Development Level

Tbio 16 | 10,625
Tchem 9 | 1,890
Tclin 2 | 602

IMPC Term

abnormal behavioral response t... 1 | 52
abnormal epididymis morphology 1 | 31
abnormal gait 1 | 51
abnormal heart morphology 1 | 51
abnormal iris morphology 1 | 12
abnormal maxilla morphology 1 | 16
abnormal placement of pupils 1 | 4
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal sleep behavior 1 | 63
abnormal snout morphology 1 | 18
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
decreased Ly6C low monocyte nu... 1 | 23
decreased bone mineral density 1 | 126
decreased circulating insulin ... 1 | 75
decreased circulating total pr... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased prepulse inhibition 1 | 52
decreased rib number 1 | 59
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged spleen 1 | 26
hyperactivity 1 | 108
hypoactivity 1 | 89
increased bone mineral density 1 | 52
increased circulating choleste... 1 | 53
increased effector memory CD4-... 1 | 15
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased plasma cell number 1 | 5
irregularly shaped pupil 1 | 7
narrow eye opening 1 | 15
preweaning lethality, incomple... 1 | 260
prolonged QRS complex duration 1 | 2
small testis 1 | 37
thrombocytopenia 1 | 46

Disease

Cancer 19 | 2,346
osteosarcoma 15 | 7,933
psoriasis 15 | 6,685
ovarian cancer 14 | 8,484
medulloblastoma, large-cell 13 | 6,234
lung cancer 11 | 4,466
diabetes mellitus 10 | 1,663
Breast cancer 7 | 3,094
Obesity 7 | 616
atypical teratoid / rhabdoid tumor 7 | 4,369
ductal carcinoma in situ 7 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
invasive ductal carcinoma 7 | 2,950
lung adenocarcinoma 7 | 2,713
malignant mesothelioma 7 | 3,162
acute quadriplegic myopathy 6 | 1,157
adrenocortical carcinoma 6 | 1,427
glioblastoma 6 | 5,572
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,988
pancreatic cancer 6 | 2,300
Adenoid Cystic Carcinoma 5 | 99
Amyotrophic Lateral Sclerosis 5 | 431
Bladder Neoplasm 5 | 109
Diabetes Mellitus, Experimental 5 | 106
Mammary Neoplasms 5 | 410
Metabolic syndrome X 5 | 155
Prostatic Neoplasms 5 | 471
Vascular disease 5 | 281
adult high grade glioma 5 | 2,148
astrocytic glioma 5 | 2,241
astrocytoma 5 | 1,493
group 3 medulloblastoma 5 | 2,254
hepatocellular carcinoma 5 | 532
non-small cell lung cancer 5 | 2,798
oligodendroglioma 5 | 2,849
pituitary cancer 5 | 1,972
subependymal giant cell astrocytoma 5 | 2,287
Carcinoma, Transitional Cell 4 | 31
Endometriosis 4 | 535
Huntington's disease 4 | 72
Pick disease 4 | 1,893
Squamous cell carcinoma of esophagus 4 | 82
colon cancer 4 | 1,475
ependymoma 4 | 2,514
nasopharyngeal carcinoma 4 | 1,056
non-small cell lung carcinoma 4 | 413
pancreatic carcinoma 4 | 567
pilocytic astrocytoma 4 | 3,086
sonic hedgehog group medulloblastoma 4 | 1,482
spina bifida 4 | 1,064
tuberculosis 4 | 1,557
ulcerative colitis 4 | 2,087
Acute kidney injury 3 | 65
Colonic Neoplasms 3 | 126
Fatty liver disease 3 | 84
HIV Infections 3 | 100
Hyperglycemia 3 | 120
Intellectual disability 3 | 573
Leukemia, Myelocytic, Acute 3 | 113
Lymphoid leukemia 3 | 69
Multiple myeloma 3 | 1,327
Neurodegenerative disease 3 | 383
Parkinson's disease 3 | 364
Rheumatoid Arthritis 3 | 1,160
Small cell carcinoma of lung 3 | 45
breast carcinoma 3 | 1,614
cutaneous lupus erythematosus 3 | 1,056
dermatomyositis 3 | 933
gastric cancer 3 | 430
gastric carcinoma 3 | 832
glioblastoma multiforme 3 | 347
group 4 medulloblastoma 3 | 1,875
inflammatory breast cancer 3 | 404
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
juvenile dermatomyositis 3 | 1,189
posterior fossa group A ependymoma 3 | 1,511
Adenoma 2 | 165
Alzheimer's disease 2 | 644
Atopic dermatitis 2 | 944
Colorectal Neoplasms 2 | 217
Diabetes Mellitus, Non-Insulin-Dependent 2 | 157
Down syndrome 2 | 548
Duchenne muscular dystrophy 2 | 602
Ganglioglioma 2 | 16
Hepatitis B 2 | 103
Kidney disease 2 | 396
Male infertility 2 | 170
Multiple Sclerosis 2 | 498
Peripheral Neuropathy 2 | 303
Polycystic Ovary Syndrome 2 | 332
Rubinstein-Taybi syndrome 2 | 11
Schizophrenia 2 | 501
Stomach Neoplasms 2 | 282
Waldenstrons macroglobulinemia 2 | 765
active ulcerative colitis 2 | 477
acute myeloid leukemia 2 | 780
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
fibroadenoma 2 | 557
pediatric high grade glioma 2 | 2,712
primary pancreatic ductal adenocarcinoma 2 | 1,271

Tissue

Blood and immune system 27 | 17,995
Cardiovascular System 27 | 17,958
Digestive Tract 27 | 18,473
Endocrine System 27 | 18,512
Female tissues 27 | 18,647
Liver and Pancreas 27 | 18,136
Male tissues 27 | 17,969
Nervous System 27 | 18,561
Skin and soft tissues 27 | 18,115
Urinary Tract 27 | 18,444
Respiratory system 26 | 17,484

Target Family

Non-IDG 9 | 11,971
Epigenetic 8 | 242
Transcription Factor 7 | 1,400
Enzyme 3 | 4,146

PathwayCommons: pid Pathway

Signaling events mediated by H... 27 | 27
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tubulin beta-2A chain TUBB2A Tclin Non-IDG -1.58651 36.1 215
Cyclin-dependent kinase inhibitor 1 CDKN1A Tbio Enzyme -3.43357 2997.4 1177
Histone H4 HIST2H4A Tbio Non-IDG -2.57230 138.5 770
Histone H3.3 H3F3B Tbio Non-IDG -2.06154 100.6 415
Histone acetyltransferase p300 EP300 Tchem Epigenetic -3.75838 5701.8 723
Forkhead box protein O4 FOXO4 Tbio Transcription Factor -2.37435 252.7 673
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -2.96006 1000.8 1343
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.85040 758.9 787
Myocyte-specific enhancer factor 2D MEF2D Tbio Transcription Factor -1.89292 79.1 279
Myoblast determination protein 1 MYOD1 Tbio Transcription Factor -3.13423 1281.5 563