Development Level

Tbio 25 | 10,625
Tchem 14 | 1,890

IMPC Term

preweaning lethality, complete... 8 | 633
embryonic lethality prior to o... 4 | 148
embryonic lethality prior to t... 4 | 187
abnormal bone structure 2 | 131
increased mean corpuscular vol... 2 | 91
abnormal behavioral response t... 1 | 52
abnormal blood vessel morpholo... 1 | 2
abnormal retina morphology 1 | 100
abnormal skin morphology 1 | 23
cardiovascular system phenotyp... 1 | 35
decreased bone mineral content 1 | 157
decreased circulating glucose ... 1 | 121
decreased circulating potassiu... 1 | 17
decreased fasted circulating g... 1 | 49
decreased heart rate variabili... 1 | 11
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
enlarged lymph nodes 1 | 27
hydrops fetalis 1 | 22
increased circulating alkaline... 1 | 119
increased circulating sodium l... 1 | 71
increased exploration in new e... 1 | 56
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
thrombocytopenia 1 | 46

Disease

ovarian cancer 31 | 8,484
Cancer 23 | 2,346
glioblastoma 23 | 5,572
psoriasis 23 | 6,685
medulloblastoma, large-cell 22 | 6,234
lung cancer 20 | 4,466
osteosarcoma 20 | 7,933
malignant mesothelioma 19 | 3,162
non-small cell lung cancer 18 | 2,798
group 3 medulloblastoma 16 | 2,254
primitive neuroectodermal tumor 16 | 3,031
colon cancer 15 | 1,475
pediatric high grade glioma 15 | 2,712
Breast cancer 14 | 3,094
atypical teratoid / rhabdoid tumor 14 | 4,369
adrenocortical carcinoma 12 | 1,427
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
lung adenocarcinoma 11 | 2,713
atypical teratoid/rhabdoid tumor 10 | 1,095
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
nasopharyngeal carcinoma 10 | 1,056
invasive ductal carcinoma 9 | 2,950
ductal carcinoma in situ 8 | 1,745
Ataxia telangiectasia 7 | 31
Endometriosis 7 | 535
sonic hedgehog group medulloblastoma 7 | 1,482
Carcinoma 6 | 2,147
Peripheral Neuropathy 6 | 303
Waldenstrons macroglobulinemia 6 | 765
astrocytic glioma 6 | 2,241
oligodendroglioma 6 | 2,849
pituitary cancer 6 | 1,972
posterior fossa group A ependymoma 6 | 1,511
ulcerative colitis 6 | 2,087
Atopic dermatitis 5 | 944
Nijmegen breakage syndrome 5 | 23
Seckel syndrome 5 | 34
adult high grade glioma 5 | 2,148
breast carcinoma 5 | 1,614
diabetes mellitus 5 | 1,663
pancreatic cancer 5 | 2,300
Bloom syndrome 4 | 30
IGA Glomerulonephritis 4 | 454
Mammary Neoplasms 4 | 410
Pick disease 4 | 1,893
dermatomyositis 4 | 933
ependymoma 4 | 2,514
Anemia 3 | 252
Chronic Lymphocytic Leukemia 3 | 242
Fanconi's anemia 3 | 50
Hereditary Breast and Ovarian Cancer Syndrome 3 | 14
Intellectual disability 3 | 573
Malignant neoplasm of breast 3 | 63
Multiple myeloma 3 | 1,327
Parkinson's disease 3 | 364
Prostatic Neoplasms 3 | 471
active Crohn's disease 3 | 918
acute quadriplegic myopathy 3 | 1,157
inflammatory breast cancer 3 | 404
juvenile dermatomyositis 3 | 1,189
lung carcinoma 3 | 2,844
medulloblastoma 3 | 1,524
non primary Sjogren syndrome sicca 3 | 840
tuberculosis 3 | 1,557
tuberculosis and treatment for 6 months 3 | 686
Aplastic anemia 2 | 18
Asthma 2 | 349
Bipolar Disorder 2 | 266
Breast Cancer, Familial 2 | 12
Cervix endometriosis 2 | 3
Fanconi Anemia 2 | 19
Glioma 2 | 65
Li-Fraumeni Syndrome 2 | 13
Meier-Gorlin syndrome 2 | 12
Melanoma 2 | 261
Microcephaly 2 | 149
Neoplastic Syndromes, Hereditary 2 | 48
Prostate cancer 2 | 172
Prostate cancer, familial 2 | 13
Schimke immuno-osseous dysplasia 2 | 9
astrocytoma 2 | 1,493
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
cystic fibrosis 2 | 1,665
glioblastoma multiforme 2 | 347
group 4 medulloblastoma 2 | 1,875
interstitial cystitis 2 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
pilocytic astrocytoma 2 | 3,086
primary pancreatic ductal adenocarcinoma 2 | 1,271
subependymal giant cell astrocytoma 2 | 2,287
Animal Mammary Neoplasms 1 | 136
Autosomal dominant cerebellar ataxia 1 | 34
Cerebellar Ataxia 1 | 72
Dysplastic nevus syndrome 1 | 7
Friedreich ataxia 1 | 23
HIV Infections 1 | 100
Lipoma 1 | 19
Mammary Neoplasms, Experimental 1 | 150
Pancreatic carcinoma, familial 1 | 8
Seborrheic keratosis 1 | 6

Tissue

Blood and immune system 39 | 17,995
Cardiovascular System 39 | 17,958
Digestive Tract 39 | 18,473
Endocrine System 39 | 18,512
Female tissues 39 | 18,647
Liver and Pancreas 39 | 18,136
Male tissues 39 | 17,969
Nervous System 39 | 18,561
Respiratory system 39 | 17,484
Skin and soft tissues 39 | 18,115
Urinary Tract 39 | 18,444

Target Family

Non-IDG 28 | 11,971
Enzyme 7 | 4,146
Kinase 4 | 634

PathwayCommons: pid Pathway

ATR signaling pathway 39 | 39
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
AP-1 transcription factor netw... 71 | 71
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
Centrosomal protein of 164 kDa CEP164 Tbio Non-IDG -0.96655 10.2 84
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.34287 19.7 194
Replication factor C subunit 4 RFC4 Tbio Non-IDG -1.13105 13.0 167
Breast cancer type 2 susceptibility protein BRCA2 Tbio Non-IDG -3.42019 2495.6 219
F-box/WD repeat-containing protein 11 FBXW11 Tbio Non-IDG -0.55076 5.61 153
Protein timeless homolog TIMELESS Tbio Non-IDG -2.73257 550.7 135