Development Level

Tbio 39 | 11,445
Tchem 32 | 1,598
Tclin 17 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal bone structure 3 | 187
decreased total body fat amoun... 3 | 207
enlarged heart 3 | 210
improved glucose tolerance 3 | 79
increased mean corpuscular hem... 3 | 96
preweaning lethality, incomple... 3 | 499
abnormal bone mineralization 2 | 38
abnormal heart morphology 2 | 162
abnormal spleen morphology 2 | 55
decreased blood urea nitrogen ... 2 | 51
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased startle reflex 2 | 75
enlarged lymph nodes 2 | 37
hypoactivity 2 | 132
increased bone mineral density 2 | 72
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased circulating glucose ... 2 | 24
increased lean body mass 2 | 172
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal coat appearance 1 | 31
abnormal colon morphology 1 | 3
abnormal cornea morphology 1 | 31
abnormal duodenum morphology 1 | 4
abnormal epididymis morphology 1 | 42
abnormal eye anterior chamber ... 1 | 9
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
cataract 1 | 92
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased circulating HDL chol... 1 | 68
decreased circulating chloride... 1 | 30
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
enlarged testis 1 | 6
female infertility 1 | 60
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased B cell number 1 | 9
increased T cell number 1 | 6
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating total pr... 1 | 28
increased heart rate 1 | 23
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
male infertility 1 | 123
prenatal lethality 1 | 28
short tibia 1 | 97
small seminal vesicle 1 | 10
small testis 1 | 58
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Cancer 65 | 2,499
Carcinoma 63 | 11,493
psoriasis 52 | 6,694
osteosarcoma 50 | 7,950
ovarian cancer 50 | 8,520
lung cancer 40 | 4,740
glioblastoma 37 | 5,792
medulloblastoma, large-cell 31 | 6,241
Breast cancer 28 | 3,578
atypical teratoid / rhabdoid tumor 28 | 5,112
tuberculosis 27 | 2,010
malignant mesothelioma 25 | 3,232
Rheumatoid arthritis 24 | 1,191
lung carcinoma 24 | 2,843
Asthma 23 | 385
Inflammatory bowel disease 23 | 151
ependymoma 23 | 4,679
diabetes mellitus 22 | 1,728
ulcerative colitis 22 | 1,819
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
Arthritis 20 | 290
interstitial cystitis 20 | 2,312
Astrocytoma, Pilocytic 19 | 3,081
Hypersensitivity reaction type II disease 19 | 253
Kidney cancer 19 | 2,613
adult high grade glioma 19 | 3,801
group 4 medulloblastoma 19 | 1,855
subependymal giant cell astrocytoma 19 | 2,287
Schizophrenia 18 | 1,160
Multiple Sclerosis 17 | 540
group 3 medulloblastoma 17 | 4,104
invasive ductal carcinoma 17 | 2,951
Obesity 16 | 678
Prostatic Neoplasms 16 | 495
Vascular disease 16 | 319
pancreatic cancer 16 | 2,398
astrocytoma 15 | 1,146
lung adenocarcinoma 15 | 2,716
non-small cell lung cancer 15 | 2,890
Breast Neoplasms 14 | 445
Dermatitis 14 | 157
Kidney disease 14 | 430
Liver carcinoma 14 | 240
Lung Neoplasms 14 | 232
Mammary Neoplasms 14 | 425
Multiple myeloma 14 | 1,332
Stomach Neoplasms 14 | 300
Carcinoma, Hepatocellular 13 | 228
Lung disease 13 | 142
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
Alzheimer's disease 12 | 658
Autosomal recessive predisposition 12 | 1,442
Depressive disorder 12 | 409
Ovarian Neoplasms 12 | 102
Pneumonia 12 | 174
Renal Cell Carcinoma 12 | 214
cutaneous lupus erythematosus 12 | 1,057
ductal carcinoma in situ 12 | 1,745
oligodendroglioma 12 | 2,850
pituitary cancer 12 | 1,972
Allergic hypersensitivity disease 11 | 126
Allergic rhinitis 11 | 94
Arthritis, Rheumatoid 11 | 174
Heart disease 11 | 306
Hypereosinophilic syndrome 11 | 71
Mental Depression 11 | 333
juvenile dermatomyositis 11 | 1,187
non-small cell lung carcinoma 11 | 317
ovarian neoplasm 11 | 99
Anemia 10 | 365
Atopic dermatitis 10 | 952
Brain Ischemia 10 | 110
Diarrhea 10 | 253
Hypertension 10 | 396
Neoplasm Metastasis 10 | 168
Orbital separation excessive 10 | 244
astrocytic glioma 10 | 2,597
periodontitis 10 | 293
primary pancreatic ductal adenocarcinoma 10 | 1,109
primitive neuroectodermal tumor 10 | 3,035
Acquired scoliosis 9 | 281
Atherosclerosis 9 | 291
Bipolar Disorder 9 | 666
Byzanthine arch palate 9 | 194
Curvature of spine 9 | 282
Epilepsy 9 | 792
Hyperalgesia 9 | 83
Hypersensitivity 9 | 63
Intellectual disability 9 | 1,016
Pick disease 9 | 1,894
Reperfusion Injury 9 | 86
Seizures 9 | 596
Short stature 9 | 531
active Crohn's disease 9 | 922
breast carcinoma 9 | 1,638
colon cancer 9 | 1,478
cystic fibrosis 9 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
spina bifida 9 | 1,074

