Development Level

Tbio 46 | 11,445
Tchem 46 | 1,598
Tclin 10 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 12 | 979
abnormal bone structure 5 | 187
embryonic lethality prior to t... 5 | 278
abnormal embryo size 4 | 220
decreased body weight 4 | 161
cataract 3 | 92
embryonic lethality prior to o... 3 | 239
enlarged lymph nodes 3 | 37
increased circulating choleste... 3 | 66
increased total body fat amoun... 3 | 134
preweaning lethality, incomple... 3 | 499
short tibia 3 | 97
abnormal behavior 2 | 298
abnormal bone mineralization 2 | 38
abnormal lens morphology 2 | 81
abnormal retinal vasculature m... 2 | 27
abnormal skin morphology 2 | 50
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased hematocrit 2 | 46
decreased lean body mass 2 | 135
embryonic growth retardation 2 | 106
hypoactivity 2 | 132
impaired pupillary reflex 2 | 26
increased circulating alkaline... 2 | 122
increased erythrocyte cell num... 2 | 39
increased hematocrit 2 | 46
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
male infertility 2 | 123
abnormal body wall morphology 1 | 9
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal locomotor behavior 1 | 24
abnormal optic disc morphology 1 | 10
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal startle reflex 1 | 15
abnormal tail morphology 1 | 25
abnormal testis morphology 1 | 43
absent startle reflex 1 | 24
cleft palate 1 | 8
corneal opacity 1 | 32
decreased IgG3 level 1 | 1
decreased body length 1 | 101
decreased cardiac muscle contr... 1 | 11
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating free fat... 1 | 31
decreased circulating potassiu... 1 | 20
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
fused cornea and lens 1 | 5
hemorrhage 1 | 23
impaired righting response 1 | 26
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased body length 1 | 32
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
iris synechia 1 | 3
narrow eye opening 1 | 12
no spontaneous movement 1 | 1
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Carcinoma 78 | 11,493
ovarian cancer 62 | 8,520
Cancer 58 | 2,499
glioblastoma 55 | 5,792
osteosarcoma 55 | 7,950
atypical teratoid / rhabdoid tumor 49 | 5,112
medulloblastoma, large-cell 49 | 6,241
lung cancer 47 | 4,740
psoriasis 41 | 6,694
ependymoma 39 | 4,679
adult high grade glioma 37 | 3,801
Breast cancer 30 | 3,578
astrocytic glioma 30 | 2,597
group 3 medulloblastoma 29 | 4,104
Astrocytoma, Pilocytic 26 | 3,081
malignant mesothelioma 26 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
primitive neuroectodermal tumor 25 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
oligodendroglioma 24 | 2,850
subependymal giant cell astrocytoma 24 | 2,287
Kidney cancer 23 | 2,613
lung adenocarcinoma 23 | 2,716
lung carcinoma 23 | 2,843
invasive ductal carcinoma 22 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
Orbital separation excessive 19 | 244
Schizophrenia 19 | 1,160
Downward slant of palpebral fissure 18 | 158
non-small cell lung cancer 18 | 2,890
Pick disease 17 | 1,894
group 4 medulloblastoma 17 | 1,855
interstitial cystitis 17 | 2,312
pituitary cancer 17 | 1,972
Epilepsy 15 | 792
Intellectual disability 15 | 1,016
pancreatic cancer 15 | 2,398
tuberculosis 15 | 2,010
Bipolar Disorder 14 | 666
Cryptorchidism 14 | 296
Dull intelligence 14 | 645
Low intelligence 14 | 645
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Poor school performance 14 | 645
Seizures 14 | 596
Byzanthine arch palate 13 | 194
Cognitive delay 13 | 608
Depressive disorder 13 | 409
Global developmental delay 13 | 608
High forehead 13 | 102
Lung Neoplasms 13 | 232
Mental and motor retardation 13 | 608
Multiple myeloma 13 | 1,332
Strabismus 13 | 270
Tall forehead 13 | 102
breast carcinoma 13 | 1,638
Blepharoptosis 12 | 231
Breast Neoplasms 12 | 445
Hypoplastic mandible condyle 12 | 275
Mammary Neoplasms 12 | 425
Mandibular hypoplasia 12 | 275
Micrognathism 12 | 275
Muscle hypotonia 12 | 571
Rheumatoid arthritis 12 | 1,191
Short stature 12 | 531
Vascular disease 12 | 319
colon cancer 12 | 1,478
diabetes mellitus 12 | 1,728
juvenile dermatomyositis 12 | 1,187
Concave bridge of nose 11 | 195
Depressed nasal bridge 11 | 195
Depressed nasal root/bridge 11 | 195
Mental Depression 11 | 333
Pectus excavatum 11 | 100
Stomach Neoplasms 11 | 300
Waldenstrons macroglobulinemia 11 | 765
adrenocortical carcinoma 11 | 1,428
ductal carcinoma in situ 11 | 1,745
primary pancreatic ductal adenocarcinoma 11 | 1,109
ulcerative colitis 11 | 1,819
Acquired scoliosis 10 | 281
Autosomal recessive predisposition 10 | 1,442
Big calvaria 10 | 147
Curvature of spine 10 | 282
Increased head circumference 10 | 147
Increased size of cranium 10 | 147
Increased size of skull 10 | 147
Noonan syndrome 10 | 34
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
spina bifida 10 | 1,074
Cleft Lip 9 | 141
Cleft Palate 9 | 271
Delayed bone age 9 | 136
Frontal bossing 9 | 157
Hypogonadotropic hypogonadism 9 | 89
Low-set, posteriorly rotated ears 9 | 110
Feeding difficulties in infancy 8 | 175
cystic fibrosis 8 | 1,696
dermatomyositis 8 | 966

