Development Level

Tbio 117 | 11,445
Tchem 31 | 1,598
Tclin 14 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 14 | 979
decreased body weight 5 | 161
preweaning lethality, incomple... 5 | 499
abnormal embryo size 4 | 220
decreased total body fat amoun... 4 | 207
embryonic lethality prior to t... 4 | 278
abnormal behavior 3 | 298
abnormal femur morphology 3 | 14
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
embryonic growth retardation 3 | 106
embryonic lethality prior to o... 3 | 239
impaired glucose tolerance 3 | 75
increased circulating triglyce... 3 | 42
short tibia 3 | 97
abnormal behavioral response t... 2 | 66
abnormal lens morphology 2 | 81
abnormal retina morphology 2 | 71
decreased circulating creatini... 2 | 39
decreased circulating fructosa... 2 | 30
decreased circulating total pr... 2 | 49
decreased grip strength 2 | 116
decreased neutrophil cell numb... 2 | 42
enlarged heart 2 | 210
hyperactivity 2 | 148
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
increased hematocrit 2 | 46
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 96
increased neutrophil cell numb... 2 | 46
increased red blood cell distr... 2 | 34
persistence of hyaloid vascula... 2 | 33
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal pelvic girdle bone mo... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal radius morphology 1 | 8
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
cataract 1 | 92
decreased NK cell number 1 | 2
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
dilated heart left ventricle 1 | 11
edema 1 | 59
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
increased startle reflex 1 | 112
pallor 1 | 34
polycystic kidney 1 | 15
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8
vertebral fusion 1 | 23

Disease

Carcinoma 134 | 11,493
ovarian cancer 115 | 8,520
glioblastoma 95 | 5,792
osteosarcoma 87 | 7,950
lung cancer 77 | 4,740
psoriasis 71 | 6,694
Kidney cancer 69 | 2,613
Breast cancer 68 | 3,578
Cancer 68 | 2,499
atypical teratoid / rhabdoid tumor 68 | 5,112
medulloblastoma, large-cell 68 | 6,241
pancreatic cancer 67 | 2,398
ependymoma 63 | 4,679
Astrocytoma, Pilocytic 61 | 3,081
invasive ductal carcinoma 51 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 49 | 3,291
malignant mesothelioma 47 | 3,232
non-small cell lung cancer 47 | 2,890
adult high grade glioma 46 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 45 | 2,955
lung carcinoma 44 | 2,843
lung adenocarcinoma 42 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,989
primary pancreatic ductal adenocarcinoma 38 | 1,109
interstitial cystitis 37 | 2,312
primitive neuroectodermal tumor 37 | 3,035
subependymal giant cell astrocytoma 37 | 2,287
ulcerative colitis 37 | 1,819
group 3 medulloblastoma 36 | 4,104
oligodendroglioma 36 | 2,850
Autosomal recessive predisposition 34 | 1,442
cystic fibrosis 33 | 1,696
juvenile dermatomyositis 33 | 1,187
astrocytic glioma 31 | 2,597
breast carcinoma 31 | 1,638
group 4 medulloblastoma 31 | 1,855
tuberculosis 31 | 2,010
diabetes mellitus 29 | 1,728
Duchenne muscular dystrophy 28 | 601
Short stature 28 | 531
gastric carcinoma 28 | 807
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,962
pituitary cancer 28 | 1,972
Melanoma 26 | 711
Pick disease 26 | 1,894
ductal carcinoma in situ 26 | 1,745
astrocytoma 24 | 1,146
pediatric high grade glioma 24 | 1,064
Acquired scoliosis 23 | 281
Curvature of spine 23 | 282
Liver Cirrhosis, Experimental 23 | 769
Hypoplastic mandible condyle 22 | 275
Mandibular hypoplasia 22 | 275
Micrognathism 22 | 275
Muscle hypotonia 22 | 571
Myopia 22 | 176
Skin cancer 22 | 469
autosomal dominant Emery-Dreifuss muscular dystrophy 22 | 510
dermatomyositis 22 | 966
nasopharyngeal carcinoma 21 | 1,058
Intellectual disability 20 | 1,016
Joint hyperflexibility 20 | 78
Orbital separation excessive 20 | 244
Schizophrenia 20 | 1,160
colon cancer 20 | 1,478
Multiple myeloma 19 | 1,332
acute quadriplegic myopathy 19 | 1,158
cutaneous lupus erythematosus 18 | 1,057
Byzanthine arch palate 17 | 194
Dull intelligence 17 | 645
Kidney disease 17 | 430
Low intelligence 17 | 645
Mental Retardation 17 | 645
Mental deficiency 17 | 645
Pectus excavatum 17 | 100
Poor school performance 17 | 645
Rheumatoid arthritis 17 | 1,191
adrenocortical carcinoma 17 | 1,428
primary Sjogren syndrome 17 | 735
Liver cancer 16 | 604
active ulcerative colitis 16 | 764
esophageal adenocarcinoma 16 | 737
urothelial carcinoma 16 | 318
Becker muscular dystrophy 15 | 191
Cognitive delay 15 | 608
Epilepsy 15 | 792
Failure to gain weight 15 | 365
Frontal bossing 15 | 157
Global developmental delay 15 | 608
Mental and motor retardation 15 | 608
Pediatric failure to thrive 15 | 365
Sensorineural Hearing Loss (disorder) 15 | 284
Blepharoptosis 14 | 231
Vascular disease 14 | 319
acute myeloid leukemia 14 | 783
medulloblastoma 14 | 720
Cataract 13 | 297
Feeding difficulties in infancy 13 | 175
Seizures 13 | 596
limb girdle muscular dystrophy 2A 13 | 213

