Development Level

Tchem 23 | 1,890
Tbio 21 | 10,625
Tclin 12 | 602

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, incomple... 4 | 260
abnormal behavior 3 | 226
abnormal testis morphology 2 | 30
decreased circulating alanine ... 2 | 53
decreased hematocrit 2 | 25
increased circulating alkaline... 2 | 119
male infertility 2 | 62
preweaning lethality, complete... 2 | 633
small testis 2 | 37
abnormal bone mineralization 1 | 55
abnormal femur morphology 1 | 14
abnormal retina morphology 1 | 100
abnormal seminal vesicle morph... 1 | 47
abnormal spleen morphology 1 | 36
abnormal vocalization 1 | 21
decreased CD4-positive, CD25-p... 1 | 24
decreased NK T cell number 1 | 28
decreased basophil cell number 1 | 11
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 24
decreased circulating insulin ... 1 | 75
decreased circulating phosphat... 1 | 15
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased dendritic cell numbe... 1 | 3
decreased erythrocyte cell num... 1 | 43
decreased hemoglobin content 1 | 53
decreased immature NK cell num... 1 | 1
decreased leukocyte cell numbe... 1 | 54
decreased mature B cell number 1 | 25
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
decreased total body fat amoun... 1 | 186
enlarged spleen 1 | 26
hydrops fetalis 1 | 22
hypoactivity 1 | 89
increased CD4-positive, alpha ... 1 | 15
increased KLRG1-positive NK ce... 1 | 9
increased Ly6C high monocyte n... 1 | 12
increased NK cell number 1 | 19
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating calcium ... 1 | 32
increased circulating iron lev... 1 | 25
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased effector memory CD4-... 1 | 15
increased effector memory CD8-... 1 | 14
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased mature NK cell numbe... 1 | 1
increased monocyte cell number 1 | 27
increased or absent threshold ... 1 | 128
increased plasmacytoid dendrit... 1 | 1
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

osteosarcoma 40 | 7,933
ovarian cancer 32 | 8,491
Cancer 28 | 2,346
medulloblastoma, large-cell 28 | 6,234
glioblastoma 25 | 5,572
psoriasis 25 | 6,685
lung carcinoma 22 | 2,844
lung cancer 21 | 4,473
non-small cell lung cancer 20 | 2,798
ulcerative colitis 19 | 2,087
atypical teratoid / rhabdoid tumor 18 | 4,369
interstitial cystitis 18 | 2,299
pilocytic astrocytoma 17 | 3,086
invasive ductal carcinoma 16 | 2,950
diabetes mellitus 15 | 1,663
subependymal giant cell astrocytoma 15 | 2,287
lung adenocarcinoma 14 | 2,714
oligodendroglioma 14 | 2,849
pediatric high grade glioma 14 | 2,712
primitive neuroectodermal tumor 14 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
malignant mesothelioma 13 | 3,163
Breast cancer 12 | 3,098
astrocytoma 12 | 1,493
group 4 medulloblastoma 12 | 1,875
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
Rheumatoid Arthritis 11 | 1,170
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,956
pancreatic cancer 11 | 2,300
primary Sjogren syndrome 11 | 788
Pick disease 10 | 1,893
cutaneous lupus erythematosus 10 | 1,056
ependymoma 10 | 2,514
Asthma 9 | 349
Blastic phase chronic myeloid leukemia 9 | 58
Carcinoma 9 | 2,147
Chronic Myelocytic Leukemia Accelerated Phase 9 | 59
Hypertension 9 | 293
Kidney disease 9 | 397
Waldenstrons macroglobulinemia 9 | 764
adult high grade glioma 9 | 2,148
Heart disease 8 | 279
Lung disease 8 | 136
cystic fibrosis 8 | 1,670
ductal carcinoma in situ 8 | 1,745
group 3 medulloblastoma 8 | 2,254
medulloblastoma 8 | 1,524
pituitary cancer 8 | 1,972
tuberculosis 8 | 1,563
Cardiomegaly 7 | 66
Cerebrovascular disease 7 | 231
Chronic phase chronic myeloid leukemia 7 | 45
Mammary Neoplasms 7 | 410
Myocardial Ischemia 7 | 169
Obesity 7 | 616
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 7 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 7 | 47
adrenocortical carcinoma 7 | 1,427
colon cancer 7 | 1,475
juvenile dermatomyositis 7 | 1,189
posterior fossa group A ependymoma 7 | 1,511
primary pancreatic ductal adenocarcinoma 7 | 1,271
Allergic rhinitis 6 | 92
Arthritis 6 | 248
Atherosclerosis 6 | 275
Coronary artery disease 6 | 240
Crohn's disease 6 | 304
Hypertensive disease 6 | 193
Multiple myeloma 6 | 1,327
Prostatic Neoplasms 6 | 471
active Crohn's disease 6 | 918
active ulcerative colitis 6 | 477
acute quadriplegic myopathy 6 | 1,157
astrocytic glioma 6 | 2,241
sarcoidosis 6 | 368
Alzheimer's disease 5 | 644
Cardiomyopathies 5 | 90
Diabetes Mellitus, Experimental 5 | 106
Hyperglycemia 5 | 120
Impotence 5 | 45
Metabolic syndrome X 5 | 155
Multiple Sclerosis 5 | 498
Peripheral Neuropathy 5 | 303
Peripheral vascular disease 5 | 90
Stomach Neoplasms 5 | 282
Vascular disease 5 | 281
atypical teratoid/rhabdoid tumor 5 | 1,095
breast carcinoma 5 | 1,614
esophageal adenocarcinoma 5 | 737
mucosa-associated lymphoid tissue lymphoma 5 | 480
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
posterior fossa group B ependymoma 5 | 1,530
spina bifida 5 | 1,064
Cardiovascular Diseases 4 | 50
Diabetes Mellitus, Non-Insulin-Dependent 4 | 161
Hypersensitivity reaction type II disease 4 | 235
Schizophrenia 4 | 503
gastric carcinoma 4 | 832
periodontitis 4 | 269
progressive supranuclear palsy 4 | 674

Tissue

Blood and immune system 56 | 17,994
Cardiovascular System 56 | 17,957
Digestive Tract 56 | 18,472
Female tissues 56 | 18,646
Male tissues 56 | 17,968
Nervous System 56 | 18,560
Respiratory system 56 | 17,483
Urinary Tract 56 | 18,443
Endocrine System 55 | 18,511
Liver and Pancreas 55 | 18,135
Skin and soft tissues 55 | 18,114

Target Family

Kinase 27 | 634
Non-IDG 18 | 11,969
Enzyme 7 | 4,146
GPCR 3 | 408
Transporter 1 | 473

PathwayCommons: pid Pathway

Thromboxane A2 receptor signal... 56 | 56
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E-selectin SELE Tchem Non-IDG -3.43650 2598.8 820
Pro-epidermal growth factor EGF Tbio Non-IDG -3.74596 4837.7 851
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.12987 136.7 95
cGMP-dependent protein kinase 1 PRKG1 Tchem Kinase -2.67695 418.8 220
Ras-related protein Rab-11A RAB11A Tbio Enzyme -2.62399 398.9 288
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.87449 73.5 395
Guanine nucleotide-binding protein G(i) subunit alpha-2 GNAI2 Tbio Non-IDG -1.25323 16.6 188
Phosphoinositide 3-kinase regulatory subunit 6 PIK3R6 Tbio Enzyme 0.00000 66
Intercellular adhesion molecule 1 ICAM1 Tchem Non-IDG -3.94773 8990.1 1781
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.11789 1349.3 1026