Development Level

Tchem 3 | 1,598
Tclin 3 | 613
Tbio 2 | 11,445

IMPC Phenotype

abnormal heart morphology 2 | 162
decreased circulating HDL chol... 2 | 68
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal fibula morphology 1 | 2
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal rib morphology 1 | 10
abnormal scapula morphology 1 | 3
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
absent mammary gland 1 | 1
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating calcium ... 1 | 36
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased skeletal muscle mass 1 | 1
decreased vertical activity 1 | 208
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
short tibia 1 | 97
small heart 1 | 10
small kidney 1 | 16
small ovary 1 | 1
small spleen 1 | 19
small uterus 1 | 3
thin skin 1 | 2

Disease

Carcinoma 7 | 11,493
Cancer 6 | 2,499
psoriasis 5 | 6,694
Autosomal recessive predisposition 4 | 1,442
lung carcinoma 4 | 2,843
osteosarcoma 4 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Hyperparathyroidism 3 | 48
Hypophosphatemia 3 | 40
Multiple Sclerosis 3 | 540
Osteomalacia 3 | 35
Osteoporosis 3 | 363
Rickets 3 | 49
Schizophrenia 3 | 1,160
invasive ductal carcinoma 3 | 2,951
malignant mesothelioma 3 | 3,232
nephrosclerosis 3 | 333
pituitary cancer 3 | 1,972
'Bulging' epiphyses 2 | 3
'Bulging' of the costochondral junction 2 | 2
Abdominal wall muscle weakness 2 | 6
Alkaline phosphatase serum increased 2 | 29
Alopecia 2 | 115
Bipolar Disorder 2 | 666
Bone Diseases, Metabolic 2 | 14
Bone pain 2 | 42
Breast Neoplasms 2 | 445
Chronic Lymphocytic Leukemia 2 | 262
Defective enamel matrix 2 | 35
Deformed rib cage 2 | 2
Delayed epiphyseal ossification 2 | 10
Delayed maturation of end part of long bone 2 | 10
Dental Enamel Hypoplasia 2 | 43
Difficulty standing 2 | 3
Difficulty walking 2 | 28
Dysplasia of tooth enamel 2 | 35
Enlargement of the ankles 2 | 3
Enlargement of the wrists 2 | 5
Failure to gain weight 2 | 365
Femoral bowing 2 | 20
Fibular bowing 2 | 5
Flat back of the head 2 | 26
Flat occiput 2 | 26
Frequent fractures 2 | 53
Frontal bossing 2 | 157
Genu varum 2 | 29
Growth delay 2 | 114
Growth failure 2 | 114
Growth retardation 2 | 115
Hypercalcemia 2 | 59
Hyperparathyroidism Secondary to Chronic Renal Failure 2 | 2
Hyperparathyroidism, Secondary 2 | 7
Hyperphosphatemia 2 | 32
Hypertension 2 | 396
Hypervitaminosis D 2 | 8
Hypocalcemia 2 | 32
Hypocalcemia from End-Stage Renal Disease with Dialysis 2 | 2
Hypoparathyroidism 2 | 41
Increased fracture rate 2 | 53
Increased serum parathyroid hormone 2 | 14
Irritation - emotion 2 | 68
Kaposi's Sarcoma Skin Lesions 2 | 8
Kidney disease 2 | 430
Late tooth eruption 2 | 61
Liver Cirrhosis 2 | 181
Mammary Neoplasms 2 | 425
Metabolic Bone Disorder 2 | 11
Metaphyseal irregularity 2 | 23
Motor delay 2 | 147
Muscle hypotonia 2 | 571
No development of motor milestones 2 | 147
Pediatric failure to thrive 2 | 365
Plaque psoriasis 2 | 17
Poor growth 2 | 114
Prostatic Neoplasms 2 | 495
Protuberant abdomen 2 | 16
Renal osteodystrophy 2 | 7
Sciatic Neuropathy 2 | 5
Sparse bone trabeculae 2 | 3
Subperiosteal erosions due to secondary hyperparathyroidism 2 | 2
Thin bony cortex 2 | 9
Thin dental enamel 2 | 35
Tibial bowing 2 | 19
Varying degree of multiple fractures 2 | 53
Very poor growth 2 | 114
Widely patent fontanels and sutures 2 | 12
adult high grade glioma 2 | 3,801
diabetes mellitus 2 | 1,728
fibroadenoma 2 | 559
glioblastoma 2 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung adenocarcinoma 2 | 2,716
lung cancer 2 | 4,740
medulloblastoma, large-cell 2 | 6,241
non-small cell lung cancer 2 | 2,890
ovarian cancer 2 | 8,520
pancreatic cancer 2 | 2,398
posterior fossa group A ependymoma 2 | 468
primitive neuroectodermal tumor 2 | 3,035
tuberculosis 2 | 2,010

Tissue

Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Liver and Pancreas 8 | 16,750
Urinary Tract 8 | 16,678
Blood and immune system 7 | 16,909
Female tissues 7 | 17,400
Male tissues 7 | 17,142
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Cardiovascular System 6 | 15,192

Target Family

Non-IDG 3 | 12,091
Nuclear Receptor 3 | 48
Enzyme 2 | 4,145

PathwayCommons: panther Pathway

http://identifiers.org/panther... 8 | 8
http://identifiers.org/panther... 264 | 264
http://identifiers.org/panther... 197 | 197
http://identifiers.org/panther... 164 | 164
http://identifiers.org/panther... 151 | 151
http://identifiers.org/panther... 150 | 150
http://identifiers.org/panther... 149 | 149
http://identifiers.org/panther... 146 | 146
http://identifiers.org/panther... 124 | 124
http://identifiers.org/panther... 118 | 118
http://identifiers.org/panther... 116 | 116
http://identifiers.org/panther... 115 | 115
http://identifiers.org/panther... 110 | 110
http://identifiers.org/panther... 107 | 107
http://identifiers.org/panther... 104 | 104
http://identifiers.org/panther... 91 | 91
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 86 | 86
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 67 | 67
http://identifiers.org/panther... 65 | 65
http://identifiers.org/panther... 63 | 63
http://identifiers.org/panther... 61 | 61
http://identifiers.org/panther... 60 | 60
http://identifiers.org/panther... 56 | 56
http://identifiers.org/panther... 54 | 54
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 51 | 51
http://identifiers.org/panther... 47 | 47
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 44 | 44
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 41 | 41
http://identifiers.org/panther... 38 | 38
http://identifiers.org/panther... 37 | 37
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 33 | 33
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 31 | 31
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 27 | 27
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 17 | 17
http://identifiers.org/panther... 16 | 16
http://identifiers.org/panther... 15 | 15
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 13 | 13
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Vitamin D3 receptor VDR Tclin Nuclear Receptor -3.62166 3805.7 575
Cytochrome P450 27C1 CYP27C1 Tbio Non-IDG -0.55429 3.51 47
Vitamin D-binding protein GC Tchem Non-IDG -3.07485 1140.6 428
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 Tchem Enzyme -2.70628 492.9 68
Sterol 26-hydroxylase, mitochondrial CYP27A1 Tchem Enzyme -2.99010 980.2 164
Retinoic acid receptor alpha RARA Tclin Nuclear Receptor -2.97339 919.3 562
Retinoic acid receptor RXR-alpha RXRA Tclin Nuclear Receptor -2.48285 237.9 299
Coagulation factor XIII B chain F13B Tbio Non-IDG -2.20763 157.9 115