Development Level

Tchem 16 | 1,890
Tbio 14 | 10,625
Tclin 4 | 602

IMPC Term

preweaning lethality, complete... 2 | 633
abnormal embryo size 1 | 112
abnormal heart morphology 1 | 51
abnormal iris morphology 1 | 12
abnormal maxilla morphology 1 | 16
abnormal placement of pupils 1 | 4
abnormal retinal pigmentation 1 | 61
abnormal snout morphology 1 | 18
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
decreased blood urea nitrogen ... 1 | 31
decreased circulating chloride... 1 | 32
decreased fasted circulating g... 1 | 49
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased rib number 1 | 59
decreased total body fat amoun... 1 | 186
embryonic growth retardation 1 | 28
embryonic lethality prior to o... 1 | 148
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
irregularly shaped pupil 1 | 7
narrow eye opening 1 | 15
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 27 | 8,484
Cancer 24 | 2,346
osteosarcoma 20 | 7,933
glioblastoma 15 | 5,572
lung cancer 15 | 4,466
medulloblastoma, large-cell 14 | 6,234
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,289
psoriasis 13 | 6,685
atypical teratoid / rhabdoid tumor 12 | 4,369
invasive ductal carcinoma 12 | 2,950
non-small cell lung cancer 12 | 2,798
lung adenocarcinoma 11 | 2,713
pancreatic cancer 11 | 2,300
diabetes mellitus 10 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
malignant mesothelioma 10 | 3,162
primary pancreatic ductal adenocarcinoma 9 | 1,271
ulcerative colitis 9 | 2,087
Mammary Neoplasms 8 | 410
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
lung carcinoma 8 | 2,844
Breast cancer 7 | 3,094
Renal Cell Carcinoma 7 | 199
adrenocortical carcinoma 7 | 1,427
posterior fossa group A ependymoma 7 | 1,511
Cerebrovascular disease 6 | 231
Diabetic Retinopathy 6 | 53
Heart disease 6 | 279
Hemangioma 6 | 35
Multiple myeloma 6 | 1,327
Obesity 6 | 616
astrocytoma 6 | 1,493
cystic fibrosis 6 | 1,665
pediatric high grade glioma 6 | 2,712
pilocytic astrocytoma 6 | 3,086
Carcinoma 5 | 2,147
Hyperglycemia 5 | 120
Hypertension 5 | 287
Melanoma 5 | 261
Neoplasm Metastasis 5 | 138
Polycythemia 5 | 19
Prostatic Neoplasms 5 | 471
Rheumatoid Arthritis 5 | 1,160
Vascular disease 5 | 281
Waldenstrons macroglobulinemia 5 | 765
acute quadriplegic myopathy 5 | 1,157
ductal carcinoma in situ 5 | 1,745
oligodendroglioma 5 | 2,849
primitive neuroectodermal tumor 5 | 3,031
urothelial carcinoma 5 | 318
Anemia 4 | 252
Atherosclerosis 4 | 275
Colorectal Neoplasms 4 | 217
Coronary artery disease 4 | 240
Diabetes Mellitus, Non-Insulin-Dependent 4 | 157
Heart Diseases 4 | 42
Kidney cancer 4 | 118
Kidney disease 4 | 396
Neoplasm Invasiveness 4 | 127
Neurodegenerative disease 4 | 383
Retinopathy of prematurity 4 | 21
acute myeloid leukemia 4 | 780
astrocytic glioma 4 | 2,241
breast carcinoma 4 | 1,614
pituitary cancer 4 | 1,972
sonic hedgehog group medulloblastoma 4 | 1,482
tuberculosis 4 | 1,557
Acute kidney injury 3 | 65
Adenoma 3 | 165
Arthritis 3 | 248
Atopic dermatitis 3 | 944
Capillary hemangioma 3 | 11
Diabetes Mellitus, Experimental 3 | 106
Huntington's disease 3 | 72
Keratitis 3 | 42
Liver carcinoma 3 | 217
Liver disease 3 | 219
Lung disease 3 | 132
Metabolic syndrome X 3 | 155
Myocardial Ischemia 3 | 169
Neutropenia 3 | 78
Parkinson's disease 3 | 364
Peripheral vascular disease 3 | 90
Proteinuria 3 | 63
Schizophrenia 3 | 501
Seizures 3 | 95
Stomach Neoplasms 3 | 282
adult high grade glioma 3 | 2,148
aldosterone-producing adenoma 3 | 664
atypical teratoid/rhabdoid tumor 3 | 1,095
colon cancer 3 | 1,475
cutaneous lupus erythematosus 3 | 1,056
dermatomyositis 3 | 933
ependymoma 3 | 2,514
gastric carcinoma 3 | 832
interstitial cystitis 3 | 2,299
nervous system disorder 3 | 53
non-small cell lung carcinoma 3 | 413
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis and treatment for 3 months 3 | 327

Tissue

Blood and immune system 34 | 17,995
Cardiovascular System 34 | 17,958
Digestive Tract 34 | 18,473
Endocrine System 34 | 18,512
Female tissues 34 | 18,647
Liver and Pancreas 34 | 18,136
Male tissues 34 | 17,969
Nervous System 34 | 18,561
Respiratory system 34 | 17,484
Skin and soft tissues 34 | 18,115
Urinary Tract 34 | 18,444

Target Family

Non-IDG 13 | 11,971
Transcription Factor 7 | 1,400
Kinase 4 | 634
Enzyme 3 | 4,146
Epigenetic 3 | 242
Transporter 3 | 473
GPCR 1 | 406

PathwayCommons: pid Pathway

HIF-2-alpha transcription fact... 34 | 34
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Phosphoglycerate kinase 1 PGK1 Tchem Kinase -2.77086 576.3 300
Eukaryotic translation initiation factor 3 subunit E EIF3E Tbio Non-IDG -1.39943 28.0 202
POU domain, class 5, transcription factor 1 POU5F1 Tbio Transcription Factor -3.28204 1980.8 817
Aryl hydrocarbon receptor nuclear translocator ARNT Tbio Transcription Factor -2.49893 243.3 424
Matrix metalloproteinase-14 MMP14 Tchem Enzyme -2.98014 1049.9 668
Natural resistance-associated macrophage protein 2 SLC11A2 Tchem Transporter -2.50852 352.2 235
Histone acetyltransferase p300 EP300 Tchem Epigenetic -3.75838 5701.8 723
Von Hippel-Lindau disease tumor suppressor VHL Tchem Enzyme -2.44720 283.9 450
Vascular endothelial growth factor receptor 1 FLT1 Tclin Kinase -3.34036 2061.0 806