Development Level

Tbio 29 | 10,625
Tchem 14 | 1,890
Tclin 6 | 602

Collection

Eligible Kinase Proteins 4 | 134

IMPC Term

preweaning lethality, complete... 8 | 633
embryonic lethality prior to t... 4 | 187
abnormal embryo size 3 | 112
decreased bone mineral content 3 | 157
abnormal QRS complex 2 | 25
abnormal behavior 2 | 226
abnormal embryo turning 2 | 15
decreased lean body mass 2 | 195
decreased respiratory quotient 2 | 12
hyperactivity 2 | 108
abnormal bone structure 1 | 131
abnormal cranium morphology 1 | 32
abnormal embryo development 1 | 2
abnormal eye morphology 1 | 38
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal limb bud morphology 1 | 15
abnormal liver size 1 | 4
abnormal maxilla morphology 1 | 16
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pericardium morpholog... 1 | 11
abnormal placenta size 1 | 10
abnormal skin appearance 1 | 8
abnormal spinal cord morpholog... 1 | 8
abnormal spleen morphology 1 | 36
abnormal stomach morphology 1 | 4
abnormal tooth morphology 1 | 24
absent heartbeat 1 | 6
anophthalmia 1 | 20
decreased body weight 1 | 174
decreased circulating glucose ... 1 | 121
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased mean corpuscular vol... 1 | 50
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
embryonic growth retardation 1 | 28
enlarged lymph nodes 1 | 27
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating creatini... 1 | 29
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased eosinophil cell numb... 1 | 9
increased grip strength 1 | 83
increased heart rate variabili... 1 | 4
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
limb grasping 1 | 35
pale liver 1 | 5
pale yolk sac 1 | 12
pallor 1 | 13
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
small adrenal glands 1 | 15
small thymus 1 | 11
thrombocytopenia 1 | 46

Disease

ovarian cancer 35 | 8,492
osteosarcoma 32 | 7,933
glioblastoma 25 | 5,572
medulloblastoma, large-cell 25 | 6,234
atypical teratoid / rhabdoid tumor 20 | 4,369
psoriasis 19 | 6,685
Cancer 18 | 2,346
lung cancer 14 | 4,473
subependymal giant cell astrocytoma 14 | 2,287
Carcinoma 13 | 2,147
ependymoma 13 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,988
oligodendroglioma 12 | 2,849
Breast cancer 11 | 3,099
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,956
malignant mesothelioma 11 | 3,163
pancreatic cancer 11 | 2,300
sonic hedgehog group medulloblastoma 11 | 1,482
Multiple myeloma 10 | 1,328
group 4 medulloblastoma 10 | 1,875
lung carcinoma 10 | 2,844
astrocytoma 9 | 1,493
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
primitive neuroectodermal tumor 9 | 3,031
Polydactyly 8 | 93
colon cancer 8 | 1,475
group 3 medulloblastoma 8 | 2,254
invasive ductal carcinoma 8 | 2,950
pediatric high grade glioma 8 | 2,712
Nevoid basal cell carcinoma syndrome 7 | 9
Pick disease 7 | 1,893
adult high grade glioma 7 | 2,148
breast carcinoma 7 | 1,614
medulloblastoma 7 | 1,524
primary pancreatic ductal adenocarcinoma 7 | 1,271
Holoprosencephaly 6 | 52
Rheumatoid Arthritis 6 | 1,171
acute quadriplegic myopathy 6 | 1,157
astrocytic glioma 6 | 2,241
dermatomyositis 6 | 967
non-small cell lung cancer 6 | 2,798
pilocytic astrocytoma 6 | 3,086
posterior fossa group A ependymoma 6 | 1,511
Parkinson's disease 5 | 364
Waldenstrons macroglobulinemia 5 | 765
diabetes mellitus 5 | 1,663
interstitial cystitis 5 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
Acute Promyelocytic Leukemia 4 | 32
Asthma 4 | 349
Basal cell carcinoma 4 | 31
Duchenne muscular dystrophy 4 | 602
Pallister-Hall syndrome 4 | 11
Prostatic Neoplasms 4 | 471
Schizophrenia 4 | 503
Skin Neoplasms 4 | 49
active ulcerative colitis 4 | 477
adrenocortical carcinoma 4 | 1,427
atypical teratoid/rhabdoid tumor 4 | 1,095
chronic rhinosinusitis 4 | 512
juvenile dermatomyositis 4 | 1,189
non primary Sjogren syndrome sicca 4 | 840
Adenoma 3 | 165
Alobar Holoprosencephaly 3 | 14
Alzheimer's disease 3 | 644
Ameloblastoma 3 | 25
Amyotrophic Lateral Sclerosis 3 | 432
Basal Cell Nevus Syndrome 3 | 4
Cardiomegaly 3 | 66
Ciliopathy 3 | 57
Cleft Lip 3 | 91
Craniofacial Abnormalities 3 | 147
Endometriosis 3 | 535
Heart disease 3 | 279
Intellectual disability 3 | 573
Lobar Holoprosencephaly 3 | 14
Melanoma 3 | 261
SOLITARY MEDIAN MAXILLARY CENTRAL INCISOR 3 | 14
Semilobar Holoprosencephaly 3 | 14
Squamous cell carcinoma 3 | 96
Stomach Neoplasms 3 | 282
Synostosis 3 | 18
Vascular disease 3 | 281
active Crohn's disease 3 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
cutaneous lupus erythematosus 3 | 1,056
cystic fibrosis 3 | 1,670
ductal carcinoma in situ 3 | 1,745
lung adenocarcinoma 3 | 2,714
nasopharyngeal carcinoma 3 | 1,056
pituitary cancer 3 | 1,972
spina bifida 3 | 1,064
tuberculosis 3 | 1,563
ulcerative colitis 3 | 2,087
Atopic dermatitis 2 | 944
Chronic obstructive pulmonary disease 2 | 147
acute myeloid leukemia 2 | 785
esophageal adenocarcinoma 2 | 737
inflammatory breast cancer 2 | 404
mucosa-associated lymphoid tissue lymphoma 2 | 480

Tissue

Blood and immune system 49 | 17,995
Cardiovascular System 49 | 17,958
Digestive Tract 49 | 18,473
Endocrine System 49 | 18,512
Female tissues 49 | 18,647
Liver and Pancreas 49 | 18,136
Male tissues 49 | 17,969
Nervous System 49 | 18,561
Respiratory system 49 | 17,484
Skin and soft tissues 49 | 18,115
Urinary Tract 49 | 18,444

Target Family

Non-IDG 25 | 11,969
Kinase 12 | 634
Transcription Factor 5 | 1,400
Enzyme 3 | 4,146
Epigenetic 3 | 242
GPCR 1 | 408

PathwayCommons: pid Pathway

Hedgehog signaling events medi... 49 | 49
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Kinesin-like protein KIF3A KIF3A Tbio Non-IDG -2.03835 107.4 139
Smoothened homolog SMO Tclin GPCR -1.11229 12.5 388
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.04744 808.6 1868
Galectin-3 LGALS3 Tchem Non-IDG -3.33005 2249.5 911
Ras-related protein Rab-23 RAB23 Tbio Enzyme -1.57748 43.0 190
Casein kinase I isoform gamma-3 CSNK1G3 Tbio Kinase -1.03141 9.69 121
Protein patched homolog 1 PTCH1 Tbio Non-IDG -3.02316 1236.4 412
F-box/WD repeat-containing protein 11 FBXW11 Tbio Non-IDG -0.70213 5.61 153
Casein kinase I isoform gamma-1 CSNK1G1 Tbio Kinase -0.49391 3.22 194