Development Level

Tbio 38 | 10,625
Tchem 19 | 1,890
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 6 | 633
decreased lean body mass 3 | 195
abnormal bone structure 2 | 131
decreased bone mineral content 2 | 157
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 77
decreased circulating choleste... 2 | 85
decreased circulating glucose ... 2 | 121
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased mean corpuscular hem... 2 | 34
enlarged heart 2 | 111
increased body weight 2 | 42
increased mean corpuscular vol... 2 | 91
abnormal QRS complex 1 | 25
abnormal behavior 1 | 226
abnormal epididymis morphology 1 | 31
abnormal forced expiratory flo... 1 | 1
abnormal heart morphology 1 | 51
abnormal respiratory quotient 1 | 9
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 17
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
brachydactyly 1 | 2
decreased body temperature 1 | 2
decreased body weight 1 | 174
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating free fat... 1 | 39
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased effector memory CD8-... 1 | 24
decreased fasted circulating g... 1 | 49
decreased heart weight 1 | 44
decreased leukocyte cell numbe... 1 | 54
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
decreased tidal volume 1 | 1
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
enlarged epididymis 1 | 27
enlarged kidney 1 | 7
enlarged spleen 1 | 26
improved glucose tolerance 1 | 56
increased blood urea nitrogen ... 1 | 44
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating calcium ... 1 | 32
increased circulating glycerol... 1 | 11
increased circulating phosphat... 1 | 24
increased circulating total pr... 1 | 20
increased grip strength 1 | 83
increased heart weight 1 | 37
increased leukocyte cell numbe... 1 | 37
increased lymphocyte cell numb... 1 | 9
increased monocyte cell number 1 | 27
long tibia 1 | 13
preweaning lethality, incomple... 1 | 260
small heart 1 | 8
small kidney 1 | 10
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 11
small testis 1 | 37
tremors 1 | 34

