Development Level

Tchem 9 | 1,890
Tbio 8 | 10,625
Tclin 2 | 602

IMPC Term

abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal femur morphology 1 | 14
abnormal vocalization 1 | 21
decreased bone mineral content 1 | 157
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
increased blood urea nitrogen ... 1 | 44
increased sacral vertebrae num... 1 | 62
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 17 | 8,484
Cancer 14 | 2,346
osteosarcoma 13 | 7,933
Carcinoma 9 | 2,147
medulloblastoma, large-cell 8 | 6,234
psoriasis 8 | 6,685
atypical teratoid / rhabdoid tumor 7 | 4,369
glioblastoma 7 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
lung cancer 6 | 4,466
lung carcinoma 6 | 2,844
pancreatic cancer 6 | 2,300
Breast cancer 5 | 3,094
Pick disease 5 | 1,893
Rheumatoid Arthritis 5 | 1,160
diabetes mellitus 5 | 1,663
group 4 medulloblastoma 5 | 1,875
invasive ductal carcinoma 5 | 2,950
juvenile dermatomyositis 5 | 1,189
pituitary cancer 5 | 1,972
primitive neuroectodermal tumor 5 | 3,031
subependymal giant cell astrocytoma 5 | 2,287
ulcerative colitis 5 | 2,087
Mammary Neoplasms 4 | 410
Multiple myeloma 4 | 1,327
Neoplasm Invasiveness 4 | 127
ductal carcinoma in situ 4 | 1,745
ependymoma 4 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
malignant mesothelioma 4 | 3,162
non-small cell lung cancer 4 | 2,798
oligodendroglioma 4 | 2,849
pediatric high grade glioma 4 | 2,712
IGA Glomerulonephritis 3 | 454
Liver carcinoma 3 | 217
Waldenstrons macroglobulinemia 3 | 765
breast carcinoma 3 | 1,614
cystic fibrosis 3 | 1,665
group 3 medulloblastoma 3 | 2,254
interstitial cystitis 3 | 2,299
medulloblastoma 3 | 1,524
spina bifida 3 | 1,064
tuberculosis 3 | 1,557
AMYOTROPHIC LATERAL SCLEROSIS 1 2 | 49
Asthma 2 | 349
Bladder Neoplasm 2 | 109
Blastic phase chronic myeloid leukemia 2 | 58
Cardiomegaly 2 | 66
Chronic Myelocytic Leukemia Accelerated Phase 2 | 59
Chronic phase chronic myeloid leukemia 2 | 45
Down syndrome 2 | 548
Endometrial cancer 2 | 25
Growth Disorders 2 | 33
Kidney cancer 2 | 118
Kidney disease 2 | 396
Noonan Syndrome 2 | 33
Parkinson's disease 2 | 364
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 2 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 2 | 47
Prostatic Neoplasms 2 | 471
Proteinuria 2 | 63
Renal Cell Carcinoma 2 | 199
Squamous cell carcinoma 2 | 94
Stomach Neoplasms 2 | 282
adult high grade glioma 2 | 2,148
astrocytic glioma 2 | 2,241
astrocytoma 2 | 1,493
colon cancer 2 | 1,475
mucosa-associated lymphoid tissue lymphoma 2 | 480
nasopharyngeal carcinoma 2 | 1,056
non primary Sjogren syndrome sicca 2 | 840
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
pilocytic astrocytoma 2 | 3,086
primary Sjogren syndrome 2 | 789
primary pancreatic ductal adenocarcinoma 2 | 1,271
Anemia 1 | 252
Animal Mammary Neoplasms 1 | 136
COPD 1 | 113
Colorectal Cancer 1 | 47
Colorectal Neoplasms 1 | 217
Gaucher disease type 1 1 | 171
Head and neck squamous cell carcinoma 1 | 12
Hematologic cancer 1 | 9
Hirschsprung's disease 1 | 42
Homocystinuria 1 | 23
Immune system cancer 1 | 38
Impotence 1 | 45
Liver diseases 1 | 66
Lung Neoplasms 1 | 171
Mammary Neoplasms, Experimental 1 | 150
Melanoma 1 | 261
Muscle Weakness 1 | 92
Neoplasm Metastasis 1 | 138
Pulmonary Embolism 1 | 45
Seborrheic keratosis 1 | 6
Vitamin B12 deficiency 1 | 20
Weight Gain 1 | 87
sarcoidosis 1 | 358

Tissue

Blood and immune system 19 | 17,995
Cardiovascular System 19 | 17,958
Digestive Tract 19 | 18,473
Endocrine System 19 | 18,512
Female tissues 19 | 18,647
Liver and Pancreas 19 | 18,136
Male tissues 19 | 17,969
Nervous System 19 | 18,561
Respiratory system 19 | 17,484
Skin and soft tissues 19 | 18,115
Urinary Tract 19 | 18,444

Target Family

Kinase 7 | 634
Enzyme 6 | 4,146
Non-IDG 6 | 11,971

PathwayCommons: pid Pathway

EPHA2 forward signaling 19 | 19
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Low molecular weight phosphotyrosine protein phosphatase ACP1 Tchem Enzyme -2.42254 282.0 209
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424
Transforming protein RhoA RHOA Tbio Enzyme -3.48838 3096.5 467
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.76038 58.3 173
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.83396 73.5 395
Guanine nucleotide exchange factor VAV3 VAV3 Tbio Non-IDG -1.76403 69.0 206
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 INPPL1 Tchem Enzyme -2.01260 134.9 212
E3 ubiquitin-protein ligase CBL CBL Tbio Enzyme -2.89085 850.0 753
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.01237 956.9 1799