Development Level

Tchem 34 | 1,890
Tbio 28 | 10,625
Tclin 5 | 602

IMPC Term

decreased total body fat amoun... 3 | 186
decreased fasted circulating g... 2 | 49
preweaning lethality, complete... 2 | 633
abnormal epididymis morphology 1 | 31
abnormal ovary morphology 1 | 3
abnormal sleep behavior 1 | 63
abnormal vibrissa morphology 1 | 17
absent epididymis 1 | 2
brachydactyly 1 | 2
decreased blood urea nitrogen ... 1 | 31
decreased circulating HDL chol... 1 | 77
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating choleste... 1 | 85
decreased circulating iron lev... 1 | 25
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lactate dehydrogenas... 1 | 14
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
embryonic lethality prior to t... 1 | 187
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased total body fat amoun... 1 | 57
preweaning lethality, incomple... 1 | 260

Disease

Cancer 59 | 2,346
ovarian cancer 49 | 8,484
psoriasis 41 | 6,685
osteosarcoma 40 | 7,933
glioblastoma 39 | 5,572
medulloblastoma, large-cell 38 | 6,234
pancreatic cancer 33 | 2,300
lung cancer 31 | 4,466
non-small cell lung cancer 29 | 2,798
diabetes mellitus 27 | 1,663
invasive ductal carcinoma 27 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,289
lung carcinoma 25 | 2,844
ulcerative colitis 25 | 2,087
malignant mesothelioma 23 | 3,162
atypical teratoid / rhabdoid tumor 22 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,988
Breast cancer 21 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,956
primary pancreatic ductal adenocarcinoma 21 | 1,271
lung adenocarcinoma 20 | 2,713
Mammary Neoplasms 19 | 410
breast carcinoma 19 | 1,614
Obesity 18 | 616
pilocytic astrocytoma 17 | 3,086
acute quadriplegic myopathy 16 | 1,157
astrocytoma 16 | 1,493
cystic fibrosis 16 | 1,665
pediatric high grade glioma 16 | 2,712
posterior fossa group A ependymoma 16 | 1,511
primitive neuroectodermal tumor 16 | 3,031
Waldenstrons macroglobulinemia 15 | 765
ductal carcinoma in situ 15 | 1,745
interstitial cystitis 15 | 2,299
pituitary cancer 15 | 1,972
Kidney disease 14 | 396
Rheumatoid Arthritis 14 | 1,160
dermatomyositis 14 | 933
group 4 medulloblastoma 14 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
Alzheimer's disease 13 | 644
Multiple myeloma 13 | 1,327
Hyperglycemia 12 | 120
Liver Cirrhosis, Experimental 12 | 108
Prostatic Neoplasms 12 | 471
gastric carcinoma 12 | 832
subependymal giant cell astrocytoma 12 | 2,287
Arthritis 11 | 248
Atopic dermatitis 11 | 944
Cerebrovascular disease 11 | 231
Liver carcinoma 11 | 217
Vascular disease 11 | 281
adrenocortical carcinoma 11 | 1,427
adult high grade glioma 11 | 2,148
aldosterone-producing adenoma 11 | 664
colon cancer 11 | 1,475
ependymoma 11 | 2,514
Anemia 10 | 252
Carcinoma 10 | 2,147
Heart disease 10 | 279
Liver disease 10 | 219
Myocardial Ischemia 10 | 169
Pick disease 10 | 1,893
Schizophrenia 10 | 501
Stomach Neoplasms 10 | 282
esophageal adenocarcinoma 10 | 737
oligodendroglioma 10 | 2,849
Coronary artery disease 9 | 240
Diabetes Mellitus, Non-Insulin-Dependent 9 | 157
Hyperinsulinism 9 | 63
Hypertension 9 | 287
Inflammation 9 | 109
Neoplasm Invasiveness 9 | 127
Neoplasm Metastasis 9 | 138
acute myeloid leukemia 9 | 780
atypical teratoid/rhabdoid tumor 9 | 1,095
juvenile dermatomyositis 9 | 1,189
mucosa-associated lymphoid tissue lymphoma 9 | 480
tuberculosis 9 | 1,557
tuberculosis and treatment for 3 months 9 | 327
Asthma 8 | 349
Hypertensive disease 8 | 193
Lung Neoplasms 8 | 171
Lung disease 8 | 132
Metabolic syndrome X 8 | 155
astrocytic glioma 8 | 2,241
cutaneous lupus erythematosus 8 | 1,056
fibroadenoma 8 | 557
group 3 medulloblastoma 8 | 2,254
Adenoma 7 | 165
Atherosclerosis 7 | 275
Autistic Disorder 7 | 320
Colonic Neoplasms 7 | 126
Colorectal Neoplasms 7 | 217
Duchenne muscular dystrophy 7 | 602
Endometriosis 7 | 535
Neurodegenerative disease 7 | 383
Reperfusion Injury 7 | 84
medulloblastoma 7 | 1,524
primary Sjogren syndrome 7 | 789

Tissue

Digestive Tract 67 | 18,473
Liver and Pancreas 67 | 18,136
Blood and immune system 66 | 17,995
Cardiovascular System 66 | 17,958
Endocrine System 66 | 18,512
Female tissues 66 | 18,647
Male tissues 66 | 17,969
Nervous System 66 | 18,561
Respiratory system 66 | 17,484
Skin and soft tissues 66 | 18,115
Urinary Tract 66 | 18,444

Target Family

Non-IDG 24 | 11,971
Transcription Factor 13 | 1,400
Enzyme 11 | 4,146
Kinase 8 | 634
Epigenetic 4 | 242
Transporter 4 | 473
Nuclear Receptor 2 | 48
GPCR 1 | 406

PathwayCommons: pid Pathway

HIF-1-alpha transcription fact... 67 | 67
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Pyruvate kinase PKM PKM Tchem Kinase -3.09101 1313.5 672
Serotransferrin TF Tchem Non-IDG -4.13136 13124.3 952
Transferrin receptor protein 1 TFRC Tbio Non-IDG -3.39868 2437.0 1167
Phosphoglycerate kinase 1 PGK1 Tchem Kinase -2.77086 576.3 300
Nuclear receptor ROR-alpha RORA Tchem Nuclear Receptor -2.17386 139.2 340
Nitric oxide synthase, inducible NOS2 Tchem Enzyme -3.32560 2206.3 649
ADM ADM Tchem Non-IDG -3.25380 1832.5 293
L-lactate dehydrogenase A chain LDHA Tchem Enzyme -2.99664 983.0 487