Development Level

Tbio 6 | 10,625
Tchem 1 | 1,890
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 2 | 633
abnormal behavior 1 | 226
abnormal spleen morphology 1 | 36
decreased bone mineral content 1 | 157
decreased fasted circulating g... 1 | 49
decreased respiratory quotient 1 | 12
decreased startle reflex 1 | 48
hyperactivity 1 | 108
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased circulating creatini... 1 | 29

Disease

osteosarcoma 6 | 7,933
glioblastoma 5 | 5,572
medulloblastoma, large-cell 5 | 6,234
ovarian cancer 4 | 8,484
pilocytic astrocytoma 4 | 3,086
subependymal giant cell astrocytoma 4 | 2,287
astrocytoma 3 | 1,493
atypical teratoid / rhabdoid tumor 3 | 4,369
colon cancer 3 | 1,475
group 3 medulloblastoma 3 | 2,254
lung carcinoma 3 | 2,844
oligodendroglioma 3 | 2,849
pediatric high grade glioma 3 | 2,712
posterior fossa group A ependymoma 3 | 1,511
primitive neuroectodermal tumor 3 | 3,031
psoriasis 3 | 6,685
Amnesia 2 | 17
Breast cancer 2 | 3,094
Crohn's disease 2 | 304
Multiple myeloma 2 | 1,327
Rheumatoid Arthritis 2 | 1,160
Substance Withdrawal Syndrome 2 | 52
Waldenstrons macroglobulinemia 2 | 765
acute quadriplegic myopathy 2 | 1,157
adult high grade glioma 2 | 2,148
astrocytic glioma 2 | 2,241
atypical teratoid/rhabdoid tumor 2 | 1,095
breast carcinoma 2 | 1,614
diabetes mellitus 2 | 1,663
interstitial cystitis 2 | 2,299
pancreatic cancer 2 | 2,300
primary pancreatic ductal adenocarcinoma 2 | 1,271
ulcerative colitis 2 | 2,087
Angioimmunoblastic Lymphadenopathy 1 | 4
Animal Mammary Neoplasms 1 | 136
Asthma 1 | 349
Atherosclerosis 1 | 275
Atrioventricular block 1 | 21
Auriculo-condylar syndrome 1 | 3
Autosomal recessive nonsyndromic deafness 1 | 4
Bladder Neoplasm 1 | 109
Bradycardia 1 | 24
Cancer 1 | 2,346
Cerebrovascular disease 1 | 231
Cholera 1 | 33
Clostridium difficile colitis 1 | 12
Diabetes Mellitus, Experimental 1 | 106
Duchenne muscular dystrophy 1 | 602
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 17 1 | 1
Early infantile epileptic encephalopathy with suppression bursts 1 | 18
Epilepsy 1 | 346
Familial ventricular tachycardia 1 | 1
Granulosa cell tumor of the ovary 1 | 1
Heart disease 1 | 279
Hypertension 1 | 287
IGA Glomerulonephritis 1 | 454
Impotence 1 | 45
Kidney disease 1 | 396
Lung disease 1 | 132
Lymphoma, T-Cell, Cutaneous 1 | 21
Lymphopenia 1 | 35
Major Depressive Disorder 1 | 106
Mammary Neoplasms 1 | 410
Mammary Neoplasms, Experimental 1 | 150
Mental depression 1 | 58
Multiple Sclerosis 1 | 498
Myocardial Ischemia 1 | 169
Neoplasm Invasiveness 1 | 127
Neoplasm Recurrence, Local 1 | 23
Neurodegenerative disease 1 | 383
Ocular albinism 1 | 29
Organ system cancer 1 | 15
Peripheral T-cell lymphoma 1 | 24
Pick disease 1 | 1,893
Pituitary-dependent Cushing's disease 1 | 8
Polycystic Ovary Syndrome 1 | 332
Proteinuria 1 | 63
Pseudosarcomatous fibromatosis 1 | 10
Relapsing remitting multiple sclerosis 1 | 14
Stomach Neoplasms 1 | 282
T-Cell Lymphoma 1 | 11
acute myeloid leukemia 1 | 780
cutaneous lupus erythematosus 1 | 1,056
dermatomyositis 1 | 933
ductal carcinoma in situ 1 | 1,745
ependymoma 1 | 2,514
facioscapulohumeral dystrophy 1 | 286
fibroadenoma 1 | 557
invasive ductal carcinoma 1 | 2,950
juvenile dermatomyositis 1 | 1,189
lung adenocarcinoma 1 | 2,713
lung cancer 1 | 4,466
mucosa-associated lymphoid tissue lymphoma 1 | 480
non-small cell lung cancer 1 | 2,798
pancreatic carcinoma 1 | 567
posterior fossa group B ependymoma 1 | 1,530
sonic hedgehog group medulloblastoma 1 | 1,482
tuberculosis 1 | 1,557
type I diabetes mellitus 1 | 22

Tissue

Blood and immune system 8 | 17,995
Cardiovascular System 8 | 17,958
Digestive Tract 8 | 18,473
Endocrine System 8 | 18,512
Female tissues 8 | 18,647
Liver and Pancreas 8 | 18,136
Male tissues 8 | 17,969
Nervous System 8 | 18,561
Respiratory system 8 | 17,484
Skin and soft tissues 8 | 18,115
Urinary Tract 8 | 18,444

Target Family

Non-IDG 6 | 11,971
Enzyme 1 | 4,146
GPCR 1 | 406

PathwayCommons: pid Pathway

S1P5 pathway 8 | 8
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transforming protein RhoA RHOA Tbio Enzyme -3.48838 3096.5 467
Guanine nucleotide-binding protein G(i) subunit alpha-2 GNAI2 Tbio Non-IDG -1.23038 16.6 188
Guanine nucleotide-binding protein G(i) subunit alpha-1 GNAI1 Tchem Non-IDG -0.58837 3.11 173
Sphingosine 1-phosphate receptor 5 S1PR5 Tclin GPCR -1.63868 42.6 227
Guanine nucleotide-binding protein subunit alpha-12 GNA12 Tbio Non-IDG -0.94670 8.08 143
Guanine nucleotide-binding protein G(z) subunit alpha GNAZ Tbio Non-IDG -1.57258 38.6 220
Guanine nucleotide-binding protein G(o) subunit alpha GNAO1 Tbio Non-IDG -2.22083 154.8 177
Guanine nucleotide-binding protein G(k) subunit alpha GNAI3 Tbio Non-IDG -1.39635 23.8 117