Development Level

Tbio 52 | 10,625
Tchem 23 | 1,890
Tclin 3 | 602
Tdark 2 | 7,003

IMPC Phenotype

decreased body weight 3 | 174
decreased caudal vertebrae num... 3 | 49
preweaning lethality, complete... 3 | 633
preweaning lethality, incomple... 3 | 260
decreased circulating alkaline... 2 | 41
decreased total body fat amoun... 2 | 186
increased circulating triglyce... 2 | 24
male infertility 2 | 62
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal hair texture 1 | 4
abnormal snout morphology 1 | 18
corneal opacity 1 | 25
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased heart weight 1 | 44
decreased lactate dehydrogenas... 1 | 14
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
female infertility 1 | 34
hydrops fetalis 1 | 22
increased circulating magnesiu... 1 | 10
increased grip strength 1 | 83
increased heart rate 1 | 17
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
microphthalmia 1 | 15
short tibia 1 | 82
shortened RR interval 1 | 19
thrombocytopenia 1 | 46
urinary bladder obstruction 1 | 2

Disease

Cancer 50 | 2,346
ovarian cancer 50 | 8,491
medulloblastoma, large-cell 42 | 6,234
psoriasis 42 | 6,685
osteosarcoma 39 | 7,933
lung cancer 37 | 4,473
glioblastoma 34 | 5,572
atypical teratoid / rhabdoid tumor 24 | 4,369
non-small cell lung cancer 24 | 2,798
lung adenocarcinoma 23 | 2,714
Breast cancer 22 | 3,098
primitive neuroectodermal tumor 22 | 3,031
pediatric high grade glioma 21 | 2,712
oligodendroglioma 20 | 2,849
pancreatic cancer 20 | 2,300
Multiple myeloma 19 | 1,327
invasive ductal carcinoma 19 | 2,950
group 3 medulloblastoma 18 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,289
malignant mesothelioma 18 | 3,163
colon cancer 17 | 1,475
astrocytoma 16 | 1,493
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,988
Waldenstrons macroglobulinemia 15 | 764
ductal carcinoma in situ 15 | 1,745
Mammary Neoplasms 14 | 410
adrenocortical carcinoma 14 | 1,427
diabetes mellitus 14 | 1,663
pilocytic astrocytoma 14 | 3,086
subependymal giant cell astrocytoma 13 | 2,287
ulcerative colitis 13 | 2,087
acute myeloid leukemia 12 | 785
acute quadriplegic myopathy 12 | 1,157
nasopharyngeal carcinoma 12 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
ependymoma 11 | 2,514
interstitial cystitis 11 | 2,299
posterior fossa group A ependymoma 11 | 1,511
sonic hedgehog group medulloblastoma 11 | 1,482
astrocytic glioma 10 | 2,241
cystic fibrosis 10 | 1,670
group 4 medulloblastoma 10 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,956
lung carcinoma 10 | 2,844
Carcinoma 9 | 2,147
IGA Glomerulonephritis 9 | 454
Liver carcinoma 9 | 217
Neurodegenerative disease 9 | 383
Stomach Neoplasms 9 | 282
esophageal adenocarcinoma 9 | 737
gastric carcinoma 9 | 832
non primary Sjogren syndrome sicca 9 | 840
pituitary cancer 9 | 1,972
primary pancreatic ductal adenocarcinoma 9 | 1,271
tuberculosis 9 | 1,563
Colonic Neoplasms 8 | 126
Colorectal Neoplasms 8 | 217
Neoplastic Cell Transformation 8 | 81
Pick disease 8 | 1,893
Prostatic Neoplasms 8 | 471
breast carcinoma 8 | 1,614
dermatomyositis 8 | 966
non-small cell lung carcinoma 8 | 413
pancreatic carcinoma 8 | 567
Atopic dermatitis 7 | 944
HIV Infections 7 | 99
Lung Neoplasms 7 | 171
Neoplasm Metastasis 7 | 138
Rheumatoid Arthritis 7 | 1,170
aldosterone-producing adenoma 7 | 664
Anemia 6 | 252
Bladder Neoplasm 6 | 109
Duchenne muscular dystrophy 6 | 602
Endometriosis 6 | 535
Kidney disease 6 | 397
Vascular disease 6 | 281
atypical teratoid/rhabdoid tumor 6 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 499
juvenile dermatomyositis 6 | 1,189
Adenoma 5 | 165
Alzheimer's disease 5 | 644
Degenerative polyarthritis 5 | 93
Diabetes Mellitus, Experimental 5 | 106
Melanoma 5 | 261
Neoplasm Invasiveness 5 | 127
Neoplastic Syndromes, Hereditary 5 | 48
Osteoporosis 5 | 259
Polycystic Ovary Syndrome 5 | 334
Renal Cell Carcinoma 5 | 199
adult high grade glioma 5 | 2,148
chronic lymphocytic leukemia 5 | 244
cutaneous lupus erythematosus 5 | 1,056
mucosa-associated lymphoid tissue lymphoma 5 | 480
ovarian neoplasm 5 | 97
posterior fossa group B ependymoma 5 | 1,530
primary Sjogren syndrome 5 | 788
Myocardial Ischemia 4 | 169
hepatocellular carcinoma 4 | 550
periodontitis 4 | 269
spina bifida 4 | 1,064

Tissue

Blood and immune system 80 | 17,994
Cardiovascular System 80 | 17,957
Digestive Tract 80 | 18,472
Endocrine System 80 | 18,511
Female tissues 80 | 18,646
Liver and Pancreas 80 | 18,135
Male tissues 80 | 17,968
Nervous System 80 | 18,560
Skin and soft tissues 79 | 18,114
Urinary Tract 79 | 18,443
Respiratory system 78 | 17,483

Target Family

Non-IDG 41 | 11,969
Enzyme 14 | 4,146
Transcription Factor 13 | 1,400
Kinase 6 | 634
Epigenetic 5 | 242
Transporter 1 | 473

PathwayCommons: pid Pathway

Validated targets of C-MYC tra... 80 | 80
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.09050 11730.8 2241
CAD protein CAD Tchem Non-IDG -2.23424 164.6 201
Nucleoside diphosphate kinase A NME1 Tbio Kinase -2.97569 843.2 611
Cell division cycle-associated protein 7 CDCA7 Tbio Non-IDG -1.08490 11.1 67
STAGA complex 65 subunit gamma SUPT7L Tdark Non-IDG -0.44863 2.75 64
Protein lin-28 homolog B LIN28B Tbio Transcription Factor -2.03612 100.0 171
Fos-related antigen 1 FOSL1 Tbio Transcription Factor -2.36131 214.3 211
DNA-binding protein inhibitor ID-2 ID2 Tbio Transcription Factor -2.45973 294.5 249
Killer cell immunoglobulin-like receptor 3DL1 KIR3DL1 Tbio Non-IDG -2.11182 198.8 236
M-phase inducer phosphatase 1 CDC25A Tchem Enzyme -2.45436 266.0 1243