Development Level

Tchem 35 | 1,890
Tbio 26 | 10,625
Tclin 7 | 602

IMPC Term

preweaning lethality, complete... 4 | 633
abnormal lens morphology 2 | 73
decreased body weight 2 | 174
decreased circulating sodium l... 2 | 18
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal skin condition 1 | 6
abnormal startle reflex 1 | 14
cataract 1 | 26
decreased B cell number 1 | 30
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating fructosa... 1 | 31
decreased circulating magnesiu... 1 | 11
decreased circulating triglyce... 1 | 83
decreased fasted circulating g... 1 | 49
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased thermal nociceptive ... 1 | 4
embryonic lethality prior to t... 1 | 187
increased CD4-positive, alpha ... 1 | 15
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased body length 1 | 20
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased sacral vertebrae num... 1 | 62
increased thermal nociceptive ... 1 | 9
polydactyly 1 | 22
preweaning lethality, incomple... 1 | 260

Disease

Cancer 45 | 2,346
osteosarcoma 44 | 7,933
ovarian cancer 44 | 8,484
lung cancer 32 | 4,466
glioblastoma 30 | 5,572
psoriasis 27 | 6,685
medulloblastoma, large-cell 25 | 6,234
subependymal giant cell astrocytoma 24 | 2,287
Carcinoma 19 | 2,147
Rheumatoid Arthritis 19 | 1,160
atypical teratoid / rhabdoid tumor 19 | 4,369
lung carcinoma 19 | 2,844
ulcerative colitis 19 | 2,087
diabetes mellitus 16 | 1,663
interstitial cystitis 16 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,289
primary Sjogren syndrome 16 | 789
astrocytoma 15 | 1,493
invasive ductal carcinoma 15 | 2,950
non-small cell lung cancer 15 | 2,798
oligodendroglioma 15 | 2,849
pilocytic astrocytoma 15 | 3,086
Arthritis 14 | 248
Breast cancer 14 | 3,094
adult high grade glioma 14 | 2,148
pancreatic cancer 14 | 2,300
primitive neuroectodermal tumor 14 | 3,031
group 4 medulloblastoma 13 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
juvenile dermatomyositis 13 | 1,189
Lung Neoplasms 12 | 171
Waldenstrons macroglobulinemia 12 | 765
colon cancer 12 | 1,475
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
lung adenocarcinoma 12 | 2,713
Mammary Neoplasms 11 | 410
Pick disease 11 | 1,893
ependymoma 11 | 2,514
malignant mesothelioma 11 | 3,162
pediatric high grade glioma 11 | 2,712
pituitary cancer 11 | 1,972
tuberculosis 11 | 1,557
Multiple myeloma 10 | 1,327
Vascular disease 10 | 281
dermatomyositis 10 | 933
medulloblastoma 10 | 1,524
primary pancreatic ductal adenocarcinoma 10 | 1,271
Heart disease 9 | 279
cutaneous lupus erythematosus 9 | 1,056
cystic fibrosis 9 | 1,665
gastric carcinoma 9 | 832
nasopharyngeal carcinoma 9 | 1,056
Alzheimer's disease 8 | 644
Asthma 8 | 349
IGA Glomerulonephritis 8 | 454
Kidney disease 8 | 396
Lung disease 8 | 132
Multiple Sclerosis 8 | 498
acute myeloid leukemia 8 | 780
astrocytic glioma 8 | 2,241
Brain Ischemia 7 | 87
Obesity 7 | 616
Parkinson's disease 7 | 364
Renal Cell Carcinoma 7 | 199
Reperfusion Injury 7 | 84
Schizophrenia 7 | 501
acute quadriplegic myopathy 7 | 1,157
breast carcinoma 7 | 1,614
group 3 medulloblastoma 7 | 2,254
Diffuse large B-cell lymphoma 6 | 41
Liver carcinoma 6 | 217
Lymphoma 6 | 56
Neoplastic Cell Transformation 6 | 81
Prostatic Neoplasms 6 | 471
Squamous cell carcinoma 6 | 94
Stomach Neoplasms 6 | 282
Toxic encephalopathy 6 | 131
active Crohn's disease 6 | 918
ductal carcinoma in situ 6 | 1,745
ovarian neoplasm 6 | 97
periodontitis 6 | 269
posterior fossa group A ependymoma 6 | 1,511
spina bifida 6 | 1,064
Acquired immunodeficiency syndrome 5 | 164
Agammaglobulinemia 5 | 24
Allergic hypersensitivity disease 5 | 123
Brain disease 5 | 83
Eye disease 5 | 55
Inflammatory bowel disease 5 | 142
Intellectual disability 5 | 573
LEOPARD Syndrome 5 | 20
Neoplasm Invasiveness 5 | 127
Noonan Syndrome 5 | 33
Osteoporosis 5 | 257
aldosterone-producing adenoma 5 | 664
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
posterior fossa group B ependymoma 5 | 1,530
Duchenne muscular dystrophy 4 | 602
nephrosclerosis 4 | 329
sonic hedgehog group medulloblastoma 4 | 1,482

Tissue

Blood and immune system 68 | 17,995
Cardiovascular System 68 | 17,958
Digestive Tract 68 | 18,473
Endocrine System 68 | 18,512
Female tissues 68 | 18,647
Liver and Pancreas 68 | 18,136
Male tissues 68 | 17,969
Nervous System 68 | 18,561
Respiratory system 68 | 17,484
Urinary Tract 68 | 18,444
Skin and soft tissues 67 | 18,115

Target Family

Non-IDG 24 | 11,971
Kinase 22 | 634
Enzyme 13 | 4,146
Transcription Factor 9 | 1,400

PathwayCommons: pid Pathway

BCR signaling pathway 68 | 68
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Breakpoint cluster region protein BCR Tclin Non-IDG -2.96152 896.0 391
NF-kappa-B inhibitor alpha NFKBIA Tchem Non-IDG -3.34160 1960.9 1181
POU domain, class 2, transcription factor 2 POU2F2 Tchem Transcription Factor -1.45774 28.7 332
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424
3-phosphoinositide-dependent protein kinase 1 PDPK1 Tchem Kinase -2.24871 191.5 579
Tyrosine-protein kinase BTK BTK Tclin Kinase -2.98909 1061.8 721
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA Tchem Enzyme -2.95943 932.4 290
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.37849 233.2 634