Development Level

Tchem 41 | 1,598
Tbio 20 | 11,445
Tclin 8 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 6 | 979
decreased body weight 3 | 161
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal gait 2 | 69
abnormal retina morphology 2 | 71
decreased circulating creatini... 2 | 39
decreased total body fat amoun... 2 | 207
increased circulating glucose ... 2 | 24
increased neutrophil cell numb... 2 | 46
short tibia 2 | 97
abnormal clavicle morphology 1 | 6
abnormal coat appearance 1 | 31
abnormal cranium morphology 1 | 36
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal startle reflex 1 | 15
cataract 1 | 92
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
hypoactivity 1 | 132
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
prenatal lethality 1 | 28

Disease

Carcinoma 60 | 11,493
ovarian cancer 52 | 8,520
Cancer 50 | 2,499
osteosarcoma 44 | 7,950
glioblastoma 42 | 5,792
atypical teratoid / rhabdoid tumor 37 | 5,112
medulloblastoma, large-cell 36 | 6,241
lung cancer 35 | 4,740
psoriasis 32 | 6,694
ependymoma 30 | 4,679
adult high grade glioma 29 | 3,801
Breast cancer 23 | 3,578
Kidney cancer 23 | 2,613
Astrocytoma, Pilocytic 21 | 3,081
subependymal giant cell astrocytoma 21 | 2,287
group 3 medulloblastoma 20 | 4,104
malignant mesothelioma 19 | 3,232
group 4 medulloblastoma 18 | 1,855
pancreatic cancer 18 | 2,398
Schizophrenia 17 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
Intellectual disability 15 | 1,016
Vascular disease 15 | 319
invasive ductal carcinoma 15 | 2,951
juvenile dermatomyositis 15 | 1,187
oligodendroglioma 15 | 2,850
Byzanthine arch palate 14 | 194
Orbital separation excessive 14 | 244
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
primitive neuroectodermal tumor 14 | 3,035
Dull intelligence 13 | 645
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental deficiency 13 | 645
Multiple myeloma 13 | 1,332
Poor school performance 13 | 645
Short stature 13 | 531
astrocytic glioma 13 | 2,597
lung carcinoma 13 | 2,843
pituitary cancer 13 | 1,972
tuberculosis 13 | 2,010
Acquired scoliosis 12 | 281
Breast Neoplasms 12 | 445
Curvature of spine 12 | 282
Downward slant of palpebral fissure 12 | 158
Mammary Neoplasms 12 | 425
Rheumatoid arthritis 12 | 1,191
diabetes mellitus 12 | 1,728
Concave bridge of nose 11 | 195
Depressed nasal bridge 11 | 195
Depressed nasal root/bridge 11 | 195
Epilepsy 11 | 792
Lung Neoplasms 11 | 232
Muscle hypotonia 11 | 571
Pectus excavatum 11 | 100
Stomach Neoplasms 11 | 300
astrocytoma 11 | 1,146
cystic fibrosis 11 | 1,696
Blepharoptosis 10 | 231
Cryptorchidism 10 | 296
High forehead 10 | 102
Hypoplastic mandible condyle 10 | 275
Joint hyperflexibility 10 | 78
Mandibular hypoplasia 10 | 275
Micrognathism 10 | 275
Neoplasm Metastasis 10 | 168
Noonan syndrome 10 | 34
Seizures 10 | 596
Tall forehead 10 | 102
breast carcinoma 10 | 1,638
non-small cell lung cancer 10 | 2,890
ulcerative colitis 10 | 1,819
Alzheimer's disease 9 | 658
Big calvaria 9 | 147
Cognitive delay 9 | 608
Congenital Epicanthus 9 | 177
Delayed bone age 9 | 136
Depressive disorder 9 | 409
Feeding difficulties in infancy 9 | 175
Frontal bossing 9 | 157
Global developmental delay 9 | 608
Heart disease 9 | 306
Increased head circumference 9 | 147
Increased size of cranium 9 | 147
Increased size of skull 9 | 147
Mental and motor retardation 9 | 608
Neck webbing 9 | 35
Renal Cell Carcinoma 9 | 214
Strabismus 9 | 270
colon cancer 9 | 1,478
interstitial cystitis 9 | 2,312
primary pancreatic ductal adenocarcinoma 9 | 1,109
Arthritis 8 | 290
Low-set, posteriorly rotated ears 8 | 110
Pick disease 8 | 1,894
Short neck 8 | 140
Waldenstrons macroglobulinemia 8 | 765
dermatomyositis 8 | 966
pancreatic carcinoma 8 | 562

Tissue

Blood and immune system 70 | 16,909
Cardiovascular System 70 | 15,192
Digestive Tract 70 | 17,369
Endocrine System 70 | 18,159
Female tissues 70 | 17,400
Liver and Pancreas 70 | 16,750
Male tissues 70 | 17,142
Nervous System 70 | 16,725
Respiratory system 70 | 16,393
Skin and soft tissues 70 | 17,230
Urinary Tract 70 | 16,678

Target Family

Kinase 39 | 634
Enzyme 14 | 4,145
Non-IDG 10 | 12,091
Transcription Factor 7 | 1,400

PathwayCommons: panther Pathway

http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 264 | 264
http://identifiers.org/panther... 197 | 197
http://identifiers.org/panther... 164 | 164
http://identifiers.org/panther... 151 | 151
http://identifiers.org/panther... 150 | 150
http://identifiers.org/panther... 149 | 149
http://identifiers.org/panther... 146 | 146
http://identifiers.org/panther... 124 | 124
http://identifiers.org/panther... 118 | 118
http://identifiers.org/panther... 116 | 116
http://identifiers.org/panther... 115 | 115
http://identifiers.org/panther... 110 | 110
http://identifiers.org/panther... 107 | 107
http://identifiers.org/panther... 104 | 104
http://identifiers.org/panther... 91 | 91
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 86 | 86
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 67 | 67
http://identifiers.org/panther... 65 | 65
http://identifiers.org/panther... 63 | 63
http://identifiers.org/panther... 61 | 61
http://identifiers.org/panther... 60 | 60
http://identifiers.org/panther... 56 | 56
http://identifiers.org/panther... 54 | 54
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 51 | 51
http://identifiers.org/panther... 47 | 47
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 44 | 44
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 41 | 41
http://identifiers.org/panther... 38 | 38
http://identifiers.org/panther... 37 | 37
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 33 | 33
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 31 | 31
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 27 | 27
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 17 | 17
http://identifiers.org/panther... 16 | 16
http://identifiers.org/panther... 15 | 15
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 13 | 13
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 8 | 8
http://identifiers.org/panther... 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
RAC-alpha serine/threonine-protein kinase AKT1 Tchem Kinase -4.36734 20160.1 3565
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.81500 6459.7 1749
Transcription factor AP-1 JUN Tchem Transcription Factor -3.83935 6236.4 2664
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
Mitogen-activated protein kinase 8 MAPK8 Tchem Kinase -3.81256 5770.8 1150
Dual specificity mitogen-activated protein kinase kinase 7 MAP2K7 Tchem Kinase -3.66356 3766.3 513
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440
Transforming protein RhoA RHOA Tbio Enzyme -3.54095 3332.7 501
Mitogen-activated protein kinase 14 MAPK14 Tchem Kinase -3.36007 2240.8 1574