Development Level

Tbio 33 | 10,625
Tchem 32 | 1,890
Tclin 6 | 602

Collection

Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 633
decreased circulating fructosa... 3 | 31
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal bone structure 2 | 131
abnormal startle reflex 2 | 14
decreased blood urea nitrogen ... 2 | 31
decreased bone mineral content 2 | 157
decreased lean body mass 2 | 195
decreased total body fat amoun... 2 | 186
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased mean corpuscular hem... 2 | 93
abnormal bone mineralization 1 | 55
abnormal coat-hair pigmentatio... 1 | 54
abnormal craniofacial morpholo... 1 | 12
abnormal digestive system phys... 1 | 1
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal femur morphology 1 | 14
abnormal hair texture 1 | 4
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal pericardium morpholog... 1 | 11
abnormal posture 1 | 5
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
cataract 1 | 26
decreased body weight 1 | 174
decreased circulating LDL chol... 1 | 37
decreased circulating creatini... 1 | 31
decreased circulating free fat... 1 | 39
decreased circulating insulin ... 1 | 75
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased fasted circulating g... 1 | 49
decreased leukocyte cell numbe... 1 | 54
decreased mean corpuscular vol... 1 | 50
embryonic growth retardation 1 | 28
embryonic lethality prior to t... 1 | 187
enlarged lymph nodes 1 | 27
fusion of vertebral arches 1 | 7
increased CD8-positive, naive ... 1 | 3
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased circulating LDL chol... 1 | 15
increased circulating alanine ... 1 | 11
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating iron lev... 1 | 25
increased erythrocyte cell num... 1 | 26
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased red blood cell distr... 1 | 21
increased total body fat amoun... 1 | 57
increased vertical activity 1 | 18
long tibia 1 | 13
pallor 1 | 13
vertebral fusion 1 | 23

Disease

ovarian cancer 53 | 8,491
medulloblastoma, large-cell 47 | 6,234
osteosarcoma 47 | 7,933
glioblastoma 44 | 5,572
Cancer 40 | 2,346
atypical teratoid / rhabdoid tumor 38 | 4,369
psoriasis 38 | 6,685
Breast cancer 28 | 3,098
pilocytic astrocytoma 28 | 3,086
lung cancer 25 | 4,473
oligodendroglioma 24 | 2,849
primitive neuroectodermal tumor 24 | 3,031
pediatric high grade glioma 23 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,988
Carcinoma 21 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,956
diabetes mellitus 19 | 1,663
ependymoma 19 | 2,514
group 4 medulloblastoma 19 | 1,875
pancreatic cancer 18 | 2,300
subependymal giant cell astrocytoma 18 | 2,287
malignant mesothelioma 17 | 3,163
Pick disease 16 | 1,893
non-small cell lung cancer 16 | 2,798
invasive ductal carcinoma 15 | 2,950
juvenile dermatomyositis 15 | 1,189
medulloblastoma 15 | 1,524
astrocytic glioma 14 | 2,241
astrocytoma 14 | 1,493
adult high grade glioma 13 | 2,148
Mammary Neoplasms 12 | 410
Vascular disease 12 | 281
breast carcinoma 12 | 1,614
primary pancreatic ductal adenocarcinoma 12 | 1,271
tuberculosis 12 | 1,563
Lung Neoplasms 11 | 171
Waldenstrons macroglobulinemia 11 | 764
ductal carcinoma in situ 11 | 1,745
lung adenocarcinoma 11 | 2,714
pituitary cancer 11 | 1,972
Alzheimer's disease 10 | 644
Neoplasm Invasiveness 10 | 127
Rheumatoid Arthritis 10 | 1,170
Stomach Neoplasms 10 | 282
cystic fibrosis 10 | 1,670
group 3 medulloblastoma 10 | 2,254
posterior fossa group A ependymoma 10 | 1,511
Intellectual disability 9 | 573
Parkinson's disease 9 | 364
posterior fossa group B ependymoma 9 | 1,530
Kidney disease 8 | 397
Liver carcinoma 8 | 217
Liver neoplasms 8 | 108
acute quadriplegic myopathy 8 | 1,157
colon cancer 8 | 1,475
dermatomyositis 8 | 966
spina bifida 8 | 1,064
Multiple myeloma 7 | 1,327
Neoplasm Metastasis 7 | 138
Precancerous Conditions 7 | 69
Prostatic Neoplasms 7 | 471
Schizophrenia 7 | 503
adrenocortical carcinoma 7 | 1,427
lung carcinoma 7 | 2,844
pancreatic carcinoma 7 | 567
progressive supranuclear palsy 7 | 674
ulcerative colitis 7 | 2,087
Adenoma 6 | 165
Arthritis 6 | 248
Colorectal Neoplasms 6 | 217
IGA Glomerulonephritis 6 | 454
Neoplastic Cell Transformation 6 | 81
Obesity 6 | 616
Renal Cell Carcinoma 6 | 199
esophageal adenocarcinoma 6 | 737
gastric cancer 6 | 436
interstitial cystitis 6 | 2,299
ovarian neoplasm 6 | 97
primary Sjogren syndrome 6 | 788
sonic hedgehog group medulloblastoma 6 | 1,482
Animal Mammary Neoplasms 5 | 135
Autistic Disorder 5 | 320
Carcinoma of colon 5 | 32
Colonic Neoplasms 5 | 126
Down syndrome 5 | 548
Duchenne muscular dystrophy 5 | 602
Endometriosis 5 | 535
Heart disease 5 | 279
Kidney cancer 5 | 121
Lung disease 5 | 136
Mammary Neoplasms, Experimental 5 | 149
Noonan Syndrome 5 | 33
Squamous cell carcinoma 5 | 96
Toxic encephalopathy 5 | 131
acute myeloid leukemia 5 | 785
atypical teratoid/rhabdoid tumor 5 | 1,095
hepatocellular carcinoma 5 | 550
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
non diabetic and post-ischemic heart failure 4 | 200

Tissue

Cardiovascular System 71 | 17,957
Digestive Tract 71 | 18,472
Endocrine System 71 | 18,511
Female tissues 71 | 18,646
Liver and Pancreas 71 | 18,135
Nervous System 71 | 18,560
Respiratory system 71 | 17,483
Skin and soft tissues 71 | 18,114
Urinary Tract 71 | 18,443
Blood and immune system 70 | 17,994
Male tissues 70 | 17,968

Target Family

Kinase 29 | 634
Non-IDG 28 | 11,969
Enzyme 9 | 4,146
Transcription Factor 4 | 1,400
GPCR 1 | 408

PathwayCommons: pid Pathway

CDC42 signaling events 71 | 71
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase B-raf BRAF Tclin Kinase -2.28702 199.1 1276
Ras-specific guanine nucleotide-releasing factor 1 RASGRF1 Tchem Non-IDG -1.94899 92.4 213
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.78476 58.3 173
GTPase HRas HRAS Tchem Enzyme -3.99319 9497.9 312
Transcription factor HES-5 HES5 Tbio Transcription Factor -2.03078 88.8 104
Dual specificity mitogen-activated protein kinase kinase 6 MAP2K6 Tchem Kinase -1.97989 67.5 582
Rho GDP-dissociation inhibitor 1 ARHGDIA Tchem Non-IDG -2.55630 360.5 330
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.87449 73.5 395
RAF proto-oncogene serine/threonine-protein kinase RAF1 Tclin Kinase -3.09190 1147.5 1943
Breast cancer anti-estrogen resistance protein 1 BCAR1 Tbio Non-IDG -2.38651 211.2 490