Development Level

Tbio 43 | 10,625
Tchem 32 | 1,890
Tclin 12 | 602

IMPC Term

preweaning lethality, complete... 6 | 633
abnormal behavior 4 | 226
decreased bone mineral content 4 | 157
decreased lean body mass 3 | 195
abnormal bone structure 2 | 131
abnormal coping response 2 | 12
abnormal embryo size 2 | 112
abnormal spleen morphology 2 | 36
decreased blood urea nitrogen ... 2 | 31
decreased fasted circulating g... 2 | 49
decreased heart weight 2 | 44
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
decreased total body fat amoun... 2 | 186
enlarged spleen 2 | 26
increased blood urea nitrogen ... 2 | 44
increased circulating alkaline... 2 | 119
increased circulating phosphat... 2 | 24
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular hem... 2 | 93
abnormal body wall morphology 1 | 7
abnormal femur morphology 1 | 14
abnormal seminal vesicle morph... 1 | 47
abnormal skin morphology 1 | 23
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased grip strength 1 | 123
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased respiratory quotient 1 | 12
decreased startle reflex 1 | 48
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
embryonic lethality prior to t... 1 | 187
enlarged lymph nodes 1 | 27
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
improved glucose tolerance 1 | 56
increased cardiac stroke volum... 1 | 1
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating calcium ... 1 | 32
increased circulating creatini... 1 | 29
increased circulating iron lev... 1 | 25
increased circulating potassiu... 1 | 31
increased circulating total pr... 1 | 20
increased grip strength 1 | 83
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
male infertility 1 | 62
prenatal lethality prior to he... 1 | 64
protruding tongue 1 | 1
short tibia 1 | 82
small testis 1 | 37
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

osteosarcoma 65 | 7,933
ovarian cancer 53 | 8,484
Cancer 48 | 2,346
psoriasis 42 | 6,685
medulloblastoma, large-cell 40 | 6,234
glioblastoma 39 | 5,572
lung cancer 32 | 4,466
lung carcinoma 30 | 2,844
invasive ductal carcinoma 28 | 2,950
subependymal giant cell astrocytoma 27 | 2,287
atypical teratoid / rhabdoid tumor 26 | 4,369
Breast cancer 23 | 3,094
Rheumatoid Arthritis 23 | 1,160
interstitial cystitis 22 | 2,299
oligodendroglioma 22 | 2,849
pilocytic astrocytoma 22 | 3,086
astrocytoma 21 | 1,493
diabetes mellitus 21 | 1,663
cutaneous lupus erythematosus 19 | 1,056
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,289
non-small cell lung cancer 19 | 2,798
primary Sjogren syndrome 19 | 789
group 4 medulloblastoma 18 | 1,875
malignant mesothelioma 18 | 3,162
ulcerative colitis 18 | 2,087
Pick disease 17 | 1,893
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,988
juvenile dermatomyositis 17 | 1,189
pancreatic cancer 17 | 2,300
pediatric high grade glioma 17 | 2,712
adult high grade glioma 16 | 2,148
Carcinoma 15 | 2,147
breast carcinoma 15 | 1,614
ductal carcinoma in situ 15 | 1,745
ependymoma 15 | 2,514
primitive neuroectodermal tumor 15 | 3,031
Multiple myeloma 14 | 1,327
cystic fibrosis 14 | 1,665
lung adenocarcinoma 14 | 2,713
Waldenstrons macroglobulinemia 13 | 765
astrocytic glioma 13 | 2,241
dermatomyositis 13 | 933
tuberculosis 13 | 1,557
medulloblastoma 12 | 1,524
Schizophrenia 11 | 501
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
primary pancreatic ductal adenocarcinoma 11 | 1,271
Alzheimer's disease 10 | 644
Mammary Neoplasms 10 | 410
Multiple Sclerosis 10 | 498
colon cancer 10 | 1,475
group 3 medulloblastoma 10 | 2,254
posterior fossa group A ependymoma 10 | 1,511
Arthritis 9 | 248
Blastic phase chronic myeloid leukemia 9 | 58
Chronic Myelocytic Leukemia Accelerated Phase 9 | 59
Vascular disease 9 | 281
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
pituitary cancer 9 | 1,972
IGA Glomerulonephritis 8 | 454
Kidney disease 8 | 396
Obesity 8 | 616
Prostatic Neoplasms 8 | 471
acute quadriplegic myopathy 8 | 1,157
esophageal adenocarcinoma 8 | 737
Chronic phase chronic myeloid leukemia 7 | 45
Down syndrome 7 | 548
Duchenne muscular dystrophy 7 | 602
Hypersensitivity reaction type II disease 7 | 235
Liver carcinoma 7 | 217
Lung disease 7 | 132
Neoplasm Invasiveness 7 | 127
Neoplasm Metastasis 7 | 138
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 7 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 7 | 47
active Crohn's disease 7 | 918
mucosa-associated lymphoid tissue lymphoma 7 | 480
posterior fossa group B ependymoma 7 | 1,530
sarcoidosis 7 | 358
Asthma 6 | 349
Atopic dermatitis 6 | 944
Heart disease 6 | 279
Mammary Neoplasms, Experimental 6 | 150
Squamous cell carcinoma 6 | 94
gastric carcinoma 6 | 832
pancreatic carcinoma 6 | 567
periodontitis 6 | 269
spina bifida 6 | 1,064
Anemia 5 | 252
Cerebrovascular disease 5 | 231
Chronic Lymphocytic Leukemia 5 | 242
Epilepsy 5 | 346
Inflammatory bowel disease 5 | 142
Severe Combined Immunodeficiency 5 | 46
active ulcerative colitis 5 | 477
adrenocortical carcinoma 5 | 1,427
head and neck cancer and chronic obstructive pulmonary disease 5 | 237
non-small cell lung carcinoma 5 | 413
sonic hedgehog group medulloblastoma 5 | 1,482
tuberculosis and treatment for 6 months 5 | 686

Tissue

Blood and immune system 85 | 17,995
Cardiovascular System 85 | 17,958
Digestive Tract 85 | 18,473
Female tissues 85 | 18,647
Male tissues 85 | 17,969
Nervous System 85 | 18,561
Respiratory system 85 | 17,484
Urinary Tract 85 | 18,444
Endocrine System 84 | 18,512
Liver and Pancreas 84 | 18,136
Skin and soft tissues 83 | 18,115

Target Family

Non-IDG 36 | 11,971
Kinase 24 | 634
Enzyme 20 | 4,146
Transcription Factor 6 | 1,400
GPCR 1 | 406

PathwayCommons: pid Pathway

CXCR4-mediated signaling event... 87 | 87
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.90528 8199.7 1129
Protein phosphatase Slingshot homolog 1 SSH1 Tbio Enzyme -1.41770 25.0 106
Ras-related protein Ral-B RALB Tbio Enzyme -1.69182 49.7 204
HLA class II histocompatibility antigen, DR alpha chain HLA-DRA Tbio Non-IDG -2.11580 125.1 660
Transforming protein RhoA RHOA Tbio Enzyme -3.48838 3096.5 467
Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Tchem Enzyme -3.06784 1308.8 971
T-cell receptor alpha chain C region TRAC Tbio Non-IDG 0.00000 0
3-phosphoinositide-dependent protein kinase 1 PDPK1 Tchem Kinase -2.24871 191.5 579
T-cell receptor beta-1 chain C region TRBC1 Tbio Non-IDG 0.00000 0