Development Level

Tbio 61 | 11,445
Tchem 46 | 1,598
Tclin 13 | 613
Tdark 4 | 6,588

Collection

Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 9 | 979
decreased body weight 7 | 161
decreased circulating triglyce... 4 | 79
preweaning lethality, incomple... 4 | 499
abnormal bone mineralization 3 | 38
abnormal bone structure 3 | 187
decreased circulating choleste... 3 | 93
increased erythrocyte cell num... 3 | 39
increased total body fat amoun... 3 | 134
abnormal embryo size 2 | 220
abnormal gait 2 | 69
decreased bone mineral density 2 | 126
decreased circulating creatini... 2 | 39
decreased circulating glycerol... 2 | 16
decreased circulating serum al... 2 | 82
decreased erythrocyte cell num... 2 | 62
decreased grip strength 2 | 116
decreased hematocrit 2 | 46
decreased lean body mass 2 | 135
decreased mature B cell number 2 | 7
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased T cell number 2 | 6
increased circulating alkaline... 2 | 122
increased circulating glucose ... 2 | 24
increased lean body mass 2 | 172
increased neutrophil cell numb... 2 | 46
prenatal lethality prior to he... 2 | 87
abnormal behavioral response t... 1 | 66
abnormal clavicle morphology 1 | 6
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal digit morphology 1 | 10
abnormal ear morphology 1 | 9
abnormal facial morphology 1 | 17
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased IgG3 level 1 | 1
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating chloride... 1 | 30
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased circulating unsatura... 1 | 2
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
impaired righting response 1 | 26
increased B cell number 1 | 9
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
small epididymis 1 | 3
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
urinary bladder obstruction 1 | 4

Disease

Carcinoma 101 | 11,493
ovarian cancer 78 | 8,520
osteosarcoma 76 | 7,950
Cancer 65 | 2,499
lung cancer 53 | 4,740
glioblastoma 51 | 5,792
medulloblastoma, large-cell 50 | 6,241
psoriasis 50 | 6,694
Breast cancer 42 | 3,578
atypical teratoid / rhabdoid tumor 41 | 5,112
Kidney cancer 38 | 2,613
ependymoma 37 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,291
invasive ductal carcinoma 34 | 2,951
malignant mesothelioma 33 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 32 | 2,989
subependymal giant cell astrocytoma 30 | 2,287
Astrocytoma, Pilocytic 29 | 3,081
group 3 medulloblastoma 29 | 4,104
group 4 medulloblastoma 29 | 1,855
lung carcinoma 29 | 2,843
pancreatic cancer 29 | 2,398
adult high grade glioma 28 | 3,801
primitive neuroectodermal tumor 27 | 3,035
non-small cell lung cancer 24 | 2,890
ulcerative colitis 24 | 1,819
tuberculosis 23 | 2,010
astrocytic glioma 22 | 2,597
interstitial cystitis 22 | 2,312
lung adenocarcinoma 22 | 2,716
oligodendroglioma 22 | 2,850
pituitary cancer 21 | 1,972
Rheumatoid arthritis 20 | 1,191
Pick disease 19 | 1,894
cystic fibrosis 19 | 1,696
Schizophrenia 18 | 1,160
juvenile dermatomyositis 18 | 1,187
diabetes mellitus 17 | 1,728
spina bifida 17 | 1,074
Intellectual disability 16 | 1,016
astrocytoma 16 | 1,146
primary Sjogren syndrome 16 | 735
Multiple myeloma 15 | 1,332
Muscle hypotonia 15 | 571
Orbital separation excessive 15 | 244
ductal carcinoma in situ 15 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
Epilepsy 14 | 792
Obesity 14 | 678
Short stature 14 | 531
breast carcinoma 14 | 1,638
Autosomal recessive predisposition 13 | 1,442
Blepharoptosis 13 | 231
Breast Neoplasms 13 | 445
Downward slant of palpebral fissure 13 | 158
Dull intelligence 13 | 645
Frontal bossing 13 | 157
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental deficiency 13 | 645
Poor school performance 13 | 645
Seizures 13 | 596
Vascular disease 13 | 319
Acquired scoliosis 12 | 281
Byzanthine arch palate 12 | 194
Curvature of spine 12 | 282
Delayed bone age 12 | 136
Hepatomegaly 12 | 285
High forehead 12 | 102
Mammary Neoplasms 12 | 425
Prostatic Neoplasms 12 | 495
Strabismus 12 | 270
Tall forehead 12 | 102
acute myeloid leukemia 12 | 783
primary pancreatic ductal adenocarcinoma 12 | 1,109
Arthritis 11 | 290
Carcinoma, Hepatocellular 11 | 228
Cognitive delay 11 | 608
Cryptorchidism 11 | 296
Depressive disorder 11 | 409
Feeding difficulties in infancy 11 | 175
Global developmental delay 11 | 608
Hypoplastic mandible condyle 11 | 275
Liver carcinoma 11 | 240
Lung Neoplasms 11 | 232
Mandibular hypoplasia 11 | 275
Mental and motor retardation 11 | 608
Micrognathism 11 | 275
Noonan syndrome 11 | 34
colon cancer 11 | 1,478
Alzheimer's disease 10 | 658
Heart disease 10 | 306
Low-set, posteriorly rotated ears 10 | 110
Pectus excavatum 10 | 100
Stomach Neoplasms 10 | 300
Waldenstrons macroglobulinemia 10 | 765
cutaneous lupus erythematosus 10 | 1,057
dermatomyositis 10 | 966
medulloblastoma 10 | 720

