Development Level

Tbio 60 | 11,445
Tchem 28 | 1,598
Tdark 2 | 6,588
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 11 | 979
embryonic lethality prior to t... 4 | 278
abnormal embryo size 3 | 220
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
decreased startle reflex 2 | 75
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
hypoactivity 2 | 132
prenatal lethality 2 | 28
abnormal behavior 1 | 298
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal eyelid morphology 1 | 7
abnormal gait 1 | 69
abnormal head size 1 | 6
abnormal iris morphology 1 | 13
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal placement of pupils 1 | 6
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased B cell number 1 | 5
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased circulating creatini... 1 | 39
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
edema 1 | 59
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased circulating HDL chol... 1 | 80
increased circulating glucose ... 1 | 24
increased circulating potassiu... 1 | 29
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
irregularly shaped pupil 1 | 7
microphthalmia 1 | 26
narrow eye opening 1 | 12
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytopenia 1 | 56
trunk curl 1 | 16

Disease

Carcinoma 60 | 11,493
ovarian cancer 51 | 8,520
osteosarcoma 44 | 7,950
glioblastoma 41 | 5,792
Cancer 40 | 2,499
psoriasis 38 | 6,694
atypical teratoid / rhabdoid tumor 33 | 5,112
lung cancer 32 | 4,740
medulloblastoma, large-cell 30 | 6,241
group 3 medulloblastoma 25 | 4,104
ependymoma 24 | 4,679
adult high grade glioma 23 | 3,801
Astrocytoma, Pilocytic 22 | 3,081
Breast cancer 22 | 3,578
lung carcinoma 22 | 2,843
malignant mesothelioma 19 | 3,232
group 4 medulloblastoma 18 | 1,855
invasive ductal carcinoma 18 | 2,951
lung adenocarcinoma 18 | 2,716
non-small cell lung cancer 18 | 2,890
Kidney cancer 17 | 2,613
interstitial cystitis 16 | 2,312
breast carcinoma 15 | 1,638
oligodendroglioma 14 | 2,850
Schizophrenia 13 | 1,160
cystic fibrosis 13 | 1,696
ductal carcinoma in situ 13 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
juvenile dermatomyositis 13 | 1,187
pancreatic cancer 13 | 2,398
subependymal giant cell astrocytoma 13 | 2,287
tuberculosis 13 | 2,010
Acquired scoliosis 12 | 281
Curvature of spine 12 | 282
Pick disease 12 | 1,894
Short stature 12 | 531
diabetes mellitus 12 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
primitive neuroectodermal tumor 12 | 3,035
Orbital separation excessive 11 | 244
Stomach Neoplasms 11 | 300
astrocytic glioma 11 | 2,597
colon cancer 11 | 1,478
Acquired flat foot 10 | 72
Bilateral fifth finger clinodactyly 10 | 110
Byzanthine arch palate 10 | 194
Curvature of little finger 10 | 110
Epilepsy 10 | 792
Flatfoot 10 | 73
Vascular disease 10 | 319
astrocytoma 10 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
pediatric high grade glioma 10 | 1,064
Brachydactyly 9 | 156
Craniofacial Abnormalities 9 | 151
Cryptorchidism 9 | 296
Downward slant of palpebral fissure 9 | 158
Fibrodysplasia ossificans progressiva 9 | 17
Heart disease 9 | 306
Hypertensive disease 9 | 292
Hypoplastic mandible condyle 9 | 275
Liver Cirrhosis, Experimental 9 | 769
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
Osteoarthritis 9 | 184
acute myeloid leukemia 9 | 783
acute quadriplegic myopathy 9 | 1,158
pituitary cancer 9 | 1,972
ulcerative colitis 9 | 1,819
Breast Neoplasms 8 | 445
Dull intelligence 8 | 645
Exophthalmos 8 | 112
Increase in blood pressure 8 | 119
Intellectual disability 8 | 1,016
Low intelligence 8 | 645
Lung Neoplasms 8 | 232
Mammary Neoplasms 8 | 425
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Prominent eyes 8 | 96
Prominent globes 8 | 96
Prostatic Neoplasms 8 | 495
Protruding eyes 8 | 96
Rheumatoid arthritis 8 | 1,191
Right atrial isomerism 8 | 29
Seizures 8 | 596
Atrial Septal Defects 7 | 85
Autosomal recessive predisposition 7 | 1,442
Cleft Palate 7 | 271
Congenital heart disease 7 | 93
Kidney disease 7 | 430
Muscle hypotonia 7 | 571
Polycystic ovary syndrome 7 | 360
Ventricular Septal Defects 7 | 119
active Crohn's disease 7 | 922
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
gastric cancer 7 | 459
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
primary pancreatic ductal adenocarcinoma 7 | 1,109

Tissue

Endocrine System 91 | 18,159
Female tissues 89 | 17,400
Liver and Pancreas 89 | 16,750
Digestive Tract 88 | 17,369
Male tissues 87 | 17,142
Skin and soft tissues 87 | 17,230
Nervous System 86 | 16,725
Urinary Tract 86 | 16,678
Blood and immune system 84 | 16,909
Cardiovascular System 84 | 15,192
Respiratory system 83 | 16,393

Target Family

Non-IDG 44 | 12,091
Kinase 23 | 634
Transcription Factor 14 | 1,400
Enzyme 8 | 4,145
Epigenetic 2 | 242

PathwayCommons: panther Pathway

http://identifiers.org/panther... 91 | 91
http://identifiers.org/panther... 264 | 264
http://identifiers.org/panther... 197 | 197
http://identifiers.org/panther... 164 | 164
http://identifiers.org/panther... 151 | 151
http://identifiers.org/panther... 150 | 150
http://identifiers.org/panther... 149 | 149
http://identifiers.org/panther... 146 | 146
http://identifiers.org/panther... 124 | 124
http://identifiers.org/panther... 118 | 118
http://identifiers.org/panther... 116 | 116
http://identifiers.org/panther... 115 | 115
http://identifiers.org/panther... 110 | 110
http://identifiers.org/panther... 107 | 107
http://identifiers.org/panther... 104 | 104
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 86 | 86
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 67 | 67
http://identifiers.org/panther... 65 | 65
http://identifiers.org/panther... 63 | 63
http://identifiers.org/panther... 61 | 61
http://identifiers.org/panther... 60 | 60
http://identifiers.org/panther... 56 | 56
http://identifiers.org/panther... 54 | 54
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 51 | 51
http://identifiers.org/panther... 47 | 47
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 44 | 44
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 41 | 41
http://identifiers.org/panther... 38 | 38
http://identifiers.org/panther... 37 | 37
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 33 | 33
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 31 | 31
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 27 | 27
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 17 | 17
http://identifiers.org/panther... 16 | 16
http://identifiers.org/panther... 15 | 15
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 13 | 13
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 8 | 8
http://identifiers.org/panther... 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Growth/differentiation factor 15 GDF15 Tbio Non-IDG -2.84344 761.3 702
Growth/differentiation factor 2 GDF2 Tbio Non-IDG -2.16825 176.4 239
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Peptidyl-prolyl cis-trans isomerase FKBP2 FKBP2 Tbio Enzyme -1.93669 75.0 72
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Mothers against decapentaplegic homolog 6 SMAD6 Tbio Transcription Factor -2.07569 106.7 450
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.66587 458.1 390
Embryonic growth/differentiation factor 1 GDF1 Tbio Non-IDG -2.00590 102.6 64
Tolloid-like protein 1 TLL1 Tbio Non-IDG -1.44490 24.3 83