Development Level

Tchem 18 | 1,890
Tbio 11 | 10,625
Tclin 5 | 602

IMPC Phenotype

decreased body weight 2 | 174
decreased lean body mass 2 | 195
abnormal bone mineralization 1 | 55
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal skin condition 1 | 6
decreased B cell number 1 | 30
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased thermal nociceptive ... 1 | 4
enlarged lymph nodes 1 | 27
increased CD4-positive, alpha ... 1 | 15
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased thermal nociceptive ... 1 | 9
preweaning lethality, incomple... 1 | 260

Disease

Cancer 27 | 2,346
osteosarcoma 24 | 7,933
ovarian cancer 22 | 8,491
lung cancer 17 | 4,473
medulloblastoma, large-cell 17 | 6,234
glioblastoma 16 | 5,572
psoriasis 13 | 6,685
Breast cancer 12 | 3,098
atypical teratoid / rhabdoid tumor 12 | 4,369
group 4 medulloblastoma 12 | 1,875
Carcinoma 11 | 2,147
invasive ductal carcinoma 9 | 2,950
primary Sjogren syndrome 9 | 788
subependymal giant cell astrocytoma 9 | 2,287
Rheumatoid Arthritis 8 | 1,170
diabetes mellitus 8 | 1,663
interstitial cystitis 8 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
juvenile dermatomyositis 8 | 1,189
lung carcinoma 8 | 2,844
non-small cell lung cancer 8 | 2,798
pediatric high grade glioma 8 | 2,712
tuberculosis 8 | 1,563
ulcerative colitis 8 | 2,087
Multiple myeloma 7 | 1,327
Anemia 6 | 252
colon cancer 6 | 1,475
cutaneous lupus erythematosus 6 | 1,056
cystic fibrosis 6 | 1,670
ductal carcinoma in situ 6 | 1,745
ependymoma 6 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
lung adenocarcinoma 6 | 2,714
malignant mesothelioma 6 | 3,163
pancreatic cancer 6 | 2,300
pituitary cancer 6 | 1,972
Alzheimer's disease 5 | 644
Arthritis 5 | 248
Liver carcinoma 5 | 217
Vascular disease 5 | 281
astrocytoma 5 | 1,493
breast carcinoma 5 | 1,614
dermatomyositis 5 | 966
gastric carcinoma 5 | 832
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
oligodendroglioma 5 | 2,849
pilocytic astrocytoma 5 | 3,086
spina bifida 5 | 1,064
Asthma 4 | 349
Cryptorchidism 4 | 67
Diabetes Mellitus, Non-Insulin-Dependent 4 | 161
Gaucher disease type 1 4 | 171
Hepatitis C 4 | 90
Immune system cancer 4 | 38
Lung Neoplasms 4 | 171
Mammary Neoplasms 4 | 410
Mastocytosis 4 | 27
Myocardial Infarction 4 | 126
Myocardial Ischemia 4 | 169
Neoplastic Cell Transformation 4 | 81
Noonan Syndrome 4 | 33
Obesity 4 | 616
Pick disease 4 | 1,893
Polycythemia Vera 4 | 24
Primary polycythemia 4 | 7
Stomach Neoplasms 4 | 282
adult high grade glioma 4 | 2,148
astrocytic glioma 4 | 2,241
pancreatic carcinoma 4 | 567
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
progressive supranuclear palsy 4 | 674
Adenocarcinoma 3 | 115
Adenoma 3 | 165
Animal Mammary Neoplasms 3 | 135
Atopic dermatitis 3 | 944
Brain disease 3 | 84
Calcinosis 3 | 63
Crohn's disease 3 | 304
Disease Progression 3 | 125
Heart disease 3 | 279
Inflammatory bowel disease 3 | 142
Juvenile Myelomonocytic Leukemia 3 | 21
Kidney disease 3 | 397
Liver diseases 3 | 66
Lung disease 3 | 136
Mammary Neoplasms, Experimental 3 | 149
Metabolic syndrome X 3 | 155
Multiple Sclerosis 3 | 498
Neoplasm Invasiveness 3 | 127
Nerve Degeneration 3 | 73
Parkinson's disease 3 | 364
Polycystic Ovary Syndrome 3 | 334
Polycythemia 3 | 19
Reperfusion Injury 3 | 84
Waldenstrons macroglobulinemia 3 | 764
active Crohn's disease 3 | 918
medulloblastoma 3 | 1,524
primary pancreatic ductal adenocarcinoma 3 | 1,271
sarcoidosis 3 | 368
urothelial carcinoma 3 | 318

Tissue

Blood and immune system 33 | 17,994
Cardiovascular System 33 | 17,957
Digestive Tract 33 | 18,472
Endocrine System 33 | 18,511
Female tissues 33 | 18,646
Liver and Pancreas 33 | 18,135
Male tissues 33 | 17,968
Nervous System 33 | 18,560
Respiratory system 33 | 17,483
Skin and soft tissues 33 | 18,114
Urinary Tract 33 | 18,443

Target Family

Non-IDG 15 | 11,969
Enzyme 8 | 4,146
Kinase 7 | 634
Transcription Factor 4 | 1,400

PathwayCommons: pid Pathway

EPO signaling pathway 34 | 34
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.39396 233.2 634
Putative short transient receptor potential channel 2-like protein N/A Tchem Non-IDG 0.00000 1
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.78476 58.3 173
GTPase HRas HRAS Tchem Enzyme -3.99319 9497.9 312
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.36614 248.3 109
Signal transducer and activator of transcription 1-alpha/beta STAT1 Tchem Transcription Factor -3.29893 1889.3 1357
Signal transducer and activator of transcription 5A STAT5A Tchem Transcription Factor -3.00212 913.0 1086
Tyrosine-protein kinase Lyn LYN Tclin Kinase -2.82112 659.3 521
Bcl-2-like protein 1 BCL2L1 Tchem Non-IDG -3.63084 3877.0 1177
Apoptosis regulator Bcl-2 BCL2 Tclin Non-IDG -2.16712 123.8 1935