Development Level

Tbio 40 | 10,625
Tchem 26 | 1,890
Tclin 5 | 602

IMPC Term

decreased total body fat amoun... 3 | 186
short tibia 3 | 82
abnormal femur morphology 2 | 14
abnormal lens morphology 2 | 73
decreased heart weight 2 | 44
embryonic lethality prior to t... 2 | 187
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
preweaning lethality, complete... 2 | 633
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal forebrain development 1 | 18
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 24
abnormal humerus morphology 1 | 11
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal optic disc morphology 1 | 10
abnormal ovary morphology 1 | 3
abnormal retinal pigmentation 1 | 61
abnormal spinal cord morpholog... 1 | 8
abnormal startle reflex 1 | 14
absent epididymis 1 | 2
absent seminal vesicle 1 | 2
absent testes 1 | 2
cataract 1 | 26
decreased body length 1 | 108
decreased body weight 1 | 174
decreased circulating alanine ... 1 | 53
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased lean body mass 1 | 195
decreased macrophage cell numb... 1 | 4
decreased mean corpuscular vol... 1 | 50
dilated heart left ventricle 1 | 10
enlarged heart 1 | 111
female infertility 1 | 34
increased IgG2b level 1 | 1
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased or absent threshold ... 1 | 128
increased startle reflex 1 | 38
male infertility 1 | 62
preweaning lethality, incomple... 1 | 260

Disease

Cancer 54 | 2,346
ovarian cancer 48 | 8,484
psoriasis 43 | 6,685
glioblastoma 38 | 5,572
lung cancer 36 | 4,466
osteosarcoma 35 | 7,933
medulloblastoma, large-cell 30 | 6,234
ulcerative colitis 29 | 2,087
atypical teratoid / rhabdoid tumor 27 | 4,369
diabetes mellitus 27 | 1,663
non-small cell lung cancer 26 | 2,798
pancreatic cancer 26 | 2,300
malignant mesothelioma 24 | 3,162
interstitial cystitis 23 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,956
lung adenocarcinoma 23 | 2,713
lung carcinoma 23 | 2,844
pituitary cancer 23 | 1,972
Prostatic Neoplasms 22 | 471
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,988
invasive ductal carcinoma 22 | 2,950
Breast cancer 20 | 3,094
Kidney disease 20 | 396
breast carcinoma 20 | 1,614
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,289
pilocytic astrocytoma 20 | 3,086
tuberculosis 20 | 1,557
Asthma 19 | 349
Multiple Sclerosis 19 | 498
group 4 medulloblastoma 19 | 1,875
primitive neuroectodermal tumor 19 | 3,031
Lung Neoplasms 18 | 171
Obesity 18 | 616
Rheumatoid Arthritis 18 | 1,160
astrocytoma 18 | 1,493
Arthritis 17 | 248
Mammary Neoplasms 17 | 410
Vascular disease 17 | 281
adrenocortical carcinoma 17 | 1,427
ductal carcinoma in situ 17 | 1,745
pediatric high grade glioma 17 | 2,712
Heart disease 16 | 279
Liver carcinoma 16 | 217
primary pancreatic ductal adenocarcinoma 16 | 1,271
colon cancer 15 | 1,475
cystic fibrosis 15 | 1,665
gastric carcinoma 15 | 832
Endometriosis 14 | 535
Lung disease 14 | 132
juvenile dermatomyositis 14 | 1,189
oligodendroglioma 14 | 2,849
posterior fossa group A ependymoma 14 | 1,511
subependymal giant cell astrocytoma 14 | 2,287
Hypertension 13 | 287
Inflammatory bowel disease 13 | 142
Liver disease 13 | 219
Reperfusion Injury 13 | 84
ependymoma 13 | 2,514
Atherosclerosis 12 | 275
Cerebrovascular disease 12 | 231
Hypersensitivity reaction type II disease 12 | 235
Inflammation 12 | 109
Neoplasm Metastasis 12 | 138
acute quadriplegic myopathy 12 | 1,157
nasopharyngeal carcinoma 12 | 1,056
periodontitis 12 | 269
Alzheimer's disease 11 | 644
Anemia 11 | 252
Carcinoma 11 | 2,147
Coronary artery disease 11 | 240
Hypertensive disease 11 | 193
Multiple myeloma 11 | 1,327
Neoplasm Invasiveness 11 | 127
Schizophrenia 11 | 501
aldosterone-producing adenoma 11 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 499
inflammatory breast cancer 11 | 404
Adenoma 10 | 165
Allergic hypersensitivity disease 10 | 123
Allergic rhinitis 10 | 91
Atopic dermatitis 10 | 944
Dermatitis 10 | 107
IGA Glomerulonephritis 10 | 454
Influenza 10 | 142
Liver Cirrhosis 10 | 101
Myocardial Infarction 10 | 126
Neoplastic Cell Transformation 10 | 81
Pulmonary Fibrosis 10 | 66
Waldenstrons macroglobulinemia 10 | 765
esophageal adenocarcinoma 10 | 737
hepatocellular carcinoma 10 | 532
Crohn's disease 9 | 304
Eosinophilia 9 | 65
Pancreatic Neoplasm 9 | 79
Parkinson's disease 9 | 364
Stomach Neoplasms 9 | 282
acute myeloid leukemia 9 | 780
adult high grade glioma 9 | 2,148
medulloblastoma 9 | 1,524
nephrosclerosis 9 | 329

