Development Level

Tbio 25 | 10,625
Tchem 16 | 1,890
Tclin 3 | 602
Tdark 1 | 7,003

IMPC Phenotype

decreased body weight 2 | 174
impaired glucose tolerance 2 | 52
preweaning lethality, complete... 2 | 633
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal tooth morphology 1 | 24
decreased IgG1 level 1 | 4
decreased T cell number 1 | 31
decreased bone mineral content 1 | 157
decreased circulating alkaline... 1 | 41
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased lean body mass 1 | 195
embryonic lethality prior to t... 1 | 187
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased mean corpuscular vol... 1 | 91
increased vertical activity 1 | 18
limb grasping 1 | 35
persistence of hyaloid vascula... 1 | 22
preweaning lethality, incomple... 1 | 260
vertebral fusion 1 | 23

Disease

Cancer 25 | 2,346
ovarian cancer 25 | 8,491
osteosarcoma 20 | 7,933
psoriasis 20 | 6,685
lung cancer 18 | 4,473
malignant mesothelioma 15 | 3,163
medulloblastoma, large-cell 15 | 6,234
Prostatic Neoplasms 14 | 471
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
Obesity 13 | 616
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
glioblastoma 12 | 5,572
Breast cancer 11 | 3,098
Carcinoma 11 | 2,147
Mammary Neoplasms 11 | 410
lung adenocarcinoma 11 | 2,714
lung carcinoma 11 | 2,844
pituitary cancer 11 | 1,972
primitive neuroectodermal tumor 11 | 3,031
Vascular disease 10 | 281
astrocytoma 10 | 1,493
atypical teratoid / rhabdoid tumor 10 | 4,369
non-small cell lung cancer 10 | 2,798
breast carcinoma 9 | 1,614
diabetes mellitus 9 | 1,663
pancreatic cancer 9 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
Liver carcinoma 8 | 217
astrocytic glioma 8 | 2,241
ductal carcinoma in situ 8 | 1,745
group 4 medulloblastoma 8 | 1,875
invasive ductal carcinoma 8 | 2,950
Lung Neoplasms 7 | 171
Rheumatoid Arthritis 7 | 1,170
colon cancer 7 | 1,475
cystic fibrosis 7 | 1,670
interstitial cystitis 7 | 2,299
pediatric high grade glioma 7 | 2,712
ulcerative colitis 7 | 2,087
Alzheimer's disease 6 | 644
Atherosclerosis 6 | 275
Kidney disease 6 | 397
Multiple myeloma 6 | 1,327
Neoplastic Cell Transformation 6 | 81
Pick disease 6 | 1,893
Prostate cancer 6 | 172
Waldenstrons macroglobulinemia 6 | 764
ependymoma 6 | 2,514
fibroadenoma 6 | 557
group 3 medulloblastoma 6 | 2,254
oligodendroglioma 6 | 2,849
posterior fossa group A ependymoma 6 | 1,511
Adenoid Cystic Carcinoma 5 | 99
Adenoma 5 | 165
Bipolar Disorder 5 | 266
Down syndrome 5 | 548
Fatty Liver 5 | 48
Heart disease 5 | 279
Hyperglycemia 5 | 120
Hypertensive disease 5 | 193
Kidney cancer 5 | 121
Liver disease 5 | 219
Lung disease 5 | 136
Parkinson's disease 5 | 364
chronic lymphosyte leukemia 5 | 232
cutaneous lupus erythematosus 5 | 1,056
hepatocellular carcinoma 5 | 550
subependymal giant cell astrocytoma 5 | 2,287
Amyotrophic Lateral Sclerosis 4 | 432
Asthma 4 | 349
Cerebrovascular disease 4 | 231
Crohn's disease 4 | 304
Diarrhea 4 | 155
Endometriosis 4 | 535
Fatty liver disease 4 | 86
Female infertility 4 | 28
Heart failure 4 | 80
Hypoglycemia 4 | 81
Intellectual disability 4 | 573
Leukemia 4 | 88
Mammary Neoplasms, Experimental 4 | 149
Neurodegenerative disease 4 | 383
Peripheral Neuropathy 4 | 303
Pneumonia 4 | 133
Schizophrenia 4 | 503
Squamous cell carcinoma of esophagus 4 | 82
Stomach Neoplasms 4 | 282
active Crohn's disease 4 | 918
acute myeloid leukemia 4 | 785
atypical teratoid/rhabdoid tumor 4 | 1,095
esophageal adenocarcinoma 4 | 737
gastric cancer 4 | 436
pilocytic astrocytoma 4 | 3,086
primary pancreatic ductal adenocarcinoma 4 | 1,271
tuberculosis 4 | 1,563
aldosterone-producing adenoma 3 | 664
nephrosclerosis 3 | 329
spina bifida 3 | 1,064
urothelial carcinoma 3 | 318

Tissue

Blood and immune system 45 | 17,994
Cardiovascular System 45 | 17,957
Digestive Tract 45 | 18,472
Endocrine System 45 | 18,511
Female tissues 45 | 18,646
Liver and Pancreas 45 | 18,135
Male tissues 45 | 17,968
Nervous System 45 | 18,560
Skin and soft tissues 45 | 18,114
Urinary Tract 45 | 18,443
Respiratory system 43 | 17,483

Target Family

Non-IDG 18 | 11,969
Transcription Factor 14 | 1,400
Enzyme 6 | 4,146
Epigenetic 3 | 242
Nuclear Receptor 3 | 48
TF/Epigenetic 1 | 38

PathwayCommons: pid Pathway

FOXA1 transcription factor net... 45 | 45
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.74239 5756.8 1322
Alpha-1-antitrypsin SERPINA1 Tbio Non-IDG -3.73976 5495.0 809
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.12726 13094.7 961
Vitronectin VTN Tbio Transcription Factor -3.30080 1859.4 627
C4b-binding protein beta chain C4BPB Tbio Non-IDG -0.92783 8.66 151
Androgen receptor AR Tclin Nuclear Receptor -3.79989 6683.7 1366
Superoxide dismutase [Cu-Zn] SOD1 Tbio Enzyme -3.27053 1849.3 946
Transcription factor Sp1 SP1 Tchem Transcription Factor -2.99306 923.1 729
Uteroglobin SCGB1A1 Tbio Non-IDG -2.89224 785.2 213
PR domain zinc finger protein 15 PRDM15 Tdark TF/Epigenetic -0.32440 2.27 63