Development Level

Tbio 55 | 10,625
Tchem 19 | 1,890
Tclin 8 | 602

IMPC Term

abnormal eye morphology 2 | 38
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
decreased circulating total pr... 2 | 41
decreased total body fat amoun... 2 | 186
abnormal behavior 1 | 226
abnormal behavioral response t... 1 | 52
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 51
abnormal maxilla morphology 1 | 16
abnormal placement of pupils 1 | 4
abnormal sleep behavior 1 | 63
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
decreased Ly6C low monocyte nu... 1 | 23
decreased bone mineral density 1 | 126
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased prepulse inhibition 1 | 52
decreased startle reflex 1 | 48
dilated heart left ventricle 1 | 10
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged spleen 1 | 26
female infertility 1 | 34
hydrops fetalis 1 | 22
hypoactivity 1 | 89
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased hematocrit 1 | 36
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased plasma cell number 1 | 5
male infertility 1 | 62
microphthalmia 1 | 15
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
prolonged QRS complex duration 1 | 2
small testis 1 | 37
thrombocytopenia 1 | 46

Disease

ovarian cancer 57 | 8,484
osteosarcoma 55 | 7,933
Cancer 54 | 2,346
psoriasis 45 | 6,685
glioblastoma 38 | 5,572
medulloblastoma, large-cell 36 | 6,234
lung cancer 29 | 4,466
atypical teratoid / rhabdoid tumor 28 | 4,369
malignant mesothelioma 25 | 3,162
astrocytoma 22 | 1,493
invasive ductal carcinoma 22 | 2,950
primitive neuroectodermal tumor 22 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
pediatric high grade glioma 20 | 2,712
pilocytic astrocytoma 20 | 3,086
ulcerative colitis 20 | 2,087
Breast cancer 19 | 3,094
subependymal giant cell astrocytoma 19 | 2,287
pituitary cancer 18 | 1,972
pancreatic cancer 17 | 2,300
Carcinoma 16 | 2,147
acute quadriplegic myopathy 16 | 1,157
diabetes mellitus 16 | 1,663
ductal carcinoma in situ 16 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,988
lung adenocarcinoma 16 | 2,713
Prostatic Neoplasms 15 | 471
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,956
posterior fossa group A ependymoma 15 | 1,511
Multiple myeloma 14 | 1,327
ependymoma 14 | 2,514
oligodendroglioma 14 | 2,849
tuberculosis 14 | 1,557
breast carcinoma 13 | 1,614
lung carcinoma 13 | 2,844
primary pancreatic ductal adenocarcinoma 13 | 1,271
sonic hedgehog group medulloblastoma 13 | 1,482
Obesity 12 | 616
colon cancer 12 | 1,475
group 4 medulloblastoma 12 | 1,875
non-small cell lung cancer 12 | 2,798
Kidney disease 11 | 396
Mammary Neoplasms 11 | 410
Rheumatoid Arthritis 11 | 1,160
Waldenstrons macroglobulinemia 11 | 765
group 3 medulloblastoma 11 | 2,254
Vascular disease 10 | 281
dermatomyositis 10 | 933
juvenile dermatomyositis 10 | 1,189
Asthma 9 | 349
Endometriosis 9 | 535
Pick disease 9 | 1,893
acute myeloid leukemia 9 | 780
adult high grade glioma 9 | 2,148
cystic fibrosis 9 | 1,665
interstitial cystitis 9 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
Amyotrophic Lateral Sclerosis 8 | 431
Lung Neoplasms 8 | 171
Stomach Neoplasms 8 | 282
gastric carcinoma 8 | 832
medulloblastoma 8 | 1,524
Arthritis 7 | 248
Atopic dermatitis 7 | 944
Craniofacial Abnormalities 7 | 147
Heart disease 7 | 279
Hyperglycemia 7 | 120
Inflammatory bowel disease 7 | 142
Multiple Sclerosis 7 | 498
Osteoporosis 7 | 257
aldosterone-producing adenoma 7 | 664
fibroadenoma 7 | 557
inflammatory breast cancer 7 | 404
nephrosclerosis 7 | 329
Adenoma 6 | 165
Alzheimer's disease 6 | 644
Autistic Disorder 6 | 320
Bladder Neoplasm 6 | 109
Crohn's disease 6 | 304
Epilepsy 6 | 346
Hypersensitivity reaction type II disease 6 | 235
Liver carcinoma 6 | 217
Liver disease 6 | 219
Parkinson's disease 6 | 364
Pulmonary Fibrosis 6 | 66
active Crohn's disease 6 | 918
adrenocortical carcinoma 6 | 1,427
astrocytic glioma 6 | 2,241
nasopharyngeal carcinoma 6 | 1,056
primary Sjogren syndrome 6 | 789
Hypertension 5 | 287
Hypertensive disease 5 | 193
Juvenile arthritis 5 | 124
Reperfusion Injury 5 | 84
Schizophrenia 5 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
chronic lymphosyte leukemia 5 | 232
cutaneous lupus erythematosus 5 | 1,056
gastric cancer 5 | 430
non-small cell lung carcinoma 5 | 413

Tissue

Blood and immune system 82 | 17,995
Digestive Tract 82 | 18,473
Endocrine System 82 | 18,512
Liver and Pancreas 82 | 18,136
Nervous System 82 | 18,561
Urinary Tract 82 | 18,444
Cardiovascular System 81 | 17,958
Female tissues 81 | 18,647
Male tissues 81 | 17,969
Skin and soft tissues 81 | 18,115
Respiratory system 80 | 17,484

Target Family

Transcription Factor 41 | 1,400
Non-IDG 21 | 11,971
Epigenetic 7 | 242
Enzyme 5 | 4,146
Nuclear Receptor 5 | 48
Kinase 3 | 634

PathwayCommons: pid Pathway

Regulation of nuclear SMAD2/3 ... 82 | 82
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Transcription factor E2-alpha TCF3 Tbio Transcription Factor -2.76637 577.9 373
Paired amphipathic helix protein Sin3b SIN3B Tbio Non-IDG -1.25294 18.0 136
Mothers against decapentaplegic homolog 3 SMAD3 Tbio Transcription Factor -3.03840 1043.2 1391
Cyclin-dependent kinase inhibitor 1 CDKN1A Tbio Enzyme -3.43357 2997.4 1177
Laminin subunit gamma-1 LAMC1 Tchem Non-IDG -1.73437 53.6 239
Ig alpha-1 chain C region IGHA1 Tbio Non-IDG 0.00000 0
Protein max MAX Tbio Transcription Factor -2.11097 104.8 341
E3 SUMO-protein ligase PIAS3 PIAS3 Tbio Transcription Factor -1.69960 50.8 156
Estrogen receptor ESR1 Tclin Nuclear Receptor -3.97123 8119.2 2214