Development Level

Tbio 9 | 10,625
Tchem 8 | 1,890
Tclin 6 | 602

IMPC Phenotype

preweaning lethality, complete... 2 | 633
abnormal behavior 1 | 226
abnormal femur morphology 1 | 14
abnormal limb bud morphology 1 | 15
abnormal limb morphology 1 | 7
abnormal tail morphology 1 | 17
cyanosis 1 | 6
decreased basophil cell number 1 | 11
decreased bone mineral content 1 | 157
decreased lean body mass 1 | 195
decreased leukocyte cell numbe... 1 | 54
decreased lumbar vertebrae num... 1 | 62
edema 1 | 11
hemorrhage 1 | 12
hydrops fetalis 1 | 22
increased sacral vertebrae num... 1 | 62
respiratory system phenotype 1 | 2

Disease

Cancer 12 | 2,346
ovarian cancer 11 | 8,491
glioblastoma 10 | 5,572
medulloblastoma, large-cell 10 | 6,234
osteosarcoma 10 | 7,933
diabetes mellitus 9 | 1,663
pilocytic astrocytoma 9 | 3,086
malignant mesothelioma 8 | 3,163
non-small cell lung cancer 8 | 2,798
pituitary cancer 8 | 1,972
atypical teratoid / rhabdoid tumor 7 | 4,369
lung cancer 7 | 4,473
oligodendroglioma 7 | 2,849
psoriasis 7 | 6,685
Alzheimer's disease 6 | 644
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
invasive ductal carcinoma 6 | 2,950
pediatric high grade glioma 6 | 2,712
ulcerative colitis 6 | 2,087
Bladder Neoplasm 5 | 109
Breast cancer 5 | 3,098
Obesity 5 | 616
breast carcinoma 5 | 1,614
esophageal adenocarcinoma 5 | 737
interstitial cystitis 5 | 2,299
Down syndrome 4 | 548
Hidradenitis suppurativa 4 | 12
Mammary Neoplasms 4 | 410
Stomach Neoplasms 4 | 282
colon cancer 4 | 1,475
ductal carcinoma in situ 4 | 1,745
lung carcinoma 4 | 2,844
pancreatic cancer 4 | 2,300
subependymal giant cell astrocytoma 4 | 2,287
Acne 3 | 20
Animal Mammary Neoplasms 3 | 135
Arthritis 3 | 248
Bipolar Disorder 3 | 266
Carcinoma 3 | 2,147
Cholangiocarcinoma 3 | 32
Cholestasis 3 | 93
Cleft palate 3 | 125
Colorectal Neoplasms 3 | 217
Craniosynostosis 3 | 47
Diarrhea 3 | 155
Endometriosis 3 | 535
Eye disease 3 | 55
Gout 3 | 93
Hamman-Rich syndrome 3 | 35
Hidradenitis suppurativa, familial 3 | 3
Intellectual disability 3 | 573
Kidney disease 3 | 397
Liver carcinoma 3 | 217
Mammary Neoplasms, Experimental 3 | 149
Metabolic syndrome X 3 | 155
Osteoporosis 3 | 259
Prostatic Neoplasms 3 | 471
Urinary bladder cancer 3 | 34
adrenocortical carcinoma 3 | 1,427
adult high grade glioma 3 | 2,148
astrocytic glioma 3 | 2,241
astrocytoma 3 | 1,493
cutaneous lupus erythematosus 3 | 1,056
ependymoma 3 | 2,514
group 3 medulloblastoma 3 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
juvenile dermatomyositis 3 | 1,189
lung adenocarcinoma 3 | 2,714
medulloblastoma 3 | 1,524
non primary Sjogren syndrome sicca 3 | 840
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
sonic hedgehog group medulloblastoma 3 | 1,482
spina bifida 3 | 1,064
tuberculosis 3 | 1,563
Acrocephalosyndactylia 2 | 15
Adenoma 2 | 165
Allergic hypersensitivity disease 2 | 123
Atherosclerosis 2 | 275
Cerebrovascular disease 2 | 231
Cleft Lip 2 | 91
Colonic Neoplasms 2 | 126
Endometrial Neoplasms 2 | 50
Epilepsy 2 | 346
Giant Cell Glioblastoma 2 | 12
Heart disease 2 | 279
Hypersensitivity reaction type II disease 2 | 235
Hypertension 2 | 293
Infertility 2 | 163
Inflammatory bowel disease 2 | 142
Lung disease 2 | 136
Multiple Sclerosis 2 | 498
Pain agnosia 2 | 99
Prostate cancer 2 | 172
Proteinuria 2 | 63
Uterine Cervical Neoplasm 2 | 21
atypical teratoid/rhabdoid tumor 2 | 1,095
cystic fibrosis 2 | 1,670
gliosarcoma 2 | 19
non-small cell lung carcinoma 2 | 413
tuberculosis and treatment for 6 months 2 | 686

Tissue

Digestive Tract 23 | 18,472
Endocrine System 23 | 18,511
Female tissues 23 | 18,646
Nervous System 23 | 18,560
Skin and soft tissues 23 | 18,114
Urinary Tract 23 | 18,443
Blood and immune system 22 | 17,994
Cardiovascular System 22 | 17,957
Liver and Pancreas 22 | 18,135
Respiratory system 21 | 17,483
Male tissues 20 | 17,968

Target Family

Non-IDG 11 | 11,969
Kinase 7 | 634
Enzyme 4 | 4,146
GPCR 1 | 408

PathwayCommons: pid Pathway

Syndecan-3-mediated signaling ... 23 | 23
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84368 678.2 177
Nicastrin NCSTN Tbio Non-IDG -2.13111 143.4 321
Fibroblast growth factor receptor 4 FGFR4 Tclin Kinase -2.40965 255.8 442
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -3.98540 8801.0 1257
Neurocan core protein NCAN Tbio Non-IDG -2.18026 145.4 111
Interleukin-8 CXCL8 Tchem Non-IDG -3.98343 9346.7 993
Epidermal growth factor receptor EGFR Tclin Kinase -3.98983 9318.1 4989
Presenilin-1 PSEN1 Tchem Enzyme -3.51146 3533.8 593
Syndecan-3 SDC3 Tbio Non-IDG -1.83869 73.3 153
Agouti-related protein AGRP Tbio Non-IDG -2.65686 471.4 168