Tissue

Endocrine System 71 | 18,512
Cardiovascular System 70 | 17,958
Digestive Tract 70 | 18,473
Female tissues 70 | 18,647
Nervous System 70 | 18,561
Respiratory system 70 | 17,484
Skin and soft tissues 70 | 18,115
Urinary Tract 70 | 18,444
Blood and immune system 69 | 17,995
Liver and Pancreas 69 | 18,136
Male tissues 68 | 17,969

Target Family

Non-IDG 30 | 11,971
Transcription Factor 27 | 1,400
Enzyme 10 | 4,146
Nuclear Receptor 2 | 48
Epigenetic 1 | 242
Kinase 1 | 634

PathwayCommons: pid Pathway

AP-1 transcription factor netw... 71 | 71
Direct p53 effectors 137 | 137
PDGFR-beta signaling pathway 125 | 125
ErbB1 downstream signaling 103 | 103
C-MYB transcription factor net... 87 | 87
CXCR4-mediated signaling event... 87 | 87
Glucocorticoid receptor regula... 85 | 85
Regulation of nuclear SMAD2/3 ... 82 | 82
Regulation of nuclear beta cat... 80 | 80
Signaling events mediated by H... 80 | 80
Validated targets of C-MYC tra... 80 | 80
p73 transcription factor netwo... 80 | 80
E2F transcription factor netwo... 77 | 77
Signaling events mediated by H... 74 | 74
p75(NTR)-mediated signaling 74 | 74
CDC42 signaling events 71 | 71
Beta1 integrin cell surface in... 70 | 70
Regulation of Telomerase 70 | 70
TCR signaling in naïve CD4+ T ... 69 | 69
BCR signaling pathway 68 | 68
HIF-1-alpha transcription fact... 67 | 67
Regulation of retinoblastoma p... 67 | 67
Signaling events mediated by V... 67 | 67
Downstream signaling in naïve ... 66 | 66
IL4-mediated signaling events 66 | 66
Integrins in angiogenesis 66 | 66
mTOR signaling pathway 66 | 66
LPA receptor mediated events 65 | 65
Validated nuclear estrogen rec... 65 | 65
Endothelins 64 | 64
Fc-epsilon receptor I signalin... 64 | 64
Neurotrophic factor-mediated T... 63 | 63
Signaling events mediated by f... 63 | 63
Validated targets of C-MYC tra... 63 | 63
IL12-mediated signaling events 62 | 62
Coregulation of Androgen recep... 61 | 61
SHP2 signaling 60 | 60
ATF-2 transcription factor net... 59 | 59
p53 pathway 59 | 59
Notch signaling pathway 58 | 58
Caspase Cascade in Apoptosis 57 | 57
TCR signaling in naïve CD8+ T ... 56 | 56
Thromboxane A2 receptor signal... 56 | 56
FGF signaling pathway 55 | 55
IL2-mediated signaling events 54 | 54
RAC1 signaling pathway 54 | 54
Regulation of Androgen recepto... 54 | 54
Validated transcriptional targ... 54 | 54
Signaling events mediated by P... 53 | 53
Signaling events mediated by S... 53 | 53
TGF-beta receptor signaling 53 | 53
Role of Calcineurin-dependent ... 52 | 52
Angiopoietin receptor Tie2-med... 50 | 50
FoxO family signaling 50 | 50
Posttranslational regulation o... 50 | 50
Ceramide signaling pathway 49 | 49
Hedgehog signaling events medi... 49 | 49
Arf6 trafficking events 48 | 48
Calcineurin-regulated NFAT-dep... 48 | 48
Fanconi anemia pathway 48 | 48
IL6-mediated signaling events 48 | 48
Notch-mediated HES/HEY network 48 | 48
PLK1 signaling events 48 | 48
Regulation of RhoA activity 48 | 48
Validated transcriptional targ... 48 | 48
Insulin Pathway 47 | 47
Class I PI3K signaling events 46 | 46
Integrin-linked kinase signali... 46 | 46
Presenilin action in Notch and... 46 | 46
RhoA signaling pathway 46 | 46
TNF receptor signaling pathway... 46 | 46
a6b1 and a6b4 Integrin signali... 46 | 46
FOXA1 transcription factor net... 45 | 45
FOXA2 and FOXA3 transcription ... 45 | 45
Beta3 integrin cell surface in... 44 | 44
LKB1 signaling events 43 | 43
PAR1-mediated thrombin signali... 43 | 43
Signaling events mediated by H... 43 | 43
Stabilization and expansion of... 43 | 43
BMP receptor signaling 42 | 42
Plasma membrane estrogen recep... 42 | 42
Syndecan-1-mediated signaling ... 42 | 42
Urokinase-type plasminogen act... 42 | 42
ErbB2/ErbB3 signaling events 41 | 41
IFN-gamma pathway 41 | 41
Aurora B signaling 40 | 40
EPHB forward signaling 40 | 40
FOXM1 transcription factor net... 40 | 40
Signaling events mediated by T... 40 | 40
ATR signaling pathway 39 | 39
Regulation of RAC1 activity 39 | 39
Signaling events regulated by ... 39 | 39
CXCR3-mediated signaling event... 38 | 38
GMCSF-mediated signaling event... 38 | 38
Internalization of ErbB1 38 | 38
Syndecan-2-mediated signaling ... 38 | 38
E-cadherin signaling in the na... 37 | 37
IL23-mediated signaling events 37 | 37
Validated transcriptional targ... 37 | 37
CD40/CD40L signaling 36 | 36

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Metallothionein-2 MT2A Tbio Non-IDG -2.42641 259.2 92
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.90528 8199.7 1129