Development Level

Tchem 31 | 1,598
Tbio 17 | 11,445
Tclin 12 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased body weight 4 | 161
preweaning lethality, incomple... 4 | 499
abnormal lens morphology 2 | 81
abnormal retina morphology 2 | 71
cataract 2 | 92
decreased circulating creatini... 2 | 39
embryonic lethality prior to t... 2 | 278
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
decreased T cell number 1 | 15
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged kidney 1 | 14
increased CD4-positive, alpha ... 1 | 4
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prenatal lethality 1 | 28
small epididymis 1 | 3
small testis 1 | 58
thin ventricular wall 1 | 24
thrombocytosis 1 | 27

Disease

Carcinoma 52 | 11,493
ovarian cancer 46 | 8,520
Cancer 41 | 2,499
osteosarcoma 38 | 7,950
lung cancer 34 | 4,740
glioblastoma 31 | 5,792
psoriasis 30 | 6,694
medulloblastoma, large-cell 23 | 6,241
Breast cancer 21 | 3,578
atypical teratoid / rhabdoid tumor 20 | 5,112
Kidney cancer 19 | 2,613
ependymoma 19 | 4,679
lung carcinoma 19 | 2,843
adult high grade glioma 18 | 3,801
Astrocytoma, Pilocytic 17 | 3,081
interstitial cystitis 17 | 2,312
subependymal giant cell astrocytoma 17 | 2,287
cutaneous lupus erythematosus 16 | 1,057
group 3 medulloblastoma 16 | 4,104
invasive ductal carcinoma 15 | 2,951
oligodendroglioma 15 | 2,850
Autosomal recessive predisposition 14 | 1,442
Rheumatoid arthritis 14 | 1,191
Schizophrenia 14 | 1,160
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
Intellectual disability 13 | 1,016
astrocytic glioma 13 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
malignant mesothelioma 13 | 3,232
primitive neuroectodermal tumor 13 | 3,035
Dull intelligence 12 | 645
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Orbital separation excessive 12 | 244
Poor school performance 12 | 645
diabetes mellitus 12 | 1,728
non-small cell lung cancer 12 | 2,890
Arthritis 11 | 290
Breast Neoplasms 11 | 445
Byzanthine arch palate 11 | 194
Epilepsy 11 | 792
Immunologic Deficiency Syndromes 11 | 113
Mammary Neoplasms 11 | 425
Pick disease 11 | 1,894
Seizures 11 | 596
Waldenstrons macroglobulinemia 11 | 765
group 4 medulloblastoma 11 | 1,855
pancreatic cancer 11 | 2,398
ulcerative colitis 11 | 1,819
Blepharoptosis 10 | 231
Cognitive delay 10 | 608
Concave bridge of nose 10 | 195
Depressed nasal bridge 10 | 195
Depressed nasal root/bridge 10 | 195
Downward slant of palpebral fissure 10 | 158
Global developmental delay 10 | 608
Hepatomegaly 10 | 285
High forehead 10 | 102
Hypoplastic mandible condyle 10 | 275
Mandibular hypoplasia 10 | 275
Mental and motor retardation 10 | 608
Micrognathism 10 | 275
Muscle hypotonia 10 | 571
Tall forehead 10 | 102
cystic fibrosis 10 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
juvenile dermatomyositis 10 | 1,187
Acquired scoliosis 9 | 281
Big calvaria 9 | 147
Cryptorchidism 9 | 296
Curvature of spine 9 | 282
Failure to gain weight 9 | 365
Frontal bossing 9 | 157
Increased head circumference 9 | 147
Increased size of cranium 9 | 147
Increased size of skull 9 | 147
Lung Neoplasms 9 | 232
Multiple myeloma 9 | 1,332
Pectus excavatum 9 | 100
Pediatric failure to thrive 9 | 365
Renal Cell Carcinoma 9 | 214
Short stature 9 | 531
Vascular disease 9 | 319
colon cancer 9 | 1,478
lung adenocarcinoma 9 | 2,716
tuberculosis 9 | 2,010
Melanoma 8 | 711
Neck webbing 8 | 35
Noonan syndrome 8 | 34
Obesity 8 | 678
Prostatic Neoplasms 8 | 495
Splenomegaly 8 | 190
Stomach Neoplasms 8 | 300
Strabismus 8 | 270
breast carcinoma 8 | 1,638
pituitary cancer 8 | 1,972
Asthma 7 | 385
Bipolar Disorder 7 | 666
primary Sjogren syndrome 7 | 735

Tissue

Blood and immune system 60 | 16,909
Digestive Tract 60 | 17,369
Endocrine System 60 | 18,159
Female tissues 60 | 17,400
Liver and Pancreas 60 | 16,750
Male tissues 60 | 17,142
Nervous System 60 | 16,725
Respiratory system 60 | 16,393
Skin and soft tissues 60 | 17,230
Urinary Tract 60 | 16,678
Cardiovascular System 59 | 15,192

Target Family

Kinase 28 | 634
Non-IDG 18 | 12,091
Enzyme 11 | 4,145
Transcription Factor 2 | 1,400
Ion Channel 1 | 344

PathwayCommons: panther Pathway

http://identifiers.org/panther... 60 | 60
http://identifiers.org/panther... 264 | 264
http://identifiers.org/panther... 197 | 197
http://identifiers.org/panther... 164 | 164
http://identifiers.org/panther... 151 | 151
http://identifiers.org/panther... 150 | 150
http://identifiers.org/panther... 149 | 149
http://identifiers.org/panther... 146 | 146
http://identifiers.org/panther... 124 | 124
http://identifiers.org/panther... 118 | 118
http://identifiers.org/panther... 116 | 116
http://identifiers.org/panther... 115 | 115
http://identifiers.org/panther... 110 | 110
http://identifiers.org/panther... 107 | 107
http://identifiers.org/panther... 104 | 104
http://identifiers.org/panther... 91 | 91
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 86 | 86
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 67 | 67
http://identifiers.org/panther... 65 | 65
http://identifiers.org/panther... 63 | 63
http://identifiers.org/panther... 61 | 61
http://identifiers.org/panther... 56 | 56
http://identifiers.org/panther... 54 | 54
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 51 | 51
http://identifiers.org/panther... 47 | 47
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 44 | 44
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 41 | 41
http://identifiers.org/panther... 38 | 38
http://identifiers.org/panther... 37 | 37
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 33 | 33
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 31 | 31
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 27 | 27
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 17 | 17
http://identifiers.org/panther... 16 | 16
http://identifiers.org/panther... 15 | 15
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 13 | 13
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 8 | 8
http://identifiers.org/panther... 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform PPP3CB Tbio Enzyme -1.53531 28.2 147
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Linker for activation of T-cells family member 1 LAT Tbio Non-IDG -2.16291 169.4 667
Son of sevenless homolog 2 SOS2 Tbio Non-IDG -1.62118 35.9 134
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
T-cell surface glycoprotein CD3 gamma chain CD3G Tclin Non-IDG -2.34430 223.5 239
Serine/threonine-protein kinase PAK 3 PAK3 Tchem Kinase -1.35059 21.1 377
Mitogen-activated protein kinase kinase kinase 1 MAP3K1 Tchem Kinase -2.12399 119.4 334