Tissue

Endocrine System 103 | 18,159
Digestive Tract 102 | 17,369
Nervous System 102 | 16,725
Blood and immune system 101 | 16,909
Female tissues 101 | 17,400
Male tissues 101 | 17,142
Skin and soft tissues 101 | 17,230
Liver and Pancreas 100 | 16,750
Urinary Tract 100 | 16,678
Respiratory system 99 | 16,393
Cardiovascular System 96 | 15,192

Target Family

Kinase 45 | 634
Non-IDG 35 | 12,091
Enzyme 24 | 4,145

PathwayCommons: panther Pathway

http://identifiers.org/panther... 104 | 104
http://identifiers.org/panther... 264 | 264
http://identifiers.org/panther... 197 | 197
http://identifiers.org/panther... 164 | 164
http://identifiers.org/panther... 151 | 151
http://identifiers.org/panther... 150 | 150
http://identifiers.org/panther... 149 | 149
http://identifiers.org/panther... 146 | 146
http://identifiers.org/panther... 124 | 124
http://identifiers.org/panther... 118 | 118
http://identifiers.org/panther... 116 | 116
http://identifiers.org/panther... 115 | 115
http://identifiers.org/panther... 110 | 110
http://identifiers.org/panther... 107 | 107
http://identifiers.org/panther... 91 | 91
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 86 | 86
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 67 | 67
http://identifiers.org/panther... 65 | 65
http://identifiers.org/panther... 63 | 63
http://identifiers.org/panther... 61 | 61
http://identifiers.org/panther... 60 | 60
http://identifiers.org/panther... 56 | 56
http://identifiers.org/panther... 54 | 54
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 51 | 51
http://identifiers.org/panther... 47 | 47
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 44 | 44
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 41 | 41
http://identifiers.org/panther... 38 | 38
http://identifiers.org/panther... 37 | 37
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 33 | 33
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 31 | 31
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 27 | 27
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 17 | 17
http://identifiers.org/panther... 16 | 16
http://identifiers.org/panther... 15 | 15
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 13 | 13
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 8 | 8
http://identifiers.org/panther... 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase kinase kinase 4 MAP3K4 Tbio Kinase -1.49704 31.8 244
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.70843 3.59 261
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GRB2-related adapter protein GRAP Tbio Non-IDG -1.51362 31.8 124
Mitogen-activated protein kinase kinase kinase 2 MAP3K2 Tchem Kinase -1.47034 26.6 199
Fibroblast growth factor 18 FGF18 Tbio Non-IDG -1.89822 84.6 146
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328