Development Level

Tchem 26 | 1,890
Tbio 17 | 10,625
Tclin 11 | 602

IMPC Phenotype

preweaning lethality, complete... 4 | 633
abnormal bone structure 2 | 131
decreased bone mineral content 2 | 157
increased lean body mass 2 | 107
abnormal coping response 1 | 12
abnormal gait 1 | 51
abnormal joint morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal optic disc morphology 1 | 10
cataract 1 | 26
decreased CD4-positive NK T ce... 1 | 4
decreased Ly6C-positive immatu... 1 | 4
decreased Ly6C-positive mature... 1 | 4
decreased body weight 1 | 174
decreased circulating iron lev... 1 | 25
decreased large unstained cell... 1 | 3
decreased lean body mass 1 | 195
decreased leukocyte cell numbe... 1 | 54
decreased lymphocyte cell numb... 1 | 9
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased memory-marker CD4-ne... 1 | 4
decreased memory-marker CD4-po... 1 | 4
decreased total body fat amoun... 1 | 186
enlarged lymph nodes 1 | 27
immune system phenotype 1 | 17
increased CD11b-high dendritic... 1 | 5
increased CD4-negative NK T ce... 1 | 4
increased body length 1 | 20
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased effector memory CD8-... 1 | 14
increased monocyte cell number 1 | 27
increased neutrophil cell numb... 1 | 15
short tibia 1 | 82

Disease

Cancer 45 | 2,346
osteosarcoma 35 | 7,933
ovarian cancer 35 | 8,491
psoriasis 33 | 6,685
medulloblastoma, large-cell 31 | 6,234
glioblastoma 30 | 5,572
lung cancer 23 | 4,473
atypical teratoid / rhabdoid tumor 22 | 4,369
Rheumatoid Arthritis 19 | 1,170
invasive ductal carcinoma 18 | 2,950
pilocytic astrocytoma 18 | 3,086
Multiple myeloma 16 | 1,327
Breast cancer 15 | 3,098
Carcinoma 15 | 2,147
diabetes mellitus 15 | 1,663
group 4 medulloblastoma 15 | 1,875
lung adenocarcinoma 15 | 2,714
Lung Neoplasms 14 | 171
interstitial cystitis 14 | 2,299
lung carcinoma 14 | 2,844
malignant mesothelioma 14 | 3,163
ulcerative colitis 14 | 2,087
Stomach Neoplasms 13 | 282
astrocytoma 13 | 1,493
non-small cell lung cancer 13 | 2,798
pituitary cancer 13 | 1,972
Asthma 12 | 349
Vascular disease 12 | 281
ductal carcinoma in situ 12 | 1,745
juvenile dermatomyositis 12 | 1,189
medulloblastoma 12 | 1,524
oligodendroglioma 12 | 2,849
primitive neuroectodermal tumor 12 | 3,031
Alzheimer's disease 11 | 644
Arthritis 11 | 248
Multiple Sclerosis 11 | 498
adult high grade glioma 11 | 2,148
breast carcinoma 11 | 1,614
ependymoma 11 | 2,514
pancreatic cancer 11 | 2,300
Liver carcinoma 10 | 217
Mammary Neoplasms 10 | 410
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,289
pediatric high grade glioma 10 | 2,712
subependymal giant cell astrocytoma 10 | 2,287
tuberculosis 10 | 1,563
Heart disease 9 | 279
Liver neoplasms 9 | 108
Melanoma 9 | 261
Noonan Syndrome 9 | 33
Pick disease 9 | 1,893
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
Atopic dermatitis 8 | 944
Kidney disease 8 | 397
Lung disease 8 | 136
Neoplasm Metastasis 8 | 138
Obesity 8 | 616
chronic lymphocytic leukemia 8 | 244
cutaneous lupus erythematosus 8 | 1,056
pancreatic carcinoma 8 | 567
primary Sjogren syndrome 8 | 788
Cardiofaciocutaneous syndrome 7 | 15
Costello Syndrome 7 | 18
Dermatitis, Allergic Contact 7 | 66
Hepatitis C 7 | 90
Hypersensitivity reaction type II disease 7 | 235
Prostatic Neoplasms 7 | 471
Reperfusion Injury 7 | 84
Waldenstrons macroglobulinemia 7 | 764
acute quadriplegic myopathy 7 | 1,157
adrenocortical carcinoma 7 | 1,427
astrocytic glioma 7 | 2,241
dermatomyositis 7 | 966
hepatocellular carcinoma 7 | 550
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
nasopharyngeal carcinoma 7 | 1,056
non-small cell lung carcinoma 7 | 413
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
posterior fossa group A ependymoma 7 | 1,511
Acquired immunodeficiency syndrome 6 | 164
Autistic Disorder 6 | 320
Cardiomyopathies 6 | 90
Colonic Neoplasms 6 | 126
Colorectal Neoplasms 6 | 217
Crohn's disease 6 | 304
Hepatitis 6 | 61
Immune system cancer 6 | 38
LEOPARD Syndrome 6 | 20
Lymphoid leukemia 6 | 69
Neoplastic Cell Transformation 6 | 81
Parkinson's disease 6 | 364
Severe Combined Immunodeficiency 6 | 46
Squamous cell carcinoma 6 | 96
colon cancer 6 | 1,475
group 3 medulloblastoma 6 | 2,254
ovarian neoplasm 6 | 97
primary pancreatic ductal adenocarcinoma 6 | 1,271
sarcoidosis 6 | 368
acute myeloid leukemia 5 | 785
aldosterone-producing adenoma 5 | 664

Tissue

Blood and immune system 54 | 17,994
Cardiovascular System 54 | 17,957
Digestive Tract 54 | 18,472
Endocrine System 54 | 18,511
Female tissues 54 | 18,646
Male tissues 54 | 17,968
Nervous System 54 | 18,560
Respiratory system 54 | 17,483
Skin and soft tissues 54 | 18,114
Urinary Tract 54 | 18,443
Liver and Pancreas 53 | 18,135

Target Family

Kinase 21 | 634
Non-IDG 19 | 11,969
Transcription Factor 8 | 1,400
Enzyme 6 | 4,146

PathwayCommons: pid Pathway

IL2-mediated signaling events 54 | 54
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
GTPase KRas KRAS Tbio Enzyme -3.77389 5694.2 421
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.75815 5706.6 1539
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.09050 11730.8 2241
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.12726 13094.7 961
GTPase HRas HRAS Tchem Enzyme -3.99319 9497.9 312
GTPase NRas NRAS Tchem Enzyme -2.98048 880.4 265
RAF proto-oncogene serine/threonine-protein kinase RAF1 Tclin Kinase -3.09190 1147.5 1943
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.11789 1349.3 1026
Signal transducer and activator of transcription 1-alpha/beta STAT1 Tchem Transcription Factor -3.29893 1889.3 1357