Development Level

Tchem 36 | 1,598
Tbio 16 | 11,445
Tclin 9 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

decreased body weight 4 | 161
preweaning lethality, complete... 4 | 979
decreased circulating creatini... 2 | 39
increased circulating glucose ... 2 | 24
increased circulating iron lev... 2 | 30
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal testis morphology 1 | 43
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mature B cell number 1 | 7
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
improved glucose tolerance 1 | 79
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased body length 1 | 32
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating glycerol... 1 | 9
increased erythrocyte cell num... 1 | 39
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
shortened RR interval 1 | 17
small testis 1 | 58

Disease

Carcinoma 48 | 11,493
ovarian cancer 39 | 8,520
Cancer 37 | 2,499
glioblastoma 35 | 5,792
osteosarcoma 34 | 7,950
lung cancer 30 | 4,740
psoriasis 27 | 6,694
ependymoma 25 | 4,679
medulloblastoma, large-cell 25 | 6,241
atypical teratoid / rhabdoid tumor 23 | 5,112
invasive ductal carcinoma 20 | 2,951
Breast cancer 19 | 3,578
Kidney cancer 19 | 2,613
adult high grade glioma 18 | 3,801
Schizophrenia 16 | 1,160
group 3 medulloblastoma 16 | 4,104
oligodendroglioma 16 | 2,850
lung adenocarcinoma 15 | 2,716
malignant mesothelioma 15 | 3,232
primitive neuroectodermal tumor 15 | 3,035
Astrocytoma, Pilocytic 14 | 3,081
interstitial cystitis 14 | 2,312
subependymal giant cell astrocytoma 14 | 2,287
ulcerative colitis 14 | 1,819
astrocytic glioma 12 | 2,597
diabetes mellitus 12 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
juvenile dermatomyositis 12 | 1,187
pancreatic cancer 12 | 2,398
tuberculosis 12 | 2,010
Prostatic Neoplasms 11 | 495
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
lung carcinoma 11 | 2,843
non-small cell lung cancer 11 | 2,890
Bipolar Disorder 10 | 666
Intellectual disability 10 | 1,016
astrocytoma 10 | 1,146
cystic fibrosis 10 | 1,696
ductal carcinoma in situ 10 | 1,745
primary Sjogren syndrome 10 | 735
Breast Neoplasms 9 | 445
Carcinoma, Squamous Cell 9 | 110
Cognitive delay 9 | 608
Global developmental delay 9 | 608
Heart disease 9 | 306
Mammary Neoplasms 9 | 425
Melanoma 9 | 711
Mental and motor retardation 9 | 608
Orbital separation excessive 9 | 244
Renal Cell Carcinoma 9 | 214
Rheumatoid arthritis 9 | 1,191
Squamous cell carcinoma 9 | 129
Stomach Neoplasms 9 | 300
Vascular disease 9 | 319
breast carcinoma 9 | 1,638
colon cancer 9 | 1,478
group 4 medulloblastoma 9 | 1,855
pediatric high grade glioma 9 | 1,064
Blepharoptosis 8 | 231
Byzanthine arch palate 8 | 194
Colorectal Neoplasms 8 | 243
Concave bridge of nose 8 | 195
Depressed nasal bridge 8 | 195
Depressed nasal root/bridge 8 | 195
Depressive disorder 8 | 409
Downward slant of palpebral fissure 8 | 158
Dull intelligence 8 | 645
Epilepsy 8 | 792
Frontal bossing 8 | 157
Hypoplastic mandible condyle 8 | 275
Liver Cirrhosis, Experimental 8 | 769
Low intelligence 8 | 645
Lung Neoplasms 8 | 232
Mandibular hypoplasia 8 | 275
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Micrognathism 8 | 275
Myopia 8 | 176
Poor school performance 8 | 645
Seizures 8 | 596
dermatomyositis 8 | 966
pituitary cancer 8 | 1,972
Acquired scoliosis 7 | 281
Big calvaria 7 | 147
Curvature of spine 7 | 282
High forehead 7 | 102
Hypertrophic Cardiomyopathy 7 | 117
Increased head circumference 7 | 147
Increased size of cranium 7 | 147
Increased size of skull 7 | 147
Mental Depression 7 | 333
Multiple myeloma 7 | 1,332
Muscle hypotonia 7 | 571
Pectus excavatum 7 | 100
Pick disease 7 | 1,894
Short stature 7 | 531
Strabismus 7 | 270
Tall forehead 7 | 102
Waldenstrons macroglobulinemia 7 | 765

Tissue

Digestive Tract 61 | 17,369
Liver and Pancreas 61 | 16,750
Blood and immune system 60 | 16,909
Endocrine System 60 | 18,159
Female tissues 60 | 17,400
Male tissues 60 | 17,142
Nervous System 60 | 16,725
Skin and soft tissues 60 | 17,230
Urinary Tract 60 | 16,678
Respiratory system 59 | 16,393
Cardiovascular System 58 | 15,192

Target Family

Kinase 35 | 634
Enzyme 14 | 4,145
Non-IDG 10 | 12,091
Transcription Factor 2 | 1,400

PathwayCommons: panther Pathway

http://identifiers.org/panther... 61 | 61
http://identifiers.org/panther... 264 | 264
http://identifiers.org/panther... 197 | 197
http://identifiers.org/panther... 164 | 164
http://identifiers.org/panther... 151 | 151
http://identifiers.org/panther... 150 | 150
http://identifiers.org/panther... 149 | 149
http://identifiers.org/panther... 146 | 146
http://identifiers.org/panther... 124 | 124
http://identifiers.org/panther... 118 | 118
http://identifiers.org/panther... 116 | 116
http://identifiers.org/panther... 115 | 115
http://identifiers.org/panther... 110 | 110
http://identifiers.org/panther... 107 | 107
http://identifiers.org/panther... 104 | 104
http://identifiers.org/panther... 91 | 91
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 86 | 86
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 67 | 67
http://identifiers.org/panther... 65 | 65
http://identifiers.org/panther... 63 | 63
http://identifiers.org/panther... 60 | 60
http://identifiers.org/panther... 56 | 56
http://identifiers.org/panther... 54 | 54
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 51 | 51
http://identifiers.org/panther... 47 | 47
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 44 | 44
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 41 | 41
http://identifiers.org/panther... 38 | 38
http://identifiers.org/panther... 37 | 37
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 33 | 33
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 31 | 31
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 27 | 27
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 17 | 17
http://identifiers.org/panther... 16 | 16
http://identifiers.org/panther... 15 | 15
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 13 | 13
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 8 | 8
http://identifiers.org/panther... 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
Heat shock protein beta-1 HSPB1 Tchem Non-IDG -2.97780 974.9 1992
Serine/threonine-protein kinase D3 PRKD3 Tchem Kinase -1.23218 13.2 295
Serine/threonine-protein kinase D2 PRKD2 Tchem Kinase -1.46203 23.4 417
Transforming growth factor beta-1-induced transcript 1 protein TGFB1I1 Tbio Non-IDG -1.82580 89.7 147
SHC-transforming protein 2 SHC2 Tbio Non-IDG -2.47843 293.4 113