Development Level

Tchem 71 | 1,598
Tbio 51 | 11,445
Tclin 24 | 613

Collection

Kinase: IDG Consortium (Target... 5 | 125

IMPC Phenotype

preweaning lethality, complete... 13 | 979
preweaning lethality, incomple... 8 | 499
embryonic lethality prior to t... 6 | 278
abnormal behavior 4 | 298
abnormal retina morphology 4 | 71
decreased total body fat amoun... 4 | 207
abnormal gait 3 | 69
increased bone mineral density 3 | 72
increased circulating alkaline... 3 | 122
increased spleen weight 3 | 10
thrombocytopenia 3 | 56
abnormal bone mineralization 2 | 38
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
decreased body length 2 | 101
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased circulating serum al... 2 | 82
decreased circulating sodium l... 2 | 22
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased blood urea nitrogen ... 2 | 48
increased circulating triglyce... 2 | 42
increased mean corpuscular hem... 2 | 96
increased neutrophil cell numb... 2 | 46
increased startle reflex 2 | 112
male infertility 2 | 123
short tibia 2 | 97
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal duodenum morphology 1 | 4
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 20
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal vocalization 1 | 21
cataract 1 | 92
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating magnesiu... 1 | 13
decreased circulating triglyce... 1 | 79
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
edema 1 | 59
enlarged kidney 1 | 14
enlarged spleen 1 | 41
female infertility 1 | 60
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased B cell number 1 | 9
increased T cell number 1 | 6
increased aggression 1 | 4
increased body length 1 | 32
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating phosphat... 1 | 26
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
prenatal lethality prior to he... 1 | 87
shortened RR interval 1 | 17
small testis 1 | 58

Disease

Carcinoma 113 | 11,493
ovarian cancer 95 | 8,520
Cancer 93 | 2,499
osteosarcoma 90 | 7,950
glioblastoma 81 | 5,792
medulloblastoma, large-cell 81 | 6,241
psoriasis 70 | 6,694
atypical teratoid / rhabdoid tumor 69 | 5,112
ependymoma 59 | 4,679
lung cancer 58 | 4,740
primitive neuroectodermal tumor 48 | 3,035
Breast cancer 47 | 3,578
oligodendroglioma 46 | 2,850
group 3 medulloblastoma 45 | 4,104
adult high grade glioma 44 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 41 | 3,291
pancreatic cancer 40 | 2,398
diabetes mellitus 39 | 1,728
Astrocytoma, Pilocytic 38 | 3,081
lung adenocarcinoma 37 | 2,716
malignant mesothelioma 37 | 3,232
subependymal giant cell astrocytoma 36 | 2,287
Schizophrenia 35 | 1,160
group 4 medulloblastoma 35 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 35 | 2,989
lung carcinoma 35 | 2,843
Kidney cancer 33 | 2,613
non-small cell lung cancer 33 | 2,890
tuberculosis 33 | 2,010
Pick disease 32 | 1,894
invasive ductal carcinoma 32 | 2,951
astrocytic glioma 31 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,955
Vascular disease 29 | 319
colon cancer 28 | 1,478
Rheumatoid arthritis 27 | 1,191
interstitial cystitis 27 | 2,312
astrocytoma 26 | 1,146
ulcerative colitis 26 | 1,819
Obesity 25 | 678
pituitary cancer 25 | 1,972
Multiple myeloma 24 | 1,332
breast carcinoma 24 | 1,638
Breast Neoplasms 22 | 445
Mammary Neoplasms 22 | 425
Stomach Neoplasms 22 | 300
Prostatic Neoplasms 21 | 495
adrenocortical carcinoma 21 | 1,428
Arthritis 20 | 290
Parkinson's disease 20 | 392
cystic fibrosis 20 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,962
pediatric high grade glioma 20 | 1,064
Hypertension 19 | 396
Intellectual disability 19 | 1,016
acute quadriplegic myopathy 19 | 1,158
juvenile dermatomyositis 19 | 1,187
Alzheimer's disease 18 | 658
Bipolar Disorder 18 | 666
Kidney disease 18 | 430
ductal carcinoma in situ 18 | 1,745
Depressive disorder 17 | 409
Reperfusion Injury 17 | 86
Seizures 17 | 596
primary pancreatic ductal adenocarcinoma 17 | 1,109
Carcinoma, Hepatocellular 16 | 228
Epilepsy 16 | 792
Liver carcinoma 16 | 240
Neoplasm Invasiveness 16 | 161
Waldenstrons macroglobulinemia 16 | 765
Asthma 15 | 385
Heart disease 15 | 306
Hypertensive disease 15 | 292
Muscle hypotonia 15 | 571
Neoplasm Metastasis 15 | 168
dermatomyositis 15 | 966
Brain Ischemia 14 | 110
Cell Transformation, Neoplastic 14 | 97
Dull intelligence 14 | 645
Hyperalgesia 14 | 83
Hyperglycemia 14 | 137
Low intelligence 14 | 645
Lung Neoplasms 14 | 232
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Poor school performance 14 | 645
Renal Cell Carcinoma 14 | 214
spina bifida 14 | 1,074
Colorectal Neoplasms 13 | 243
Endometriosis 13 | 540
Liver Cirrhosis, Experimental 13 | 769
Melanoma 13 | 711
Myocardial Infarction 13 | 151
Atherosclerosis 12 | 291
Cerebrovascular disease 12 | 238
Down syndrome 12 | 499
Lung disease 12 | 142
Mental Depression 12 | 333
acute myeloid leukemia 12 | 783
primary Sjogren syndrome 12 | 735

