Development Level

Tchem 27 | 1,890
Tbio 17 | 10,625
Tclin 9 | 602
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 3 | 633
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal snout morphology 2 | 18
embryonic lethality prior to t... 2 | 187
increased grip strength 2 | 83
increased or absent threshold ... 2 | 128
male infertility 2 | 62
abnormal bone mineralization 1 | 55
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal iris morphology 1 | 12
abnormal maxilla morphology 1 | 16
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal optic disc morphology 1 | 10
abnormal ovary morphology 1 | 3
abnormal placement of pupils 1 | 4
abnormal spinal cord morpholog... 1 | 8
abnormal tooth morphology 1 | 24
absent epididymis 1 | 2
absent seminal vesicle 1 | 2
absent vibrissae 1 | 14
decreased Ly6C low monocyte nu... 1 | 23
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating choleste... 1 | 85
decreased circulating triglyce... 1 | 83
decreased exploration in new e... 1 | 9
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased leukocyte cell numbe... 1 | 54
decreased mean corpuscular vol... 1 | 50
decreased rib number 1 | 59
decreased thermal nociceptive ... 1 | 4
embryonic lethality prior to o... 1 | 148
female infertility 1 | 34
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased plasma cell number 1 | 5
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
irregularly shaped pupil 1 | 7
narrow eye opening 1 | 15
short tibia 1 | 82
tremors 1 | 34

Disease

osteosarcoma 40 | 7,933
ovarian cancer 36 | 8,484
Cancer 35 | 2,346
psoriasis 32 | 6,685
medulloblastoma, large-cell 24 | 6,234
lung cancer 23 | 4,466
glioblastoma 22 | 5,572
Breast cancer 17 | 3,094
atypical teratoid / rhabdoid tumor 17 | 4,369
Prostatic Neoplasms 14 | 471
diabetes mellitus 14 | 1,663
group 4 medulloblastoma 13 | 1,875
Mammary Neoplasms 12 | 410
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
invasive ductal carcinoma 12 | 2,950
primitive neuroectodermal tumor 12 | 3,031
subependymal giant cell astrocytoma 12 | 2,287
Rheumatoid Arthritis 11 | 1,160
astrocytoma 11 | 1,493
group 3 medulloblastoma 11 | 2,254
lung adenocarcinoma 11 | 2,713
Carcinoma 10 | 2,147
Multiple myeloma 10 | 1,327
malignant mesothelioma 10 | 3,162
oligodendroglioma 10 | 2,849
tuberculosis 10 | 1,557
Vascular disease 9 | 281
adult high grade glioma 9 | 2,148
colon cancer 9 | 1,475
lung carcinoma 9 | 2,844
Endometriosis 8 | 535
Obesity 8 | 616
interstitial cystitis 8 | 2,299
pediatric high grade glioma 8 | 2,712
pilocytic astrocytoma 8 | 3,086
pituitary cancer 8 | 1,972
Waldenstrons macroglobulinemia 7 | 765
acute myeloid leukemia 7 | 780
acute quadriplegic myopathy 7 | 1,157
astrocytic glioma 7 | 2,241
breast carcinoma 7 | 1,614
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
non-small cell lung cancer 7 | 2,798
spina bifida 7 | 1,064
Alzheimer's disease 6 | 644
Kidney disease 6 | 396
Primary cutaneous T-cell lymphoma 6 | 24
Prostate cancer 6 | 172
pancreatic cancer 6 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
ulcerative colitis 6 | 2,087
Arthritis 5 | 248
Hyperglycemia 5 | 120
Intellectual disability 5 | 573
Parkinson's disease 5 | 364
dermatomyositis 5 | 933
ductal carcinoma in situ 5 | 1,745
ependymoma 5 | 2,514
Adenoid Cystic Carcinoma 4 | 99
Bipolar Disorder 4 | 266
Brain disease 4 | 83
Crohn's disease 4 | 304
Hypogonadism 4 | 70
Infertility 4 | 163
Liver carcinoma 4 | 217
Lung Neoplasms 4 | 171
Metabolic syndrome X 4 | 155
Pick disease 4 | 1,893
aldosterone-producing adenoma 4 | 664
atypical teratoid/rhabdoid tumor 4 | 1,095
fibroadenoma 4 | 557
inflammatory breast cancer 4 | 404
juvenile dermatomyositis 4 | 1,189
pancreatic carcinoma 4 | 567
sonic hedgehog group medulloblastoma 4 | 1,482
Amyotrophic Lateral Sclerosis 3 | 431
Bladder Neoplasm 3 | 109
Cocaine-Related Disorders 3 | 88
Colonic Neoplasms 3 | 126
Down syndrome 3 | 548
Gaucher disease type 1 3 | 171
Heart disease 3 | 279
Huntington's disease 3 | 72
Kennedy's disease 3 | 13
Lung disease 3 | 132
Malignant neoplasm of prostate 3 | 67
Multiple Sclerosis 3 | 498
Neoplasm Metastasis 3 | 138
Neurodegenerative disease 3 | 383
Reperfusion Injury 3 | 84
Schizophrenia 3 | 501
Stomach Neoplasms 3 | 282
Toxic encephalopathy 3 | 131
active Crohn's disease 3 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
gastric carcinoma 3 | 832
glioblastoma multiforme 3 | 347
posterior fossa group A ependymoma 3 | 1,511
primary pancreatic ductal adenocarcinoma 3 | 1,271

Tissue

Blood and immune system 54 | 17,995
Cardiovascular System 54 | 17,958
Digestive Tract 54 | 18,473
Endocrine System 54 | 18,512
Female tissues 54 | 18,647
Liver and Pancreas 54 | 18,136
Male tissues 54 | 17,969
Nervous System 54 | 18,561
Skin and soft tissues 54 | 18,115
Urinary Tract 54 | 18,444
Respiratory system 53 | 17,484

Target Family

Epigenetic 12 | 242
Transcription Factor 12 | 1,400
Nuclear Receptor 8 | 48
Kinase 7 | 634
Non-IDG 7 | 11,971
Enzyme 6 | 4,146
TF/Epigenetic 2 | 38

PathwayCommons: pid Pathway

Regulation of Androgen recepto... 54 | 54
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A Tchem Enzyme -1.87754 73.1 142
Nuclear receptor subfamily 0 group B member 1 NR0B1 Tchem Nuclear Receptor -2.70036 522.8 435
Probable global transcription activator SNF2L2 SMARCA2 Tchem Epigenetic -2.53909 331.1 154
POU domain, class 2, transcription factor 1 POU2F1 Tchem Transcription Factor -2.13126 135.4 444
Histone acetyltransferase p300 EP300 Tchem Epigenetic -3.75838 5701.8 723
Transcription intermediary factor 1-alpha TRIM24 Tchem Epigenetic -2.10736 137.1 295
Nuclear receptor subfamily 2 group C member 2 NR2C2 Tchem Nuclear Receptor -1.63734 43.4 403
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -2.96006 1000.8 1343