Tissue

Blood and immune system 87 | 16,909
Digestive Tract 87 | 17,369
Skin and soft tissues 86 | 17,230
Endocrine System 85 | 18,159
Liver and Pancreas 85 | 16,750
Male tissues 85 | 17,142
Urinary Tract 85 | 16,678
Respiratory system 83 | 16,393
Female tissues 82 | 17,400
Nervous System 82 | 16,725
Cardiovascular System 80 | 15,192

Target Family

Non-IDG 39 | 12,091
Kinase 26 | 634
Transcription Factor 16 | 1,400
Enzyme 5 | 4,145
GPCR 2 | 408

PathwayCommons: panther Pathway

http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 264 | 264
http://identifiers.org/panther... 197 | 197
http://identifiers.org/panther... 164 | 164
http://identifiers.org/panther... 151 | 151
http://identifiers.org/panther... 150 | 150
http://identifiers.org/panther... 149 | 149
http://identifiers.org/panther... 146 | 146
http://identifiers.org/panther... 124 | 124
http://identifiers.org/panther... 118 | 118
http://identifiers.org/panther... 116 | 116
http://identifiers.org/panther... 115 | 115
http://identifiers.org/panther... 110 | 110
http://identifiers.org/panther... 107 | 107
http://identifiers.org/panther... 104 | 104
http://identifiers.org/panther... 91 | 91
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 86 | 86
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 67 | 67
http://identifiers.org/panther... 65 | 65
http://identifiers.org/panther... 63 | 63
http://identifiers.org/panther... 61 | 61
http://identifiers.org/panther... 60 | 60
http://identifiers.org/panther... 56 | 56
http://identifiers.org/panther... 54 | 54
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 51 | 51
http://identifiers.org/panther... 47 | 47
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 44 | 44
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 41 | 41
http://identifiers.org/panther... 38 | 38
http://identifiers.org/panther... 37 | 37
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 33 | 33
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 31 | 31
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 27 | 27
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 17 | 17
http://identifiers.org/panther... 16 | 16
http://identifiers.org/panther... 15 | 15
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 13 | 13
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 8 | 8
http://identifiers.org/panther... 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.26563 21.6 158
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.05079 1139.0 397
MAP kinase-interacting serine/threonine-protein kinase 2 MKNK2 Tchem Kinase -1.32729 19.5 234
C-X-C chemokine receptor type 2 CXCR2 Tchem GPCR -2.87313 723.9 643
C-X-C chemokine receptor type 1 CXCR1 Tchem GPCR -2.48051 278.1 378
ETS domain-containing protein Elk-3 ELK3 Tbio Transcription Factor -0.17124 0.86 225
Ribosomal protein S6 kinase alpha-3 RPS6KA3 Tchem Kinase -2.50143 325.4 425
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864