Development Level

Tbio 34 | 10,625
Tchem 18 | 1,890
Tclin 1 | 602

IMPC Term

decreased lean body mass 4 | 195
abnormal behavior 3 | 226
decreased bone mineral content 3 | 157
decreased total body fat amoun... 3 | 186
preweaning lethality, complete... 3 | 633
abnormal bone structure 2 | 131
decreased circulating HDL chol... 2 | 77
decreased circulating choleste... 2 | 85
decreased rib number 2 | 59
decreased startle reflex 2 | 48
increased circulating phosphat... 2 | 24
increased heart weight 2 | 37
increased mean corpuscular vol... 2 | 91
preweaning lethality, incomple... 2 | 260
thrombocytopenia 2 | 46
abnormal bone mineralization 1 | 55
abnormal coat/ hair morphology 1 | 18
abnormal eyelid morphology 1 | 6
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 73
abnormal retina morphology 1 | 100
abnormal skin coloration 1 | 18
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal tooth morphology 1 | 24
absent startle reflex 1 | 15
corneal opacity 1 | 25
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased hemoglobin content 1 | 53
decreased lactate dehydrogenas... 1 | 14
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
embryonic lethality prior to t... 1 | 187
hydrops fetalis 1 | 22
hyperactivity 1 | 108
hypoactivity 1 | 89
increased CD8-positive, naive ... 1 | 3
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating potassiu... 1 | 31
increased circulating total pr... 1 | 20
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased or absent threshold ... 1 | 128
increased rib number 1 | 41
increased total body fat amoun... 1 | 57
microcephaly 1 | 3
narrow eye opening 1 | 15
persistence of hyaloid vascula... 1 | 22
thrombocytosis 1 | 23
tremors 1 | 34
trunk curl 1 | 15

Disease

ovarian cancer 40 | 8,492
osteosarcoma 37 | 7,933
Cancer 28 | 2,346
glioblastoma 27 | 5,572
medulloblastoma, large-cell 25 | 6,234
psoriasis 24 | 6,685
atypical teratoid / rhabdoid tumor 23 | 4,369
Breast cancer 16 | 3,099
lung cancer 15 | 4,473
pediatric high grade glioma 14 | 2,712
pilocytic astrocytoma 14 | 3,086
Carcinoma 13 | 2,147
Multiple myeloma 13 | 1,328
lung adenocarcinoma 13 | 2,714
non-small cell lung cancer 13 | 2,798
ependymoma 12 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
invasive ductal carcinoma 12 | 2,950
juvenile dermatomyositis 12 | 1,189
lung carcinoma 12 | 2,844
malignant mesothelioma 12 | 3,163
subependymal giant cell astrocytoma 12 | 2,287
diabetes mellitus 11 | 1,663
group 4 medulloblastoma 11 | 1,875
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
pancreatic cancer 11 | 2,300
Pick disease 10 | 1,893
astrocytic glioma 10 | 2,241
ductal carcinoma in situ 10 | 1,745
oligodendroglioma 10 | 2,849
primary pancreatic ductal adenocarcinoma 10 | 1,271
Kidney disease 9 | 397
acute quadriplegic myopathy 9 | 1,157
cystic fibrosis 9 | 1,670
dermatomyositis 9 | 967
group 3 medulloblastoma 9 | 2,254
primitive neuroectodermal tumor 9 | 3,031
adult high grade glioma 8 | 2,148
interstitial cystitis 8 | 2,299
tuberculosis 8 | 1,563
Pulmonary Fibrosis 7 | 66
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 499
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,988
medulloblastoma 7 | 1,524
pituitary cancer 7 | 1,972
posterior fossa group B ependymoma 7 | 1,530
Colorectal Neoplasms 6 | 217
Craniofacial Abnormalities 6 | 147
Liver disease 6 | 219
Obesity 6 | 616
Rheumatoid Arthritis 6 | 1,171
Ureteral disease 6 | 23
Waldenstrons macroglobulinemia 6 | 765
adrenocortical carcinoma 6 | 1,427
astrocytoma 6 | 1,493
ulcerative colitis 6 | 2,087
Colorectal Cancer 5 | 62
Duchenne muscular dystrophy 5 | 602
Glaucoma 5 | 135
Hypertension 5 | 293
Hypertensive disease 5 | 193
Inflammatory bowel disease 5 | 142
Liver Cirrhosis 5 | 101
Osteoporosis 5 | 259
Prostatic Neoplasms 5 | 471
breast carcinoma 5 | 1,614
cutaneous lupus erythematosus 5 | 1,056
gastric carcinoma 5 | 832
hepatocellular carcinoma 5 | 550
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
spina bifida 5 | 1,064
Adenoma 4 | 165
Amyotrophic Lateral Sclerosis 4 | 432
Aortic aneurysm 4 | 34
Atopic dermatitis 4 | 944
Cleft palate 4 | 125
Familial thoracic aortic aneurysm and aortic dissection 4 | 13
Heart disease 4 | 279
Liver Cirrhosis, Experimental 4 | 108
Loeys-Dietz syndrome 4 | 23
Lung Neoplasms 4 | 171
Multiple Sclerosis 4 | 498
Neoplasm Metastasis 4 | 138
Osteoarthritis 4 | 96
Pneumonia 4 | 133
Vascular disease 4 | 281
active Crohn's disease 4 | 918
acute myeloid leukemia 4 | 785
mucosa-associated lymphoid tissue lymphoma 4 | 480
ovarian neoplasm 4 | 97
posterior fossa group A ependymoma 4 | 1,511
tuberculosis and treatment for 6 months 4 | 686
Alzheimer's disease 3 | 644
Becker muscular dystrophy 3 | 187
Down syndrome 3 | 548
Proliferative vitreoretinopathy 3 | 17
aldosterone-producing adenoma 3 | 664
colon cancer 3 | 1,475
esophageal adenocarcinoma 3 | 737
sonic hedgehog group medulloblastoma 3 | 1,482

Tissue

Blood and immune system 53 | 17,995
Cardiovascular System 53 | 17,958
Digestive Tract 53 | 18,473
Endocrine System 53 | 18,512
Female tissues 53 | 18,647
Liver and Pancreas 53 | 18,136
Male tissues 53 | 17,969
Nervous System 53 | 18,561
Respiratory system 53 | 17,484
Skin and soft tissues 53 | 18,115
Urinary Tract 53 | 18,444

Target Family

Non-IDG 26 | 11,969
Enzyme 15 | 4,146
Kinase 7 | 634
Transcription Factor 5 | 1,400

PathwayCommons: pid Pathway

TGF-beta receptor signaling 53 | 53
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase SMURF1 SMURF1 Tbio Enzyme -1.90072 75.1 274
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.12904 1149.7 572
Serine-threonine kinase receptor-associated protein STRAP Tbio Enzyme -1.30190 20.6 123
Transforming growth factor-beta receptor-associated protein 1 TGFBRAP1 Tbio Non-IDG -0.98693 8.90 158
Disabled homolog 2 DAB2 Tbio Non-IDG -2.24622 174.6 226
Eukaryotic translation initiation factor 2A EIF2A Tbio Non-IDG -0.57210 3.87 227
TGF-beta receptor type-2 TGFBR2 Tchem Kinase -2.81736 519.3 441
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit PPP1CA Tchem Enzyme -2.15861 136.6 346
E3 ubiquitin-protein ligase NEDD4-like NEDD4L Tbio Enzyme -2.50001 312.7 133
Protein PML PML Tbio Non-IDG -2.60528 345.2 417