Development Level

Tbio 33 | 10,625
Tchem 4 | 1,890
Tclin 1 | 602
Tdark 1 | 7,003

IMPC Term

abnormal behavior 2 | 226
decreased bone mineral density 2 | 126
decreased mature B cell number 2 | 25
increased mean corpuscular hem... 2 | 93
abnormal behavioral response t... 1 | 52
abnormal digestive system phys... 1 | 1
abnormal hair growth 1 | 8
abnormal posture 1 | 5
decreased CD4-positive, CD25-p... 1 | 24
decreased CD4-positive, alpha ... 1 | 19
decreased NK T cell number 1 | 28
decreased T cell number 1 | 31
decreased bone mineral content 1 | 157
decreased circulating HDL chol... 1 | 77
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased fasted circulating g... 1 | 49
decreased leukocyte cell numbe... 1 | 54
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased total body fat amoun... 1 | 186
enlarged lymph nodes 1 | 27
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired righting response 1 | 19
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating sodium l... 1 | 71
increased effector memory CD4-... 1 | 15
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased sacral vertebrae num... 1 | 62
increased transitional stage T... 1 | 1
increased vertical activity 1 | 18
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 26 | 8,492
medulloblastoma, large-cell 23 | 6,234
osteosarcoma 23 | 7,933
glioblastoma 22 | 5,572
atypical teratoid / rhabdoid tumor 18 | 4,369
pilocytic astrocytoma 17 | 3,086
Carcinoma 16 | 2,147
oligodendroglioma 16 | 2,849
pediatric high grade glioma 16 | 2,712
primitive neuroectodermal tumor 16 | 3,031
ependymoma 14 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
psoriasis 13 | 6,685
subependymal giant cell astrocytoma 12 | 2,287
astrocytic glioma 11 | 2,241
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
invasive ductal carcinoma 11 | 2,950
lung cancer 11 | 4,473
group 3 medulloblastoma 10 | 2,254
group 4 medulloblastoma 10 | 1,875
interstitial cystitis 10 | 2,299
medulloblastoma 10 | 1,524
pituitary cancer 10 | 1,972
Breast cancer 9 | 3,099
Cancer 9 | 2,346
Pick disease 9 | 1,893
malignant mesothelioma 9 | 3,163
non-small cell lung cancer 9 | 2,798
ulcerative colitis 9 | 2,087
adult high grade glioma 7 | 2,148
ductal carcinoma in situ 7 | 1,745
lung carcinoma 7 | 2,844
pancreatic cancer 7 | 2,300
spina bifida 7 | 1,064
lung adenocarcinoma 6 | 2,714
primary Sjogren syndrome 6 | 789
aldosterone-producing adenoma 5 | 664
astrocytoma 5 | 1,493
breast carcinoma 5 | 1,614
primary pancreatic ductal adenocarcinoma 5 | 1,271
IGA Glomerulonephritis 4 | 454
Intellectual disability 4 | 573
Waldenstrons macroglobulinemia 4 | 765
colon cancer 4 | 1,475
cystic fibrosis 4 | 1,670
tuberculosis 4 | 1,563
Down syndrome 3 | 548
Polycystic Ovary Syndrome 3 | 335
Prostatic Neoplasms 3 | 471
acute quadriplegic myopathy 3 | 1,157
adrenocortical carcinoma 3 | 1,427
atypical teratoid/rhabdoid tumor 3 | 1,095
chronic lymphocytic leukemia 3 | 244
cutaneous lupus erythematosus 3 | 1,056
cystic fibrosis and chronic rhinosinusitis 3 | 213
dermatomyositis 3 | 967
esophageal adenocarcinoma 3 | 737
juvenile dermatomyositis 3 | 1,189
posterior fossa group B ependymoma 3 | 1,530
tuberculosis and treatment for 6 months 3 | 686
Adenocarcinoma Of Esophagus 2 | 14
Amyotrophic Lateral Sclerosis 2 | 432
Heart conduction disease 2 | 65
Hypertensive disease 2 | 193
Liver neoplasms 2 | 109
Melanoma 2 | 261
Multiple myeloma 2 | 1,328
Neoplasm Metastasis 2 | 138
Orofacial cleft 2 | 38
Precancerous Conditions 2 | 69
Schizophrenia 2 | 503
Schizotypal personality disorder 2 | 8
Skin cancer 2 | 37
Substance-Related Disorders 2 | 114
Vascular disease 2 | 281
acute myeloid leukemia 2 | 785
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
diabetes mellitus 2 | 1,663
gastric carcinoma 2 | 832
hepatocellular carcinoma 2 | 550
nasopharyngeal carcinoma 2 | 1,056
non-small cell lung carcinoma 2 | 413
periodontitis 2 | 269
progressive supranuclear palsy 2 | 674
tuberculosis and treatment for 3 months 2 | 327
Alcohol dependence 1 | 107
Anisometropia 1 | 16
COPD 1 | 116
Common variable immunodeficiency 1 | 98
Duane retraction syndrome 1 | 10
Heart failure 1 | 80
Hyperopia 1 | 33
Leukemia, Myelocytic, Acute 1 | 113
Liver Cirrhosis 1 | 101
Meckel's diverticulum 1 | 4
Neoplasm Invasiveness 1 | 127
Stevens-Johnson syndrome 1 | 91
Telangiectasis 1 | 20
X-linked endothelial corneal dystrophy 1 | 9

Tissue

Blood and immune system 39 | 17,995
Cardiovascular System 39 | 17,958
Digestive Tract 39 | 18,473
Endocrine System 39 | 18,512
Female tissues 39 | 18,647
Liver and Pancreas 39 | 18,136
Male tissues 39 | 17,969
Nervous System 39 | 18,561
Respiratory system 39 | 17,484
Skin and soft tissues 39 | 18,115
Urinary Tract 39 | 18,444

Target Family

Non-IDG 29 | 11,969
Enzyme 8 | 4,146
Kinase 2 | 634

PathwayCommons: pid Pathway

Regulation of RAC1 activity 39 | 39
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rho GTPase-activating protein 9 ARHGAP9 Tbio Enzyme -1.72520 53.3 32
Rho GTPase-activating protein 17 ARHGAP17 Tbio Enzyme -1.80007 60.0 111
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.78476 58.3 173
Beta-chimaerin CHN2 Tbio Non-IDG -1.77437 56.5 133
Rap1 GTPase-GDP dissociation stimulator 1 RAP1GDS1 Tbio Enzyme -1.28276 18.2 108
Rho guanine nucleotide exchange factor 25 ARHGEF25 Tbio Non-IDG -1.42716 30.4 46
Guanine nucleotide exchange factor VAV3 VAV3 Tbio Non-IDG -1.78968 69.0 206
Active breakpoint cluster region-related protein ABR Tbio Non-IDG -2.30011 195.0 24
Epidermal growth factor receptor kinase substrate 8 EPS8 Tbio Enzyme -1.81490 77.2 248
T-lymphoma invasion and metastasis-inducing protein 2 TIAM2 Tbio Non-IDG -1.14591 14.7 143