Tissue

Endocrine System 164 | 18,159
Female tissues 164 | 17,400
Male tissues 163 | 17,142
Skin and soft tissues 163 | 17,230
Blood and immune system 162 | 16,909
Digestive Tract 162 | 17,369
Liver and Pancreas 162 | 16,750
Nervous System 162 | 16,725
Urinary Tract 161 | 16,678
Respiratory system 160 | 16,393
Cardiovascular System 157 | 15,192

Target Family

Non-IDG 107 | 12,091
Kinase 31 | 634
Enzyme 26 | 4,145

PathwayCommons: panther Pathway

http://identifiers.org/panther... 164 | 164
http://identifiers.org/panther... 264 | 264
http://identifiers.org/panther... 197 | 197
http://identifiers.org/panther... 151 | 151
http://identifiers.org/panther... 150 | 150
http://identifiers.org/panther... 149 | 149
http://identifiers.org/panther... 146 | 146
http://identifiers.org/panther... 124 | 124
http://identifiers.org/panther... 118 | 118
http://identifiers.org/panther... 116 | 116
http://identifiers.org/panther... 115 | 115
http://identifiers.org/panther... 110 | 110
http://identifiers.org/panther... 107 | 107
http://identifiers.org/panther... 104 | 104
http://identifiers.org/panther... 91 | 91
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 86 | 86
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 67 | 67
http://identifiers.org/panther... 65 | 65
http://identifiers.org/panther... 63 | 63
http://identifiers.org/panther... 61 | 61
http://identifiers.org/panther... 60 | 60
http://identifiers.org/panther... 56 | 56
http://identifiers.org/panther... 54 | 54
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 51 | 51
http://identifiers.org/panther... 47 | 47
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 44 | 44
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 41 | 41
http://identifiers.org/panther... 38 | 38
http://identifiers.org/panther... 37 | 37
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 33 | 33
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 31 | 31
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 27 | 27
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 17 | 17
http://identifiers.org/panther... 16 | 16
http://identifiers.org/panther... 15 | 15
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 13 | 13
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 8 | 8
http://identifiers.org/panther... 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase kinase kinase 4 MAP3K4 Tbio Kinase -1.49704 31.8 244
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Integrin beta-like protein 1 ITGBL1 Tbio Non-IDG -0.73415 6.42 83
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 ASAP1 Tbio Non-IDG -1.76454 62.6 183
Collagen alpha-1(XII) chain COL12A1 Tbio Non-IDG -1.36571 21.4 38
Collagen alpha-1(XV) chain COL15A1 Tbio Non-IDG -1.18716 15.5 74
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Mitogen-activated protein kinase kinase kinase 2 MAP3K2 Tchem Kinase -1.47034 26.6 199
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583
Collagen alpha-1(VI) chain COL6A1 Tbio Non-IDG -2.03348 104.7 204