Development Level

Tbio 22 | 10,625
Tclin 10 | 602
Tchem 4 | 1,890

IMPC Term

abnormal behavior 2 | 226
decreased circulating triglyce... 2 | 83
decreased prepulse inhibition 2 | 52
decreased total body fat amoun... 2 | 186
thrombocytopenia 2 | 46
abnormal bone mineralization 1 | 55
abnormal femur morphology 1 | 14
abnormal vocalization 1 | 21
cardiovascular system phenotyp... 1 | 35
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased brain size 1 | 4
decreased circulating amylase ... 1 | 24
decreased circulating glucose ... 1 | 121
decreased circulating phosphat... 1 | 15
decreased circulating total pr... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased leukocyte cell numbe... 1 | 54
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular vol... 1 | 50
fusion of vertebral arches 1 | 7
increased CD4-positive, CD25-p... 1 | 18
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased sacral vertebrae num... 1 | 62
no abnormal phenotype detected 1 | 3
polysyndactyly 1 | 2
small heart 1 | 8
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 11
small stomach 1 | 3
small thymus 1 | 11
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

osteosarcoma 25 | 7,933
ovarian cancer 22 | 8,484
glioblastoma 18 | 5,572
Cancer 16 | 2,346
lung cancer 16 | 4,466
medulloblastoma, large-cell 16 | 6,234
atypical teratoid / rhabdoid tumor 15 | 4,369
psoriasis 15 | 6,685
group 4 medulloblastoma 12 | 1,875
non-small cell lung cancer 12 | 2,798
Breast cancer 11 | 3,094
lung carcinoma 11 | 2,844
malignant mesothelioma 11 | 3,162
colon cancer 9 | 1,475
ependymoma 9 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
invasive ductal carcinoma 9 | 2,950
pancreatic cancer 9 | 2,300
pilocytic astrocytoma 9 | 3,086
primitive neuroectodermal tumor 9 | 3,031
tuberculosis 9 | 1,557
Carcinoma 8 | 2,147
astrocytic glioma 8 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
ulcerative colitis 8 | 2,087
adult high grade glioma 7 | 2,148
ductal carcinoma in situ 7 | 1,745
oligodendroglioma 7 | 2,849
pituitary cancer 7 | 1,972
cutaneous lupus erythematosus 6 | 1,056
interstitial cystitis 6 | 2,299
lung adenocarcinoma 6 | 2,713
medulloblastoma 6 | 1,524
pediatric high grade glioma 6 | 2,712
spina bifida 6 | 1,064
Neoplasm Invasiveness 5 | 127
Neoplasm Metastasis 5 | 138
adrenocortical carcinoma 5 | 1,427
breast carcinoma 5 | 1,614
diabetes mellitus 5 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
subependymal giant cell astrocytoma 5 | 2,287
Autistic Disorder 4 | 320
Coronary artery disease 4 | 240
Kidney disease 4 | 396
Liver carcinoma 4 | 217
Mammary Neoplasms 4 | 410
Prostatic Neoplasms 4 | 471
Rheumatoid Arthritis 4 | 1,160
astrocytoma 4 | 1,493
group 3 medulloblastoma 4 | 2,254
juvenile dermatomyositis 4 | 1,189
Adenocarcinoma 3 | 115
Amyotrophic Lateral Sclerosis 3 | 431
Atopic dermatitis 3 | 944
Cerebrovascular accident 3 | 44
Cerebrovascular disease 3 | 231
Chronic Lymphocytic Leukemia 3 | 242
Disease Progression 3 | 125
Fibrous dysplasia 3 | 15
Heart disease 3 | 279
Lung Neoplasms 3 | 171
McCune Albright syndrome 3 | 19
Peripheral Neuropathy 3 | 303
Polycystic Ovary Syndrome 3 | 332
Squamous cell carcinoma 3 | 94
Stomach Neoplasms 3 | 282
esophageal adenocarcinoma 3 | 737
non-small cell lung carcinoma 3 | 413
pancreatic carcinoma 3 | 567
posterior fossa group A ependymoma 3 | 1,511
primary Sjogren syndrome 3 | 789
Adenoma 2 | 165
Atherosclerosis 2 | 275
Autoimmune thrombocytopenic purpura 2 | 14
Bladder Neoplasm 2 | 109
Cardiomyopathies 2 | 90
Colonic Neoplasms 2 | 126
Congenital Heart Defects 2 | 37
Craniofacial Abnormalities 2 | 147
Down syndrome 2 | 548
Hypertension 2 | 287
Juvenile arthritis 2 | 124
Kidney Diseases 2 | 86
Neuroblastoma 2 | 78
Nonsyndromic deafness 2 | 121
Proteinuria 2 | 63
Reperfusion Injury 2 | 84
Thrombocytopenia 2 | 105
Vascular disease 2 | 281
active Crohn's disease 2 | 918
active ulcerative colitis 2 | 477
acute quadriplegic myopathy 2 | 1,157
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
cystic fibrosis 2 | 1,665
facioscapulohumeral dystrophy 2 | 286
nasopharyngeal carcinoma 2 | 1,056
progressive supranuclear palsy 2 | 674
urothelial carcinoma 2 | 318

Tissue

Blood and immune system 36 | 17,995
Cardiovascular System 36 | 17,958
Digestive Tract 36 | 18,473
Endocrine System 36 | 18,512
Female tissues 36 | 18,647
Liver and Pancreas 36 | 18,136
Male tissues 36 | 17,969
Nervous System 36 | 18,561
Respiratory system 36 | 17,484
Skin and soft tissues 36 | 18,115
Urinary Tract 36 | 18,444

Target Family

Non-IDG 23 | 11,971
Kinase 5 | 634
Enzyme 4 | 4,146
GPCR 4 | 406

PathwayCommons: pid Pathway

Arf6 signaling events 36 | 36
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 ARAP2 Tbio Non-IDG -1.61041 39.0 69
Hepatocyte growth factor HGF Tchem Enzyme -3.28069 2317.3 573
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.80612 564.2 147
ADP-ribosylation factor 6 ARF6 Tchem Enzyme -2.45898 333.2 252
Cytohesin-3 CYTH3 Tbio Non-IDG -1.80144 68.4 143
Interactor protein for cytohesin exchange factors 1 IPCEF1 Tbio Non-IDG -0.33849 2.87 67
Guanine nucleotide-binding protein G(q) subunit alpha GNAQ Tbio Non-IDG -2.70830 492.8 177
Pro-epidermal growth factor EGF Tbio Non-IDG -3.74376 4837.7 851
PH and SEC7 domain-containing protein 1 PSD Tbio Non-IDG -2.09883 131.3 16