoma, large-cell 25 | 6,241
psoriasis 22 | 6,694
invasive ductal carcinoma 21 | 2,951
interstitial cystitis 20 | 2,312
lung carcinoma 20 | 2,843
Breast cancer 19 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
non-small cell lung cancer 18 | 2,890
Schizophrenia 17 | 1,160
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
adult high grade glioma 16 | 3,801
astrocytoma 16 | 1,146
atypical teratoid / rhabdoid tumor 16 | 5,112
subependymal giant cell astrocytoma 16 | 2,287
Astrocytoma, Pilocytic 15 | 3,081
ependymoma 14 | 4,679
group 3 medulloblastoma 14 | 4,104
group 4 medulloblastoma 14 | 1,855
malignant mesothelioma 14 | 3,232
ulcerative colitis 14 | 1,819
Arthritis 13 | 290
diabetes mellitus 13 | 1,728
juvenile dermatomyositis 13 | 1,187
lung adenocarcinoma 13 | 2,716
primary Sjogren syndrome 13 | 735
tuberculosis 13 | 2,010
Pick disease 12 | 1,894
cutaneous lupus erythematosus 12 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
oligodendroglioma 12 | 2,850
pancreatic cancer 12 | 2,398
Liver Cirrhosis, Experimental 11 | 769
Lung Neoplasms 11 | 232
Multiple myeloma 11 | 1,332
Rheumatoid arthritis 11 | 1,191
Waldenstrons macroglobulinemia 11 | 765
primitive neuroectodermal tumor 11 | 3,035
Alzheimer's disease 10 | 658
Asthma 10 | 385
Breast Neoplasms 10 | 445
Intellectual disability 10 | 1,016
Mammary Neoplasms 10 | 425
Stomach Neoplasms 10 | 300
breast carcinoma 10 | 1,638
colon cancer 10 | 1,478
cystic fibrosis 10 | 1,696
Acquired scoliosis 9 | 281
Cognitive delay 9 | 608
Curvature of spine 9 | 282
Downward slant of palpebral fissure 9 | 158
Dull intelligence 9 | 645
Epilepsy 9 | 792
Global developmental delay 9 | 608
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental and motor retardation 9 | 608
Mental deficiency 9 | 645
Orbital separation excessive 9 | 244
Poor school performance 9 | 645
Short stature 9 | 531
Vascular disease 9 | 319
Bipolar Disorder 8 | 666
Blepharoptosis 8 | 231
Byzanthine arch palate 8 | 194
Carcinoma, Squamous Cell 8 | 110
Cell Transformation, Neoplastic 8 | 97
Concave bridge of nose 8 | 195
Congenital Epicanthus 8 | 177
Cryptorchidism 8 | 296
Depressed nasal bridge 8 | 195
Depressed nasal root/bridge 8 | 195
Down syndrome 8 | 499
Hypoplastic mandible condyle 8 | 275
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Muscle hypotonia 8 | 571
Noonan syndrome 8 | 34
Pectus excavatum 8 | 100
Squamous cell carcinoma 8 | 129
adrenocortical carcinoma 8 | 1,428
pediatric high grade glioma 8 | 1,064
Autosomal recessive predisposition 7 | 1,442
Depressive disorder 7 | 409
Frontal bossing 7 | 157
Hypertrophic Cardiomyopathy 7 | 117
Melanoma 7 | 711
Neck webbing 7 | 35
Parkinson's disease 7 | 392
Seizures 7 | 596
Short neck 7 | 140
Strabismus 7 | 270
Toxic encephalopathy 7 | 141
astrocytic glioma 7 | 2,597

Tissue

Blood and immune system 63 | 16,909
Digestive Tract 63 | 17,369
Endocrine System 63 | 18,159
Female tissues 63 | 17,400
Liver and Pancreas 63 | 16,750
Male tissues 63 | 17,142
Respiratory system 63 | 16,393
Skin and soft tissues 63 | 17,230
Urinary Tract 63 | 16,678
Cardiovascular System 62 | 15,192
Nervous System 62 | 16,725

Target Family

Kinase 25 | 634
Non-IDG 19 | 12,091
Enzyme 14 | 4,145
Transcription Factor 5 | 1,400
GPCR 1 | 408

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 64 | 64
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase Fer FER Tchem Kinase -1.86307 55.4 414
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Nuclear factor of activated T-cells, cytoplasmic 2 NFATC2 Tbio Transcription Factor -2.43207 259.4 365
Linker for activation of T-cells family member 1 LAT Tbio Non-IDG -2.16291 169.4 667
Immunoglobulin heavy constant epsilon IGHE Tclin Non-IDG 0.00000 0
Tyrosine-protein phosphatase non-receptor type 13 PTPN13 Tchem Enzyme -2.23001 181.6 129
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494