Development Level

Tchem 23 | 1,890
Tbio 12 | 10,625
Tclin 1 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

decreased circulating sodium l... 2 | 18
preweaning lethality, complete... 2 | 633
abnormal cornea morphology 1 | 24
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal skin condition 1 | 6
abnormal startle reflex 1 | 14
decreased circulating alanine ... 1 | 53
decreased circulating amylase ... 1 | 24
decreased circulating creatini... 1 | 31
decreased circulating fructosa... 1 | 31
decreased fasted circulating g... 1 | 49
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased monocyte cell number 1 | 28
decreased thermal nociceptive ... 1 | 4
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased erythrocyte cell num... 1 | 26
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased thermal nociceptive ... 1 | 9
polydactyly 1 | 22
preweaning lethality, incomple... 1 | 260

Disease

Cancer 27 | 2,346
ovarian cancer 22 | 8,484
glioblastoma 18 | 5,572
psoriasis 18 | 6,685
lung cancer 16 | 4,466
osteosarcoma 15 | 7,933
medulloblastoma, large-cell 14 | 6,234
atypical teratoid / rhabdoid tumor 12 | 4,369
Carcinoma 11 | 2,147
primitive neuroectodermal tumor 11 | 3,031
pilocytic astrocytoma 10 | 3,086
tuberculosis 10 | 1,557
Rheumatoid Arthritis 9 | 1,160
diabetes mellitus 9 | 1,663
medulloblastoma 9 | 1,524
oligodendroglioma 9 | 2,849
subependymal giant cell astrocytoma 9 | 2,287
ulcerative colitis 9 | 2,087
Mammary Neoplasms 8 | 410
Multiple Sclerosis 8 | 498
Vascular disease 8 | 281
lung carcinoma 8 | 2,844
malignant mesothelioma 8 | 3,162
non-small cell lung cancer 8 | 2,798
Arthritis 7 | 248
Lung Neoplasms 7 | 171
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
pediatric high grade glioma 7 | 2,712
Asthma 6 | 349
Breast cancer 6 | 3,094
Inflammatory bowel disease 6 | 142
Kidney disease 6 | 396
Lung disease 6 | 132
Multiple myeloma 6 | 1,327
Neoplastic Cell Transformation 6 | 81
Stomach Neoplasms 6 | 282
acute myeloid leukemia 6 | 780
acute quadriplegic myopathy 6 | 1,157
adult high grade glioma 6 | 2,148
astrocytoma 6 | 1,493
dermatomyositis 6 | 933
interstitial cystitis 6 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,988
invasive ductal carcinoma 6 | 2,950
juvenile dermatomyositis 6 | 1,189
lung adenocarcinoma 6 | 2,713
pancreatic cancer 6 | 2,300
Alzheimer's disease 5 | 644
Brain Ischemia 5 | 87
Liver carcinoma 5 | 217
Pick disease 5 | 1,893
Toxic encephalopathy 5 | 131
cystic fibrosis 5 | 1,665
ependymoma 5 | 2,514
group 4 medulloblastoma 5 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
posterior fossa group A ependymoma 5 | 1,511
Acquired immunodeficiency syndrome 4 | 164
Adenoma 4 | 165
Brain disease 4 | 83
Cardiomyopathies 4 | 90
Colonic Neoplasms 4 | 126
Heart disease 4 | 279
Hypersensitivity reaction type II disease 4 | 235
Parkinson's disease 4 | 364
Prostatic Neoplasms 4 | 471
Reperfusion Injury 4 | 84
Waldenstrons macroglobulinemia 4 | 765
colon cancer 4 | 1,475
ductal carcinoma in situ 4 | 1,745
periodontitis 4 | 269
pituitary cancer 4 | 1,972
primary Sjogren syndrome 4 | 789
Allergic hypersensitivity disease 3 | 123
Atherosclerosis 3 | 275
Atopic dermatitis 3 | 944
Cholestasis 3 | 93
Coronary artery disease 3 | 240
Crohn's disease 3 | 304
Dermatitis 3 | 107
Diabetes Mellitus, Non-Insulin-Dependent 3 | 157
Influenza 3 | 142
Leishmaniasis 3 | 49
Liver neoplasms 3 | 109
Malignant neoplasm of breast 3 | 63
Myocardial Ischemia 3 | 169
Neurodegenerative disease 3 | 383
Osteoporosis 3 | 257
Pancreatic Neoplasm 3 | 79
Schizophrenia 3 | 501
Severe Combined Immunodeficiency 3 | 46
active Crohn's disease 3 | 918
breast carcinoma 3 | 1,614
cutaneous lupus erythematosus 3 | 1,056
esophageal adenocarcinoma 3 | 737
pancreatic carcinoma 3 | 567
sonic hedgehog group medulloblastoma 3 | 1,482
spina bifida 3 | 1,064
tuberculosis and treatment for 6 months 3 | 686

Tissue

Blood and immune system 36 | 17,995
Digestive Tract 36 | 18,473
Female tissues 36 | 18,647
Male tissues 36 | 17,969
Nervous System 36 | 18,561
Respiratory system 36 | 17,484
Urinary Tract 36 | 18,444
Cardiovascular System 35 | 17,958
Endocrine System 35 | 18,512
Liver and Pancreas 35 | 18,136
Skin and soft tissues 35 | 18,115

Target Family

Kinase 14 | 634
Non-IDG 14 | 11,971
Transcription Factor 5 | 1,400
Enzyme 3 | 4,146

PathwayCommons: pid Pathway

CD40/CD40L signaling 36 | 36
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
NF-kappa-B inhibitor alpha NFKBIA Tchem Non-IDG -3.34160 1960.9 1181
Tumor necrosis factor receptor superfamily member 5 CD40 Tchem Non-IDG -3.44068 3018.0 1385
Tyrosine-protein kinase JAK3 JAK3 Tclin Kinase -2.57530 419.2 260
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.07639 11730.8 2241
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.63770 438.1 349
Mitogen-activated protein kinase 10 MAPK10 Tchem Kinase -2.24057 181.6 339
Phosphoinositide 3-kinase regulatory subunit 6 PIK3R6 Tbio Enzyme 0.00000 66
Baculoviral IAP repeat-containing protein 2 BIRC2 Tchem Non-IDG -2.49724 295.0 303