Tissue

Digestive Tract 124 | 17,369
Endocrine System 124 | 18,159
Liver and Pancreas 124 | 16,750
Male tissues 124 | 17,142
Blood and immune system 123 | 16,909
Female tissues 123 | 17,400
Nervous System 123 | 16,725
Respiratory system 123 | 16,393
Skin and soft tissues 123 | 17,230
Urinary Tract 123 | 16,678
Cardiovascular System 121 | 15,192

Target Family

Kinase 45 | 634
Transcription Factor 28 | 1,400
Enzyme 26 | 4,145
Non-IDG 22 | 12,091
Ion Channel 3 | 344

PathwayCommons: panther Pathway

http://identifiers.org/panther... 124 | 124
http://identifiers.org/panther... 264 | 264
http://identifiers.org/panther... 197 | 197
http://identifiers.org/panther... 164 | 164
http://identifiers.org/panther... 151 | 151
http://identifiers.org/panther... 150 | 150
http://identifiers.org/panther... 149 | 149
http://identifiers.org/panther... 146 | 146
http://identifiers.org/panther... 118 | 118
http://identifiers.org/panther... 116 | 116
http://identifiers.org/panther... 115 | 115
http://identifiers.org/panther... 110 | 110
http://identifiers.org/panther... 107 | 107
http://identifiers.org/panther... 104 | 104
http://identifiers.org/panther... 91 | 91
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 86 | 86
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 67 | 67
http://identifiers.org/panther... 65 | 65
http://identifiers.org/panther... 63 | 63
http://identifiers.org/panther... 61 | 61
http://identifiers.org/panther... 60 | 60
http://identifiers.org/panther... 56 | 56
http://identifiers.org/panther... 54 | 54
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 51 | 51
http://identifiers.org/panther... 47 | 47
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 44 | 44
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 41 | 41
http://identifiers.org/panther... 38 | 38
http://identifiers.org/panther... 37 | 37
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 33 | 33
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 31 | 31
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 27 | 27
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 17 | 17
http://identifiers.org/panther... 16 | 16
http://identifiers.org/panther... 15 | 15
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 13 | 13
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 8 | 8
http://identifiers.org/panther... 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Mitogen-activated protein kinase kinase kinase 4 MAP3K4 Tbio Kinase -1.49704 31.8 244
ETS-related transcription factor Elf-5 ELF5 Tbio Transcription Factor -1.72839 58.0 200
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.26563 21.6 158
Rho GTPase-activating protein 6 ARHGAP6 Tbio Enzyme -0.85601 8.06 45
Friend leukemia integration 1 transcription factor FLI1 Tbio Transcription Factor -1.82504 66.8 454
Rho GTPase-activating protein 9 ARHGAP9 Tbio Enzyme -1.74771 54.3 35
ETS-related transcription factor Elf-3 ELF3 Tbio Transcription Factor -2.42034 268.3 328
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448