Tissue

Endocrine System 145 | 18,159
Digestive Tract 144 | 17,369
Male tissues 144 | 17,142
Female tissues 143 | 17,400
Nervous System 143 | 16,725
Skin and soft tissues 143 | 17,230
Blood and immune system 142 | 16,909
Liver and Pancreas 142 | 16,750
Respiratory system 142 | 16,393
Urinary Tract 141 | 16,678
Cardiovascular System 137 | 15,192

Target Family

Kinase 52 | 634
Non-IDG 40 | 12,091
Enzyme 21 | 4,145
Transcription Factor 21 | 1,400
Ion Channel 6 | 344
Epigenetic 2 | 242
Nuclear Receptor 2 | 48
GPCR 1 | 408
Transporter 1 | 473

PathwayCommons: panther Pathway

http://identifiers.org/panther... 146 | 146
http://identifiers.org/panther... 264 | 264
http://identifiers.org/panther... 197 | 197
http://identifiers.org/panther... 164 | 164
http://identifiers.org/panther... 151 | 151
http://identifiers.org/panther... 150 | 150
http://identifiers.org/panther... 149 | 149
http://identifiers.org/panther... 124 | 124
http://identifiers.org/panther... 118 | 118
http://identifiers.org/panther... 116 | 116
http://identifiers.org/panther... 115 | 115
http://identifiers.org/panther... 110 | 110
http://identifiers.org/panther... 107 | 107
http://identifiers.org/panther... 104 | 104
http://identifiers.org/panther... 91 | 91
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 86 | 86
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 67 | 67
http://identifiers.org/panther... 65 | 65
http://identifiers.org/panther... 63 | 63
http://identifiers.org/panther... 61 | 61
http://identifiers.org/panther... 60 | 60
http://identifiers.org/panther... 56 | 56
http://identifiers.org/panther... 54 | 54
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 51 | 51
http://identifiers.org/panther... 47 | 47
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 44 | 44
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 41 | 41
http://identifiers.org/panther... 38 | 38
http://identifiers.org/panther... 37 | 37
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 33 | 33
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 31 | 31
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 27 | 27
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 17 | 17
http://identifiers.org/panther... 16 | 16
http://identifiers.org/panther... 15 | 15
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 13 | 13
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 8 | 8
http://identifiers.org/panther... 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Retinal guanylyl cyclase 1 GUCY2D Tbio Kinase -2.20658 167.7 205
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A Tclin Enzyme -1.27429 21.3 169
Krueppel-like factor 4 KLF4 Tbio Transcription Factor -2.89447 774.1 686
Ribosomal protein S6 kinase alpha-3 RPS6KA3 Tchem Kinase -2.50143 325.4 425
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 CD38 Tclin Enzyme -3.44680 2663.1 1493
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461