Development Level

Tbio 26 | 10,625
Tchem 13 | 1,890
Tclin 8 | 602
Tdark 1 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

male infertility 3 | 62
abnormal embryo size 2 | 112
embryonic lethality prior to t... 2 | 187
female infertility 2 | 34
preweaning lethality, complete... 2 | 633
preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal eye morphology 1 | 38
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal optic disc morphology 1 | 10
abnormal spinal cord morpholog... 1 | 8
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
absent seminal vesicle 1 | 2
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased lean body mass 1 | 195
decreased macrophage cell numb... 1 | 4
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased total body fat amoun... 1 | 186
hydrops fetalis 1 | 22
increased circulating calcium ... 1 | 32
increased circulating phosphat... 1 | 24
increased circulating total pr... 1 | 20
increased circulating triglyce... 1 | 24
increased heart weight 1 | 37
increased mean corpuscular vol... 1 | 91
increased startle reflex 1 | 38
microphthalmia 1 | 15
short tibia 1 | 82
small testis 1 | 37
tremors 1 | 34

Disease

Cancer 34 | 2,346
psoriasis 30 | 6,685
ovarian cancer 25 | 8,484
lung cancer 21 | 4,466
Rheumatoid Arthritis 20 | 1,160
glioblastoma 19 | 5,572
osteosarcoma 19 | 7,933
diabetes mellitus 18 | 1,663
ulcerative colitis 18 | 2,087
Multiple Sclerosis 17 | 498
interstitial cystitis 17 | 2,299
medulloblastoma, large-cell 17 | 6,234
non-small cell lung cancer 16 | 2,798
Asthma 15 | 349
Hypersensitivity reaction type II disease 15 | 235
Arthritis 14 | 248
pancreatic cancer 14 | 2,300
tuberculosis 14 | 1,557
Allergic hypersensitivity disease 13 | 123
Dermatitis 13 | 107
Kidney disease 13 | 396
Lung disease 13 | 132
lung adenocarcinoma 13 | 2,713
lung carcinoma 13 | 2,844
malignant mesothelioma 13 | 3,162
Allergic rhinitis 12 | 91
Eosinophilia 12 | 65
astrocytoma 12 | 1,493
pituitary cancer 12 | 1,972
primitive neuroectodermal tumor 12 | 3,031
Breast cancer 11 | 3,094
Inflammatory bowel disease 11 | 142
atypical teratoid / rhabdoid tumor 11 | 4,369
cutaneous lupus erythematosus 11 | 1,056
oligodendroglioma 11 | 2,849
Atherosclerosis 10 | 275
Melanoma 10 | 261
colon cancer 10 | 1,475
hepatocellular carcinoma 10 | 532
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,956
Cerebrovascular disease 9 | 231
Crohn's disease 9 | 304
Heart disease 9 | 279
Inflammation 9 | 109
Liver disease 9 | 219
Mammary Neoplasms 9 | 410
breast carcinoma 9 | 1,614
group 4 medulloblastoma 9 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
periodontitis 9 | 269
Alzheimer's disease 8 | 644
Diarrhea 8 | 155
Hepatitis B 8 | 103
Hypertension 8 | 287
Influenza 8 | 142
Leishmaniasis 8 | 49
Malaria 8 | 140
Reperfusion Injury 8 | 84
Schizophrenia 8 | 501
Tetanus 8 | 66
acute myeloid leukemia 8 | 780
ependymoma 8 | 2,514
esophageal adenocarcinoma 8 | 737
pilocytic astrocytoma 8 | 3,086
Acquired immunodeficiency syndrome 7 | 164
Adult T-Cell Lymphoma/Leukemia 7 | 30
Anemia 7 | 252
Dermatitis, Allergic Contact 7 | 66
Leukopenia 7 | 42
Lung Neoplasms 7 | 171
Neuropathy 7 | 210
Obesity 7 | 616
Peripheral Neuropathy 7 | 303
Uveitis 7 | 103
Vasculitis 7 | 64
adrenocortical carcinoma 7 | 1,427
astrocytic glioma 7 | 2,241
invasive ductal carcinoma 7 | 2,950
sarcoidosis 7 | 358
subependymal giant cell astrocytoma 7 | 2,287
Aspergillosis 6 | 23
Autistic Disorder 6 | 320
Colitis 6 | 46
Coronary artery disease 6 | 240
Diabetes Mellitus, Insulin-Dependent 6 | 76
Gastritis 6 | 44
Glomerulonephritis 6 | 36
Hyperglycemia 6 | 120
Leprosy 6 | 77
Liver carcinoma 6 | 217
Parkinson's disease 6 | 364
Prostatic Neoplasms 6 | 471
Status Epilepticus 6 | 85
Stomach Neoplasms 6 | 282
Toxic encephalopathy 6 | 131
Vascular disease 6 | 281
cystic fibrosis 6 | 1,665
fibroadenoma 6 | 557
nephrosclerosis 6 | 329

Tissue

Digestive Tract 47 | 18,473
Endocrine System 47 | 18,512
Female tissues 47 | 18,647
Nervous System 47 | 18,561
Urinary Tract 47 | 18,444
Blood and immune system 46 | 17,995
Cardiovascular System 46 | 17,958
Liver and Pancreas 46 | 18,136
Respiratory system 46 | 17,484
Skin and soft tissues 46 | 18,115
Male tissues 45 | 17,969

Target Family

Transcription Factor 21 | 1,400
Non-IDG 15 | 11,971
Enzyme 7 | 4,146
Kinase 3 | 634
Nuclear Receptor 1 | 48
Transporter 1 | 473

PathwayCommons: pid Pathway

Calcineurin-regulated NFAT-dep... 48 | 48
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Forkhead box protein P3 FOXP3 Tbio Transcription Factor -3.60057 5680.3 1162
Prostaglandin G/H synthase 2 PTGS2 Tclin Enzyme -4.03668 12041.6 648
Guanylate-binding protein 3 GBP3 Tbio Non-IDG -0.81808 5.65 111
Interleukin-2 receptor subunit alpha IL2RA Tclin Non-IDG -2.98987 913.0 1297
Interferon gamma IFNG Tbio Non-IDG -3.87939 5432.4 1711
POU domain, class 2, transcription factor 1 POU2F1 Tchem Transcription Factor -2.13126 135.4 444
Peroxisome proliferator-activated receptor gamma PPARG Tclin Nuclear Receptor -3.91275 8950.6 711
Tumor necrosis factor ligand superfamily member 6 FASLG Tchem Non-IDG -3.48531 3494.0 818
Nuclear factor of activated T-cells, cytoplasmic 3 NFATC3 Tbio Transcription Factor -1.99681 101.3 183