Development Level

Tbio 7 | 11,445
Tchem 3 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal embryo size 1 | 220
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal vitreous body morphol... 1 | 10
decreased blood urea nitrogen ... 1 | 51
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
preweaning lethality, incomple... 1 | 499
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74
small thymus 1 | 16

Disease

Carcinoma 8 | 11,493
osteosarcoma 8 | 7,950
Porphyria 6 | 10
Hereditary coproporphyria 5 | 8
Variegate Porphyria 5 | 10
lung cancer 5 | 4,740
ovarian cancer 5 | 8,520
Abdominal Pain 4 | 98
Acute intermittent porphyria 4 | 15
Autosomal recessive predisposition 4 | 1,442
Constipation 4 | 181
Dyschezia 4 | 135
Epilepsy 4 | 792
Photosensitivity of skin 4 | 51
Porphyria cutanea tarda 4 | 12
Vomiting 4 | 116
malignant mesothelioma 4 | 3,232
medulloblastoma, large-cell 4 | 6,241
psoriasis 4 | 6,694
Anemia 3 | 365
Anemia, Hemolytic 3 | 55
Diarrhea 3 | 253
Elevated heart rate 3 | 25
Erythropoietic protoporphyria 3 | 15
Hypertensive disease 3 | 292
Muscle hypotonia 3 | 571
Peripheral Neuropathy 3 | 134
Respiratory Paralysis 3 | 7
Seizures 3 | 596
Tachycardia 3 | 43
Thin skin 3 | 47
atypical teratoid / rhabdoid tumor 3 | 5,112
ependymoma 3 | 4,679
glioblastoma 3 | 5,792
group 3 medulloblastoma 3 | 4,104
oligodendroglioma 3 | 2,850
Abnormal blistering of the skin 2 | 54
Acute episodes of neuropathic symptoms 2 | 2
Anxiety 2 | 136
Anxiety disease 2 | 113
Blister of skin 2 | 54
Cancer 2 | 2,499
Cognitive delay 2 | 608
Cutaneous porphyria 2 | 6
Depressive disorder 2 | 409
Elevated urinary delta-aminolevulinic acid 2 | 3
Failure to gain weight 2 | 365
Global developmental delay 2 | 608
Hepatomegaly 2 | 285
Hypertrichosis 2 | 46
Increase in blood pressure 2 | 119
Increased hepatocellular carcinoma risk 2 | 27
Increased incidence of hepatocellular carcinoma 2 | 27
Intellectual disability 2 | 1,016
Kidney cancer 2 | 2,613
Leigh disease 2 | 100
Liver Cirrhosis 2 | 181
Liver carcinoma 2 | 240
Mental and motor retardation 2 | 608
Microcephaly 2 | 166
Multiple myeloma 2 | 1,332
Myalgia 2 | 54
Nausea and vomiting 2 | 97
Neuropathy 2 | 261
Paresthesia 2 | 32
Pediatric failure to thrive 2 | 365
Progressive disorder 2 | 142
Prostatic Neoplasms 2 | 495
Psychotic Disorders 2 | 151
Skin bulla 2 | 54
Sleeplessness 2 | 16
Waldenstrons macroglobulinemia 2 | 765
astrocytic glioma 2 | 2,597
astrocytoma 2 | 1,146
cutaneous lupus erythematosus 2 | 1,057
group 4 medulloblastoma 2 | 1,855
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
non-small cell lung cancer 2 | 2,890
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primitive neuroectodermal tumor 2 | 3,035
tuberculosis 2 | 2,010
Abnormal respiratory patterns 1 | 20
Abnormal urinary amino-acid findings 1 | 38
Aminoaciduria 1 | 38
Anorexia 1 | 43
Autosomal recessive nonsyndromic deafness 98 1 | 4
Confusion 1 | 21
Fragile skin 1 | 18
Head and Neck Neoplasms 1 | 26
Hepatocellular necrosis 1 | 14
Hyperpigmented macules 1 | 42
Hypertriglyceridemia result 1 | 37
Increased intramyocellular lipid droplets 1 | 13
Inverted follicular keratosis 1 | 3
Leigh syndrome 1 | 28
Meningioma 1 | 41
Progressive microcephaly 1 | 32
Tyrosinemia 1 | 10

Tissue

Blood and immune system 11 | 16,909
Cardiovascular System 11 | 15,192
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Male tissues 11 | 17,142
Nervous System 11 | 16,725
Respiratory system 11 | 16,393
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678

Target Family

Enzyme 10 | 4,145
Non-IDG 1 | 12,091

PathwayCommons: panther Pathway

http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 264 | 264
http://identifiers.org/panther... 197 | 197
http://identifiers.org/panther... 164 | 164
http://identifiers.org/panther... 151 | 151
http://identifiers.org/panther... 150 | 150
http://identifiers.org/panther... 149 | 149
http://identifiers.org/panther... 146 | 146
http://identifiers.org/panther... 124 | 124
http://identifiers.org/panther... 118 | 118
http://identifiers.org/panther... 116 | 116
http://identifiers.org/panther... 115 | 115
http://identifiers.org/panther... 110 | 110
http://identifiers.org/panther... 107 | 107
http://identifiers.org/panther... 104 | 104
http://identifiers.org/panther... 91 | 91
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 86 | 86
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 67 | 67
http://identifiers.org/panther... 65 | 65
http://identifiers.org/panther... 63 | 63
http://identifiers.org/panther... 61 | 61
http://identifiers.org/panther... 60 | 60
http://identifiers.org/panther... 56 | 56
http://identifiers.org/panther... 54 | 54
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 51 | 51
http://identifiers.org/panther... 47 | 47
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 44 | 44
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 41 | 41
http://identifiers.org/panther... 38 | 38
http://identifiers.org/panther... 37 | 37
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 33 | 33
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 31 | 31
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 27 | 27
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 17 | 17
http://identifiers.org/panther... 16 | 16
http://identifiers.org/panther... 15 | 15
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 13 | 13
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 8 | 8
http://identifiers.org/panther... 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protoheme IX farnesyltransferase, mitochondrial COX10 Tbio Enzyme -1.60266 40.9 154
Porphobilinogen deaminase HMBS Tbio Enzyme -2.78202 588.5 255
Protoporphyrinogen oxidase PPOX Tchem Enzyme -2.47389 296.8 173
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial CPOX Tbio Enzyme -2.05504 112.4 87
Delta-aminolevulinic acid dehydratase ALAD Tbio Enzyme -3.02024 1068.6 166
Probable glutamate--tRNA ligase, mitochondrial EARS2 Tbio Enzyme -2.39134 243.3 69
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial RSAD1 Tdark Non-IDG -0.05115 1.13 101
Bifunctional glutamate/proline--tRNA ligase EPRS Tchem Enzyme -3.11686 1267.4 98
Glutamine--tRNA ligase QARS Tchem Enzyme -1.63877 42.2 77
Ferrochelatase, mitochondrial FECH Tbio Enzyme -2.73759 528.2 136