Disease

Cancer 39 | 2,346
medulloblastoma, large-cell 38 | 6,234
glioblastoma 37 | 5,572
ovarian cancer 35 | 8,484
psoriasis 33 | 6,685
osteosarcoma 31 | 7,933
atypical teratoid / rhabdoid tumor 28 | 4,369
pediatric high grade glioma 24 | 2,712
primitive neuroectodermal tumor 24 | 3,031
lung cancer 22 | 4,466
oligodendroglioma 20 | 2,849
ependymoma 19 | 2,514
pilocytic astrocytoma 19 | 3,086
Carcinoma 17 | 2,147
malignant mesothelioma 17 | 3,162
astrocytoma 16 | 1,493
lung carcinoma 15 | 2,844
Mammary Neoplasms 14 | 410
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
pituitary cancer 14 | 1,972
Alzheimer's disease 13 | 644
Pick disease 13 | 1,893
invasive ductal carcinoma 13 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
non-small cell lung cancer 12 | 2,798
Breast cancer 11 | 3,094
pancreatic cancer 11 | 2,300
primary pancreatic ductal adenocarcinoma 11 | 1,271
sonic hedgehog group medulloblastoma 11 | 1,482
Multiple myeloma 10 | 1,327
Rheumatoid Arthritis 10 | 1,160
adult high grade glioma 10 | 2,148
astrocytic glioma 10 | 2,241
juvenile dermatomyositis 10 | 1,189
subependymal giant cell astrocytoma 10 | 2,287
acute quadriplegic myopathy 9 | 1,157
adrenocortical carcinoma 9 | 1,427
interstitial cystitis 9 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
medulloblastoma 9 | 1,524
Adenoid Cystic Carcinoma 8 | 99
Waldenstrons macroglobulinemia 8 | 765
ductal carcinoma in situ 8 | 1,745
group 3 medulloblastoma 8 | 2,254
Duchenne muscular dystrophy 7 | 602
Squamous cell carcinoma of esophagus 7 | 82
breast carcinoma 7 | 1,614
diabetes mellitus 7 | 1,663
Carcinoma, Pancreatic Ductal 6 | 19
Hajdu-Cheney syndrome 6 | 8
Lung Neoplasms 6 | 171
acute myeloid leukemia 6 | 780
atypical teratoid/rhabdoid tumor 6 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 499
colon cancer 6 | 1,475
dermatomyositis 6 | 933
gastric carcinoma 6 | 832
group 4 medulloblastoma 6 | 1,875
lung adenocarcinoma 6 | 2,713
nasopharyngeal carcinoma 6 | 1,056
posterior fossa group A ependymoma 6 | 1,511
tuberculosis 6 | 1,557
Endometriosis 5 | 535
non-small cell lung carcinoma 5 | 413
posterior fossa group B ependymoma 5 | 1,530
Alagille syndrome 4 | 15
Animal Mammary Neoplasms 4 | 136
Bladder Neoplasm 4 | 109
Cadasil 4 | 9
Carcinoma, Transitional Cell 4 | 31
Cerebrovascular disease 4 | 231
Colonic Neoplasms 4 | 126
Colorectal Neoplasms 4 | 217
Down syndrome 4 | 548
Immune system cancer 4 | 38
Liver carcinoma 4 | 217
Mammary Neoplasms, Experimental 4 | 150
Neurodegenerative disease 4 | 383
Stomach Neoplasms 4 | 282
cutaneous lupus erythematosus 4 | 1,056
cystic fibrosis 4 | 1,665
inflammatory breast cancer 4 | 404
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
ulcerative colitis 4 | 2,087
Adenoma 3 | 165
Allergic rhinitis 3 | 91
Amyotrophic Lateral Sclerosis 3 | 431
Atopic dermatitis 3 | 944
Crohn's disease 3 | 304
IGA Glomerulonephritis 3 | 454
Kidney disease 3 | 396
Multiple Sclerosis 3 | 498
Neuroblastoma 3 | 78
Prostate cancer 3 | 172
Prostatic Neoplasms 3 | 471
Schizophrenia 3 | 501
fibroadenoma 3 | 557
progressive supranuclear palsy 3 | 674
spina bifida 3 | 1,064
tuberculosis and treatment for 6 months 3 | 686

Tissue

Blood and immune system 58 | 17,995
Cardiovascular System 58 | 17,958
Digestive Tract 58 | 18,473
Endocrine System 58 | 18,512
Female tissues 58 | 18,647
Liver and Pancreas 58 | 18,136
Male tissues 58 | 17,969
Nervous System 58 | 18,561
Respiratory system 58 | 17,484
Skin and soft tissues 58 | 18,115
Urinary Tract 58 | 18,444

Target Family

Non-IDG 30 | 11,971
Enzyme 18 | 4,146
Transcription Factor 6 | 1,400
Epigenetic 3 | 242
Kinase 1 | 634

PathwayCommons: pid Pathway

Notch signaling pathway 58 | 58
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Contactin-6 CNTN6 Tbio Non-IDG -2.02527 101.3 65
Ras-related protein Rab-11A RAB11A Tbio Enzyme -2.60207 398.9 288
Transcriptional repressor protein YY1 YY1 Tbio Transcription Factor -2.75991 594.0 437
Delta-like protein 3 DLL3 Tbio Non-IDG -1.58510 42.7 181
Mastermind-like protein 2 MAML2 Tbio Non-IDG -1.73604 61.8 100
G1/S-specific cyclin-D1 CCND1 Tchem Non-IDG -3.77851 5447.1 1111
Delta and Notch-like epidermal growth factor-related receptor DNER Tbio Non-IDG -1.59708 45.6 159
Cyclin-dependent kinase inhibitor 1 CDKN1A Tbio Enzyme -3.43357 2997.4 1177
E3 ubiquitin-protein ligase NEURL1 NEURL1 Tbio Enzyme -1.00652 11.1 153
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84502 678.2 177