Development Level

Tbio 40 | 10,625
Tchem 15 | 1,890
Tclin 7 | 602
Tdark 1 | 7,003

IMPC Phenotype

preweaning lethality, complete... 4 | 633
decreased erythrocyte cell num... 3 | 43
abnormal sleep behavior 2 | 63
decreased body weight 2 | 174
decreased bone mineral density 2 | 126
decreased total body fat amoun... 2 | 186
enlarged heart 2 | 111
increased circulating HDL chol... 2 | 63
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
thrombocytopenia 2 | 46
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal bone mineralization 1 | 55
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal iris morphology 1 | 12
abnormal locomotor activation 1 | 26
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal skin morphology 1 | 23
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
decreased body length 1 | 108
decreased circulating HDL chol... 1 | 77
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating total pr... 1 | 41
decreased effector memory CD8-... 1 | 24
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased prepulse inhibition 1 | 52
decreased startle reflex 1 | 48
dilated heart left ventricle 1 | 10
embryonic lethality prior to t... 1 | 187
enlarged epididymis 1 | 27
enlarged spleen 1 | 26
female infertility 1 | 34
hypoactivity 1 | 89
increased aggression 1 | 2
increased blood urea nitrogen ... 1 | 44
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased prepulse inhibition 1 | 21
increased total body fat amoun... 1 | 57
male infertility 1 | 62
preweaning lethality, incomple... 1 | 260
prolonged QRS complex duration 1 | 2
shortened head 1 | 2
small testis 1 | 37

Disease

Cancer 46 | 2,346
psoriasis 42 | 6,685
osteosarcoma 38 | 7,933
ovarian cancer 38 | 8,491
glioblastoma 32 | 5,572
lung cancer 28 | 4,473
medulloblastoma, large-cell 26 | 6,234
malignant mesothelioma 24 | 3,163
subependymal giant cell astrocytoma 23 | 2,287
Breast cancer 21 | 3,098
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,289
non-small cell lung cancer 20 | 2,798
atypical teratoid / rhabdoid tumor 19 | 4,369
ulcerative colitis 19 | 2,087
astrocytoma 18 | 1,493
group 4 medulloblastoma 16 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,988
invasive ductal carcinoma 16 | 2,950
pediatric high grade glioma 16 | 2,712
primitive neuroectodermal tumor 16 | 3,031
cystic fibrosis 15 | 1,670
ductal carcinoma in situ 15 | 1,745
pancreatic cancer 15 | 2,300
pilocytic astrocytoma 15 | 3,086
interstitial cystitis 14 | 2,299
lung adenocarcinoma 14 | 2,714
Carcinoma 13 | 2,147
acute quadriplegic myopathy 13 | 1,157
colon cancer 13 | 1,475
group 3 medulloblastoma 13 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,956
juvenile dermatomyositis 13 | 1,189
lung carcinoma 13 | 2,844
pituitary cancer 13 | 1,972
dermatomyositis 12 | 966
primary pancreatic ductal adenocarcinoma 12 | 1,271
Mammary Neoplasms 11 | 410
Prostatic Neoplasms 11 | 471
nasopharyngeal carcinoma 11 | 1,056
oligodendroglioma 11 | 2,849
Multiple myeloma 10 | 1,327
diabetes mellitus 10 | 1,663
ependymoma 10 | 2,514
tuberculosis 10 | 1,563
breast carcinoma 9 | 1,614
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
sonic hedgehog group medulloblastoma 9 | 1,482
Adenoma 8 | 165
Leukemia, Myelocytic, Acute 8 | 113
Lung Neoplasms 8 | 171
Pick disease 8 | 1,893
Stomach Neoplasms 8 | 282
Waldenstrons macroglobulinemia 8 | 764
acute myeloid leukemia 8 | 785
adrenocortical carcinoma 8 | 1,427
atypical teratoid/rhabdoid tumor 8 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
posterior fossa group A ependymoma 8 | 1,511
Colonic Neoplasms 7 | 126
Duchenne muscular dystrophy 7 | 602
Kidney cancer 7 | 121
Multiple Sclerosis 7 | 498
cutaneous lupus erythematosus 7 | 1,056
esophageal adenocarcinoma 7 | 737
Amyotrophic Lateral Sclerosis 6 | 432
Crohn's disease 6 | 304
Down syndrome 6 | 548
Neoplastic Cell Transformation 6 | 81
Peripheral Neuropathy 6 | 303
Vascular disease 6 | 281
adult high grade glioma 6 | 2,148
non-small cell lung carcinoma 6 | 413
primary Sjogren syndrome 6 | 788
Adenoid Cystic Carcinoma 5 | 99
Alzheimer's disease 5 | 644
Colorectal Neoplasms 5 | 217
Juvenile arthritis 5 | 124
Kidney disease 5 | 397
Liver carcinoma 5 | 217
Neoplasm Metastasis 5 | 138
Obesity 5 | 616
Pancreatic Neoplasm 5 | 79
Rheumatoid Arthritis 5 | 1,170
Squamous cell carcinoma 5 | 96
chronic lymphocytic leukemia 5 | 244
chronic rhinosinusitis 5 | 512
fibroadenoma 5 | 557
gastric cancer 5 | 436
hepatocellular carcinoma 5 | 550
medulloblastoma 5 | 1,524
non primary Sjogren syndrome sicca 5 | 840
ovarian neoplasm 5 | 97
urothelial carcinoma 5 | 318
Endometriosis 4 | 535
Heart disease 4 | 279
aldosterone-producing adenoma 4 | 664
astrocytic glioma 4 | 2,241
gastric carcinoma 4 | 832
non diabetic and post-ischemic heart failure 4 | 200
spina bifida 4 | 1,064

Tissue

Blood and immune system 63 | 17,994
Digestive Tract 62 | 18,472
Endocrine System 62 | 18,511
Female tissues 62 | 18,646
Liver and Pancreas 62 | 18,135
Male tissues 62 | 17,968
Nervous System 62 | 18,560
Respiratory system 62 | 17,483
Skin and soft tissues 62 | 18,114
Urinary Tract 62 | 18,443
Cardiovascular System 61 | 17,957

Target Family

Non-IDG 28 | 11,969
Transcription Factor 21 | 1,400
Enzyme 7 | 4,146
Epigenetic 4 | 242
Kinase 2 | 634
Transporter 1 | 473

PathwayCommons: pid Pathway

Validated targets of C-MYC tra... 63 | 63
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.69372 46.6 95
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.03044 1092.0 356
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.74239 5756.8 1322
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.09050 11730.8 2241
Nuclear transcription factor Y subunit gamma NFYC Tbio Transcription Factor -1.86760 71.7 180
Dickkopf-related protein 1 DKK1 Tchem Non-IDG -2.74198 552.4 624
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -1.31733 6.84 120
Retinoblastoma-like protein 1 RBL1 Tbio Non-IDG -2.61943 376.7 290
Sideroflexin-3 SFXN3 Tdark Non-IDG -0.50060 3.38 88