Development Level

Tchem 35 | 1,890
Tbio 19 | 10,625
Tclin 13 | 602

IMPC Term

preweaning lethality, complete... 2 | 633
preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal coping response 1 | 12
abnormal femur morphology 1 | 14
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal joint morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 100
abnormal snout morphology 1 | 18
abnormal startle reflex 1 | 14
cataract 1 | 26
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating iron lev... 1 | 25
decreased hematocrit 1 | 25
decreased mean corpuscular vol... 1 | 50
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
hydrops fetalis 1 | 22
increased bone mineral density 1 | 52
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
male infertility 1 | 62
short tibia 1 | 82

Disease

Cancer 48 | 2,346
ovarian cancer 48 | 8,484
osteosarcoma 45 | 7,933
glioblastoma 41 | 5,572
psoriasis 35 | 6,685
medulloblastoma, large-cell 34 | 6,234
atypical teratoid / rhabdoid tumor 29 | 4,369
lung cancer 29 | 4,466
Breast cancer 22 | 3,094
pilocytic astrocytoma 21 | 3,086
Carcinoma 20 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,289
oligodendroglioma 18 | 2,849
pancreatic cancer 18 | 2,300
diabetes mellitus 17 | 1,663
pediatric high grade glioma 17 | 2,712
invasive ductal carcinoma 16 | 2,950
lung adenocarcinoma 16 | 2,713
primitive neuroectodermal tumor 16 | 3,031
subependymal giant cell astrocytoma 16 | 2,287
ependymoma 15 | 2,514
non-small cell lung cancer 15 | 2,798
ulcerative colitis 15 | 2,087
astrocytoma 14 | 1,493
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
Pick disease 13 | 1,893
adult high grade glioma 13 | 2,148
interstitial cystitis 13 | 2,299
juvenile dermatomyositis 13 | 1,189
posterior fossa group A ependymoma 13 | 1,511
Alzheimer's disease 12 | 644
Rheumatoid Arthritis 12 | 1,160
group 4 medulloblastoma 12 | 1,875
lung carcinoma 12 | 2,844
medulloblastoma 12 | 1,524
pancreatic carcinoma 12 | 567
tuberculosis 12 | 1,557
Mammary Neoplasms 11 | 410
Multiple myeloma 11 | 1,327
Vascular disease 11 | 281
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,956
Heart disease 10 | 279
Prostatic Neoplasms 10 | 471
astrocytic glioma 10 | 2,241
dermatomyositis 10 | 933
Hypertension 9 | 287
Waldenstrons macroglobulinemia 9 | 765
group 3 medulloblastoma 9 | 2,254
malignant mesothelioma 9 | 3,162
primary pancreatic ductal adenocarcinoma 9 | 1,271
Colorectal Neoplasms 8 | 217
Kidney disease 8 | 396
Lung Neoplasms 8 | 171
Stomach Neoplasms 8 | 282
acute quadriplegic myopathy 8 | 1,157
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
Arthritis 7 | 248
Cardiomyopathy 7 | 110
Lung disease 7 | 132
Neoplasm Metastasis 7 | 138
Noonan Syndrome 7 | 33
Schizophrenia 7 | 501
colon cancer 7 | 1,475
non-small cell lung carcinoma 7 | 413
pituitary cancer 7 | 1,972
Atherosclerosis 6 | 275
Cardiomegaly 6 | 66
Cardiomyopathies 6 | 90
Cerebrovascular disease 6 | 231
Diabetic Retinopathy 6 | 53
Intellectual disability 6 | 573
Melanoma 6 | 261
Neoplasm Invasiveness 6 | 127
Obesity 6 | 616
Proteinuria 6 | 63
Renal Cell Carcinoma 6 | 199
Squamous cell carcinoma 6 | 94
breast carcinoma 6 | 1,614
cystic fibrosis 6 | 1,665
mucosa-associated lymphoid tissue lymphoma 6 | 480
nasopharyngeal carcinoma 6 | 1,056
ovarian neoplasm 6 | 97
Adenoma 5 | 165
Asthma 5 | 349
Carcinoma of thyroid 5 | 17
Colon Carcinoma 5 | 25
Crohn's disease 5 | 304
Diabetes Mellitus, Experimental 5 | 106
Hemangiosarcoma 5 | 18
Liver Cirrhosis 5 | 101
Liver cell carcinoma 5 | 15
Myocardial Ischemia 5 | 169
Osteoporosis 5 | 257
atypical teratoid/rhabdoid tumor 5 | 1,095
ductal carcinoma in situ 5 | 1,745
gastric cancer 5 | 430
primary Sjogren syndrome 5 | 789
progressive supranuclear palsy 5 | 674
spina bifida 5 | 1,064
tuberculosis and treatment for 6 months 5 | 686

Tissue

Blood and immune system 67 | 17,995
Cardiovascular System 67 | 17,958
Digestive Tract 67 | 18,473
Endocrine System 67 | 18,512
Female tissues 67 | 18,647
Liver and Pancreas 67 | 18,136
Male tissues 67 | 17,969
Nervous System 67 | 18,561
Respiratory system 67 | 17,484
Skin and soft tissues 67 | 18,115
Urinary Tract 67 | 18,444

Target Family

Kinase 29 | 634
Non-IDG 22 | 11,971
Enzyme 14 | 4,146
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

PathwayCommons: pid Pathway

Signaling events mediated by V... 67 | 67
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Receptor-type tyrosine-protein phosphatase eta PTPRJ Tbio Enzyme -1.94494 110.6 235
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424
Catenin alpha-1 CTNNA1 Tbio Non-IDG -1.91334 73.6 399
Transforming protein RhoA RHOA Tbio Enzyme -3.48838 3096.5 467
Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Tchem Enzyme -3.06784 1308.8 971
3-phosphoinositide-dependent protein kinase 1 PDPK1 Tchem Kinase -2.24871 191.5 579
Dual specificity mitogen-activated protein kinase kinase 2 MAP2K2 Tclin Kinase -1.78634 57.0 688
Dynamin-2 DNM2 Tchem Non-IDG -3.22299 1426.1 125
Calcium/calmodulin-dependent protein kinase kinase 2 CAMKK2 Tchem Kinase -2.05942 116.8 211