Development Level

Tchem 36 | 1,890
Tbio 19 | 10,625
Tclin 9 | 602

IMPC Term

preweaning lethality, complete... 4 | 633
decreased body weight 3 | 174
preweaning lethality, incomple... 3 | 260
decreased circulating sodium l... 2 | 18
decreased total body fat amoun... 2 | 186
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal gait 1 | 51
abnormal lens morphology 1 | 73
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal skin condition 1 | 6
abnormal startle reflex 1 | 14
cataract 1 | 26
decreased circulating alanine ... 1 | 53
decreased circulating amylase ... 1 | 24
decreased circulating creatini... 1 | 31
decreased circulating fructosa... 1 | 31
decreased fasted circulating g... 1 | 49
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased thermal nociceptive ... 1 | 4
increased CD4-positive, alpha ... 1 | 15
increased body length 1 | 20
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased erythrocyte cell num... 1 | 26
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased sacral vertebrae num... 1 | 62
increased thermal nociceptive ... 1 | 9

Disease

Cancer 43 | 2,346
ovarian cancer 40 | 8,492
glioblastoma 34 | 5,572
osteosarcoma 33 | 7,933
lung cancer 29 | 4,473
medulloblastoma, large-cell 25 | 6,234
Carcinoma 22 | 2,147
psoriasis 22 | 6,685
invasive ductal carcinoma 21 | 2,950
interstitial cystitis 20 | 2,299
lung carcinoma 20 | 2,844
astrocytoma 19 | 1,493
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,988
non-small cell lung cancer 17 | 2,798
ulcerative colitis 17 | 2,087
pilocytic astrocytoma 16 | 3,086
subependymal giant cell astrocytoma 16 | 2,287
Breast cancer 14 | 3,099
atypical teratoid / rhabdoid tumor 14 | 4,369
pediatric high grade glioma 14 | 2,712
diabetes mellitus 13 | 1,663
juvenile dermatomyositis 13 | 1,189
lung adenocarcinoma 13 | 2,714
malignant mesothelioma 13 | 3,163
primary Sjogren syndrome 13 | 789
Pick disease 12 | 1,893
cutaneous lupus erythematosus 12 | 1,056
group 4 medulloblastoma 12 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
oligodendroglioma 12 | 2,849
Arthritis 11 | 248
Lung Neoplasms 11 | 171
Multiple myeloma 11 | 1,328
Rheumatoid Arthritis 11 | 1,171
Waldenstrons macroglobulinemia 11 | 765
pancreatic cancer 11 | 2,300
primitive neuroectodermal tumor 11 | 3,031
Mammary Neoplasms 10 | 410
adult high grade glioma 10 | 2,148
colon cancer 10 | 1,475
cystic fibrosis 10 | 1,670
tuberculosis 10 | 1,563
Alzheimer's disease 9 | 644
Asthma 9 | 349
IGA Glomerulonephritis 9 | 454
Stomach Neoplasms 9 | 282
ependymoma 9 | 2,514
Down syndrome 8 | 548
Noonan Syndrome 8 | 33
Vascular disease 8 | 281
adrenocortical carcinoma 8 | 1,427
breast carcinoma 8 | 1,614
medulloblastoma 8 | 1,524
Cardiofaciocutaneous syndrome 7 | 15
Costello Syndrome 7 | 18
Parkinson's disease 7 | 364
Schizophrenia 7 | 503
Toxic encephalopathy 7 | 131
group 3 medulloblastoma 7 | 2,254
Brain Ischemia 6 | 87
Heart disease 6 | 279
LEOPARD Syndrome 6 | 20
Lung disease 6 | 136
Neoplasm Invasiveness 6 | 127
Obesity 6 | 616
Squamous cell carcinoma 6 | 96
acute myeloid leukemia 6 | 785
dermatomyositis 6 | 967
ductal carcinoma in situ 6 | 1,745
esophageal adenocarcinoma 6 | 737
fibroadenoma 6 | 557
hepatocellular carcinoma 6 | 550
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
pituitary cancer 6 | 1,972
Allergic hypersensitivity disease 5 | 123
Atopic dermatitis 5 | 944
Kidney disease 5 | 397
Liver carcinoma 5 | 217
Mammary Neoplasms, Experimental 5 | 150
Neoplastic Cell Transformation 5 | 81
Renal Cell Carcinoma 5 | 199
Reperfusion Injury 5 | 84
active Crohn's disease 5 | 918
chronic lymphocytic leukemia 5 | 244
chronic lymphosyte leukemia 5 | 232
nasopharyngeal carcinoma 5 | 1,056
ovarian neoplasm 5 | 97
pancreatic carcinoma 5 | 567
posterior fossa group A ependymoma 5 | 1,511
spina bifida 5 | 1,064
tuberculosis and treatment for 6 months 5 | 686
Juvenile arthritis 4 | 124
acute quadriplegic myopathy 4 | 1,157
astrocytic glioma 4 | 2,241
mucosa-associated lymphoid tissue lymphoma 4 | 480
nephrosclerosis 4 | 329
periodontitis 4 | 269
primary pancreatic ductal adenocarcinoma 4 | 1,271
sonic hedgehog group medulloblastoma 4 | 1,482

Tissue

Blood and immune system 64 | 17,995
Cardiovascular System 64 | 17,958
Digestive Tract 64 | 18,473
Endocrine System 64 | 18,512
Female tissues 64 | 18,647
Liver and Pancreas 64 | 18,136
Male tissues 64 | 17,969
Nervous System 64 | 18,561
Respiratory system 64 | 17,484
Urinary Tract 64 | 18,444
Skin and soft tissues 63 | 18,115

Target Family

Kinase 25 | 634
Non-IDG 19 | 11,969
Enzyme 14 | 4,146
Transcription Factor 5 | 1,400
GPCR 1 | 408

PathwayCommons: pid Pathway

Fc-epsilon receptor I signalin... 64 | 64
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B Tbio Non-IDG -2.59865 595.2 386
Protein kinase C beta type PRKCB Tchem Kinase -1.97915 83.5 530
Docking protein 1 DOK1 Tbio Non-IDG -1.63889 41.5 639
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.04744 808.6 1868
Paxillin PXN Tchem Non-IDG -2.97313 849.9 1088
Nuclear factor of activated T-cells, cytoplasmic 2 NFATC2 Tbio Transcription Factor -2.40424 241.6 357
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.12726 13094.7 961
GTPase HRas HRAS Tchem Enzyme -3.99319 9497.9 312
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.62805 3186.8 1232
NF-kappa-B essential modulator IKBKG Tchem Kinase -3.05271 1121.7 849