Development Level

Tchem 20 | 1,890
Tbio 17 | 10,625
Tclin 3 | 602

IMPC Term

abnormal behavior 3 | 226
abnormal bone structure 3 | 131
decreased bone mineral content 2 | 157
decreased lean body mass 2 | 195
irregularly shaped pupil 2 | 7
preweaning lethality, complete... 2 | 633
abnormal cornea morphology 1 | 24
abnormal femur morphology 1 | 14
abnormal iris morphology 1 | 12
abnormal retina morphology 1 | 100
corneal opacity 1 | 25
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating glucose ... 1 | 121
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased rib number 1 | 59
decreased total body fat amoun... 1 | 186
decreased vertical activity 1 | 22
enlarged adrenal glands 1 | 3
enlarged kidney 1 | 7
enlarged uterus 1 | 3
female infertility 1 | 34
hydrometra 1 | 13
hydrops fetalis 1 | 22
hypoactivity 1 | 89
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased fasted circulating g... 1 | 68
increased lean body mass 1 | 107
male infertility 1 | 62
persistence of hyaloid vascula... 1 | 22
polycystic kidney 1 | 9
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
tremors 1 | 34

Disease

Cancer 28 | 2,346
ovarian cancer 26 | 8,484
osteosarcoma 21 | 7,933
psoriasis 21 | 6,685
atypical teratoid / rhabdoid tumor 19 | 4,369
glioblastoma 19 | 5,572
medulloblastoma, large-cell 19 | 6,234
oligodendroglioma 17 | 2,849
Carcinoma 16 | 2,147
Pick disease 16 | 1,893
Breast cancer 15 | 3,094
lung cancer 15 | 4,466
pediatric high grade glioma 15 | 2,712
primitive neuroectodermal tumor 13 | 3,031
astrocytic glioma 11 | 2,241
ependymoma 10 | 2,514
invasive ductal carcinoma 10 | 2,950
lung adenocarcinoma 10 | 2,713
pancreatic cancer 10 | 2,300
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
lung carcinoma 9 | 2,844
pilocytic astrocytoma 9 | 3,086
subependymal giant cell astrocytoma 9 | 2,287
Parkinson's disease 8 | 364
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
juvenile dermatomyositis 8 | 1,189
malignant mesothelioma 8 | 3,162
medulloblastoma 8 | 1,524
non-small cell lung cancer 8 | 2,798
Mammary Neoplasms 7 | 410
astrocytoma 7 | 1,493
breast carcinoma 7 | 1,614
cystic fibrosis 7 | 1,665
ductal carcinoma in situ 7 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
primary pancreatic ductal adenocarcinoma 7 | 1,271
Blastic phase chronic myeloid leukemia 6 | 58
Chronic Myelocytic Leukemia Accelerated Phase 6 | 59
Lung Neoplasms 6 | 171
Neoplasm Invasiveness 6 | 127
Noonan Syndrome 6 | 33
Squamous cell carcinoma 6 | 94
diabetes mellitus 6 | 1,663
group 4 medulloblastoma 6 | 1,875
pituitary cancer 6 | 1,972
sonic hedgehog group medulloblastoma 6 | 1,482
Animal Mammary Neoplasms 5 | 136
Chronic phase chronic myeloid leukemia 5 | 45
Intellectual disability 5 | 573
Liver carcinoma 5 | 217
Mammary Neoplasms, Experimental 5 | 150
Multiple myeloma 5 | 1,327
Neoplasm Metastasis 5 | 138
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 5 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 5 | 47
Rheumatoid Arthritis 5 | 1,160
Stomach Neoplasms 5 | 282
Vascular disease 5 | 281
interstitial cystitis 5 | 2,299
non-small cell lung carcinoma 5 | 413
spina bifida 5 | 1,064
Adenocarcinoma of lung (disorder) 4 | 48
Arthritis 4 | 248
Cardiofaciocutaneous syndrome 4 | 15
Down syndrome 4 | 548
IGA Glomerulonephritis 4 | 454
Kidney cancer 4 | 118
Prostatic Neoplasms 4 | 471
Renal Cell Carcinoma 4 | 199
group 3 medulloblastoma 4 | 2,254
ovarian neoplasm 4 | 97
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
posterior fossa group A ependymoma 4 | 1,511
tuberculosis 4 | 1,557
tuberculosis and treatment for 6 months 4 | 686
Adenocarcinoma 3 | 115
Adenoma 3 | 165
Alzheimer's disease 3 | 644
Amyotrophic Lateral Sclerosis 3 | 431
Autistic Disorder 3 | 320
Bladder Neoplasm 3 | 109
Brain Ischemia 3 | 87
Chronic Lymphocytic Leukemia 3 | 242
Colorectal Neoplasms 3 | 217
Exanthem 3 | 39
Heart disease 3 | 279
Juvenile Myelomonocytic Leukemia 3 | 21
Kidney disease 3 | 396
Liver neoplasms 3 | 109
Melanoma 3 | 261
Neuroblastoma 3 | 78
Schizophrenia 3 | 501
adult high grade glioma 3 | 2,148
colon cancer 3 | 1,475
cutaneous lupus erythematosus 3 | 1,056
dermatomyositis 3 | 933
esophageal adenocarcinoma 3 | 737
glioblastoma multiforme 3 | 347
mucosa-associated lymphoid tissue lymphoma 3 | 480
nephrosclerosis 3 | 329

Tissue

Blood and immune system 40 | 17,995
Cardiovascular System 40 | 17,958
Digestive Tract 40 | 18,473
Endocrine System 40 | 18,512
Female tissues 40 | 18,647
Liver and Pancreas 40 | 18,136
Male tissues 40 | 17,969
Nervous System 40 | 18,561
Respiratory system 40 | 17,484
Skin and soft tissues 40 | 18,115
Urinary Tract 40 | 18,444

Target Family

Non-IDG 16 | 11,971
Kinase 15 | 634
Enzyme 9 | 4,146

PathwayCommons: pid Pathway

EPHB forward signaling 40 | 40
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Serotransferrin TF Tchem Non-IDG -4.13136 13124.3 952
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424
Ras-related protein Rap-1A RAP1A Tchem Enzyme -2.40521 288.3 256
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.59731 397.5 89
Synaptojanin-1 SYNJ1 Tbio Non-IDG -1.73737 58.0 91
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.60410 3186.8 1232
Ephrin-A5 EFNA5 Tbio Non-IDG -2.51804 342.1 190
Ephrin-B1 EFNB1 Tbio Non-IDG -2.22021 187.7 305