Development Level

Tbio 17 | 10,625
Tdark 3 | 7,003
Tchem 2 | 1,890
Tclin 2 | 602

Collection

Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, incomple... 2 | 260
abnormal retina morphology 1 | 100
decreased leukocyte cell numbe... 1 | 54
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired pupillary reflex 1 | 14
increased leukocyte cell numbe... 1 | 37
limb grasping 1 | 35
mydriasis 1 | 9

Disease

Cone dystrophy 14 | 57
Fundus dystrophy 13 | 77
Leber congenital amaurosis 10 | 72
Blindness 9 | 84
Retinitis pigmentosa 9 | 153
Retinal Degeneration 8 | 49
Achromatopsia 6 | 14
osteosarcoma 6 | 7,933
Bradyopsia 5 | 10
Night Blindness 5 | 39
astrocytic glioma 5 | 2,241
glioblastoma 5 | 5,572
pituitary cancer 5 | 1,972
psoriasis 5 | 6,685
Progressive cone dystrophy (without rod involvement) 4 | 4
medulloblastoma 4 | 1,524
medulloblastoma, large-cell 4 | 6,234
oligodendroglioma 4 | 2,849
posterior fossa group B ependymoma 4 | 1,530
primitive neuroectodermal tumor 4 | 3,031
Carcinoma 3 | 2,147
Congenital nystagmus 3 | 26
atypical teratoid / rhabdoid tumor 3 | 4,369
cone-rod dystrophy 3 | 56
facioscapulohumeral dystrophy 3 | 286
lung carcinoma 3 | 2,844
pediatric high grade glioma 3 | 2,712
Atrial Fibrillation 2 | 110
Chronic heart failure 2 | 46
Color vision defect 2 | 3
Congenital stationary night blindness 2 | 27
Eye Diseases, Hereditary 2 | 6
Myocardial Perfusion Imaging Adjunct 2 | 25
Obesity 2 | 616
Optic Atrophy, Hereditary, Leber 2 | 14
PERRS Gene 2 | 2
Partial central choroid dystrophy 2 | 12
Platelet Aggregation Inhibition 2 | 22
Prevention of Cerebral Thrombosis 2 | 29
Retinal Dystrophies 2 | 5
adult high grade glioma 2 | 2,148
gastric carcinoma 2 | 832
group 3 medulloblastoma 2 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
ovarian cancer 2 | 8,484
posterior fossa group A ependymoma 2 | 1,511
Achromatopsia 5 1 | 1
Acquired metabolic disease 1 | 267
Alzheimer's disease 1 | 644
Amaurosis congenita of Leber, type 1 1 | 1
Amphetamine-Related Disorders 1 | 74
Blind Vision 1 | 3
Brain Ischemia 1 | 87
CLL/SLL 1 | 2
CONE DYSTROPHY 4 (disorder) 1 | 1
Central areolar choroidal sclerosis 1 | 2
Choroideremia 1 | 13
Cone-Rod Dystrophy 5 1 | 2
Coronary artery disease 1 | 240
Diabetes Mellitus, Non-Insulin-Dependent 1 | 157
Dyskinesia, Drug-Induced 1 | 15
Dyspepsia 1 | 34
Essential Hypertension 1 | 82
Eye disease 1 | 55
Heroin dependence 1 | 30
Hypertension 1 | 287
Hypertensive disease 1 | 193
Irritable bowel syndrome 1 | 59
LEBER CONGENITAL AMAUROSIS 13 1 | 1
LEBER CONGENITAL AMAUROSIS 3 (disorder) 1 | 2
Macular degeneration 1 | 41
Miller Fisher syndrome 1 | 3
Myopia 1 | 99
Night blindness, congenital stationary 1 | 14
Pick disease 1 | 1,893
Psychoses, Substance-Induced 1 | 17
Pyloric stenosis 1 | 9
RETINITIS PIGMENTOSA 48 1 | 1
RETINITIS PIGMENTOSA 53 1 | 1
Refractive error 1 | 43
Retinal Cone Dystrophy 3A 1 | 1
Retinal cone dystrophy 2 1 | 1
Scotoma 1 | 7
Seizures 1 | 95
Stargardt's disease 1 | 5
Vitamin A Deficiency 1 | 5
Weight Gain 1 | 87
active Crohn's disease 1 | 918
atypical teratoid/rhabdoid tumor 1 | 1,095
colon cancer 1 | 1,475
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,988
lung adenocarcinoma 1 | 2,713
non-small cell lung cancer 1 | 2,798
non-small cell lung carcinoma 1 | 413
non-syndromic X-linked intellectual disability 1 | 10
pancreatic cancer 1 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,795
pilocytic astrocytoma 1 | 3,086
primary pancreatic ductal adenocarcinoma 1 | 1,271
subependymal giant cell astrocytoma 1 | 2,287

Tissue

Nervous System 24 | 18,561
Cardiovascular System 23 | 17,958
Digestive Tract 22 | 18,473
Endocrine System 22 | 18,512
Female tissues 22 | 18,647
Liver and Pancreas 22 | 18,136
Skin and soft tissues 22 | 18,115
Urinary Tract 22 | 18,444
Blood and immune system 21 | 17,995
Male tissues 21 | 17,969
Respiratory system 21 | 17,484

Target Family

Enzyme 9 | 4,146
Non-IDG 7 | 11,971
Kinase 4 | 634
Ion Channel 2 | 341
GPCR 1 | 406
Transporter 1 | 473

PathwayCommons: pid Pathway

Visual signal transduction: Co... 24 | 24
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C Tclin Enzyme -1.36465 22.7 78
Arrestin-C ARR3 Tbio Non-IDG -1.92020 78.9 155
Retinal guanylyl cyclase 2 GUCY2F Tbio Kinase -1.03655 7.37 72
Regulator of G-protein signaling 9-binding protein RGS9BP Tbio Non-IDG -1.26317 21.2 10
Retinal guanylyl cyclase 1 GUCY2D Tbio Kinase -2.21858 178.4 196
Guanylyl cyclase-activating protein 2 GUCA1B Tbio Enzyme -1.61434 42.7 96
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H Tclin Enzyme -0.83854 7.12 33
Retinol dehydrogenase 12 RDH12 Tbio Enzyme -1.54113 36.6 48
Rhodopsin kinase GRK7 Tchem Kinase -1.83532 45.2 165
Guanylyl cyclase-activating protein 3 GUCA1C Tdark Enzyme 0.00 1.10 95