Development Level

Tbio 15 | 10,625
Tchem 11 | 1,890

IMPC Term

decreased bone mineral content 3 | 157
abnormal behavior 2 | 226
increased blood urea nitrogen ... 2 | 44
preweaning lethality, complete... 2 | 633
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal spleen morphology 1 | 36
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 24
decreased circulating phosphat... 1 | 15
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
decreased respiratory quotient 1 | 12
decreased startle reflex 1 | 48
hyperactivity 1 | 108
impaired righting response 1 | 19
increased circulating calcium ... 1 | 32
increased circulating creatini... 1 | 29
increased fasted circulating g... 1 | 68
vertebral fusion 1 | 23

Disease

medulloblastoma, large-cell 17 | 6,234
osteosarcoma 17 | 7,933
ovarian cancer 17 | 8,484
Cancer 15 | 2,346
psoriasis 15 | 6,685
glioblastoma 14 | 5,572
atypical teratoid / rhabdoid tumor 13 | 4,369
lung cancer 10 | 4,466
diabetes mellitus 9 | 1,663
lung carcinoma 9 | 2,844
Breast cancer 8 | 3,094
colon cancer 8 | 1,475
group 4 medulloblastoma 8 | 1,875
primitive neuroectodermal tumor 8 | 3,031
Alzheimer's disease 7 | 644
astrocytoma 7 | 1,493
breast carcinoma 7 | 1,614
juvenile dermatomyositis 7 | 1,189
non-small cell lung cancer 7 | 2,798
oligodendroglioma 7 | 2,849
pancreatic cancer 7 | 2,300
subependymal giant cell astrocytoma 7 | 2,287
ulcerative colitis 7 | 2,087
Arthritis 6 | 248
Lung Neoplasms 6 | 171
Mammary Neoplasms 6 | 410
Parkinson's disease 6 | 364
Pick disease 6 | 1,893
Rheumatoid Arthritis 6 | 1,160
Stomach Neoplasms 6 | 282
Vascular disease 6 | 281
Waldenstrons macroglobulinemia 6 | 765
adult high grade glioma 6 | 2,148
invasive ductal carcinoma 6 | 2,950
pediatric high grade glioma 6 | 2,712
pilocytic astrocytoma 6 | 3,086
Kidney disease 5 | 396
Liver carcinoma 5 | 217
Lung disease 5 | 132
Obesity 5 | 616
Substance Withdrawal Syndrome 5 | 52
acute quadriplegic myopathy 5 | 1,157
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,289
lung adenocarcinoma 5 | 2,713
posterior fossa group A ependymoma 5 | 1,511
tuberculosis 5 | 1,557
Carcinoma 4 | 2,147
Eye disease 4 | 55
Heart disease 4 | 279
Neoplastic Cell Transformation 4 | 81
Toxic encephalopathy 4 | 131
acute myeloid leukemia 4 | 780
astrocytic glioma 4 | 2,241
ependymoma 4 | 2,514
interstitial cystitis 4 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
malignant mesothelioma 4 | 3,162
medulloblastoma 4 | 1,524
pituitary cancer 4 | 1,972
Asthma 3 | 349
Brain Ischemia 3 | 87
Brain disease 3 | 83
Cardiomyopathies 3 | 90
Cholera 3 | 33
Cocaine-Related Disorders 3 | 88
Crohn's disease 3 | 304
Fibrous dysplasia 3 | 15
Gastrointestinal system disease 3 | 50
Hyperglycemia 3 | 120
Hypertension 3 | 287
IGA Glomerulonephritis 3 | 454
Juvenile arthritis 3 | 124
Melanoma 3 | 261
Multiple Sclerosis 3 | 498
Multiple myeloma 3 | 1,327
Neoplasm Invasiveness 3 | 127
Neoplasm Metastasis 3 | 138
Prostatic Neoplasms 3 | 471
Renal Cell Carcinoma 3 | 199
Reperfusion Injury 3 | 84
Squamous cell carcinoma 3 | 94
active ulcerative colitis 3 | 477
atypical teratoid/rhabdoid tumor 3 | 1,095
fibroadenoma 3 | 557
gastric cancer 3 | 430
group 3 medulloblastoma 3 | 2,254
nephrosclerosis 3 | 329
ovarian neoplasm 3 | 97
pancreatic carcinoma 3 | 567
posterior fossa group B ependymoma 3 | 1,530
urothelial carcinoma 3 | 318
Myocardial Ischemia 2 | 169
adrenocortical carcinoma 2 | 1,427
chronic lymphosyte leukemia 2 | 232
cystic fibrosis 2 | 1,665
hepatocellular carcinoma 2 | 532
inflammatory breast cancer 2 | 404
pterygium 2 | 74

Tissue

Blood and immune system 26 | 17,995
Cardiovascular System 26 | 17,958
Digestive Tract 26 | 18,473
Endocrine System 26 | 18,512
Female tissues 26 | 18,647
Liver and Pancreas 26 | 18,136
Male tissues 26 | 17,969
Nervous System 26 | 18,561
Respiratory system 26 | 17,484
Skin and soft tissues 26 | 18,115
Urinary Tract 26 | 18,444

Target Family

Non-IDG 13 | 11,971
Kinase 7 | 634
Transcription Factor 3 | 1,400
Enzyme 2 | 4,146
GPCR 1 | 406

PathwayCommons: pid Pathway

S1P2 pathway 26 | 26
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Transforming protein RhoA RHOA Tbio Enzyme -3.48838 3096.5 467
Guanine nucleotide-binding protein G(i) subunit alpha-2 GNAI2 Tbio Non-IDG -1.23038 16.6 188
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.60410 3186.8 1232
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.80612 564.2 147
Guanine nucleotide-binding protein G(q) subunit alpha GNAQ Tbio Non-IDG -2.70830 492.8 177
Guanine nucleotide-binding protein subunit alpha-15 GNA15 Tbio Non-IDG -2.74307 475.0 155
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.12872 1138.1 1044
Guanine nucleotide-binding protein subunit alpha-14 GNA14 Tbio Non-IDG -0.62956 4.34 120