Development Level

Tchem 52 | 1,598
Tbio 51 | 11,445
Tclin 10 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 7 | 979
decreased body weight 4 | 161
preweaning lethality, incomple... 4 | 499
enlarged lymph nodes 3 | 37
short tibia 3 | 97
abnormal bone mineralization 2 | 38
abnormal bone structure 2 | 187
abnormal gait 2 | 69
abnormal skin morphology 2 | 50
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
embryonic lethality prior to o... 2 | 239
increased circulating alkaline... 2 | 122
increased erythrocyte cell num... 2 | 39
increased hematocrit 2 | 46
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
abnormal behavior 1 | 298
abnormal coat appearance 1 | 31
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal glucose homeostasis 1 | 4
abnormal hair growth 1 | 10
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal retina morphology 1 | 71
abnormal testis morphology 1 | 43
absent pinna reflex 1 | 23
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating free fat... 1 | 31
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
impaired righting response 1 | 26
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased heart left ventricle... 1 | 4
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
male infertility 1 | 123
prenatal lethality 1 | 28
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Carcinoma 89 | 11,493
ovarian cancer 72 | 8,520
Cancer 67 | 2,499
osteosarcoma 66 | 7,950
glioblastoma 63 | 5,792
medulloblastoma, large-cell 58 | 6,241
atypical teratoid / rhabdoid tumor 55 | 5,112
lung cancer 55 | 4,740
psoriasis 49 | 6,694
ependymoma 48 | 4,679
Breast cancer 43 | 3,578
adult high grade glioma 40 | 3,801
Kidney cancer 38 | 2,613
lung adenocarcinoma 37 | 2,716
Astrocytoma, Pilocytic 32 | 3,081
astrocytic glioma 32 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 32 | 3,291
group 3 medulloblastoma 31 | 4,104
malignant mesothelioma 30 | 3,232
subependymal giant cell astrocytoma 30 | 2,287
interstitial cystitis 29 | 2,312
pancreatic cancer 29 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 28 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,955
invasive ductal carcinoma 27 | 2,951
lung carcinoma 27 | 2,843
primitive neuroectodermal tumor 27 | 3,035
oligodendroglioma 26 | 2,850
ulcerative colitis 26 | 1,819
non-small cell lung cancer 24 | 2,890
Schizophrenia 22 | 1,160
group 4 medulloblastoma 22 | 1,855
Rheumatoid arthritis 21 | 1,191
juvenile dermatomyositis 20 | 1,187
spina bifida 20 | 1,074
tuberculosis 20 | 2,010
Pick disease 19 | 1,894
pituitary cancer 19 | 1,972
Multiple myeloma 17 | 1,332
Orbital separation excessive 17 | 244
primary pancreatic ductal adenocarcinoma 17 | 1,109
Lung Neoplasms 16 | 232
Melanoma 16 | 711
ductal carcinoma in situ 16 | 1,745
Breast Neoplasms 15 | 445
Downward slant of palpebral fissure 15 | 158
Mammary Neoplasms 15 | 425
diabetes mellitus 15 | 1,728
Bipolar Disorder 14 | 666
Neoplasm Metastasis 14 | 168
Noonan syndrome 14 | 34
Prostatic Neoplasms 14 | 495
Stomach Neoplasms 14 | 300
Vascular disease 14 | 319
breast carcinoma 14 | 1,638
pediatric high grade glioma 14 | 1,064
Intellectual disability 13 | 1,016
Short stature 13 | 531
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Acquired scoliosis 12 | 281
Asthma 12 | 385
Blepharoptosis 12 | 231
Byzanthine arch palate 12 | 194
Cognitive delay 12 | 608
Cryptorchidism 12 | 296
Curvature of spine 12 | 282
Dull intelligence 12 | 645
Global developmental delay 12 | 608
Hypoplastic mandible condyle 12 | 275
Low intelligence 12 | 645
Mandibular hypoplasia 12 | 275
Mental Retardation 12 | 645
Mental and motor retardation 12 | 608
Mental deficiency 12 | 645
Micrognathism 12 | 275
Muscle hypotonia 12 | 571
Poor school performance 12 | 645
adrenocortical carcinoma 12 | 1,428
cutaneous lupus erythematosus 12 | 1,057
cystic fibrosis 12 | 1,696
Concave bridge of nose 11 | 195
Depressed nasal bridge 11 | 195
Depressed nasal root/bridge 11 | 195
Epilepsy 11 | 792
Heart disease 11 | 306
High forehead 11 | 102
Neck webbing 11 | 35
Pectus excavatum 11 | 100
Seizures 11 | 596
Tall forehead 11 | 102
Waldenstrons macroglobulinemia 11 | 765
acute quadriplegic myopathy 11 | 1,158
astrocytoma 11 | 1,146
primary Sjogren syndrome 11 | 735
Autosomal recessive predisposition 10 | 1,442
Depressive disorder 10 | 409
Short neck 10 | 140
colon cancer 10 | 1,478
dermatomyositis 10 | 966
progressive supranuclear palsy 10 | 676

Tissue

Blood and immune system 115 | 16,909
Digestive Tract 115 | 17,369
Endocrine System 115 | 18,159
Female tissues 115 | 17,400
Liver and Pancreas 115 | 16,750
Male tissues 115 | 17,142
Nervous System 115 | 16,725
Skin and soft tissues 115 | 17,230
Respiratory system 114 | 16,393
Urinary Tract 114 | 16,678
Cardiovascular System 113 | 15,192

Target Family

Kinase 48 | 634
Non-IDG 35 | 12,091
Enzyme 25 | 4,145
Transcription Factor 7 | 1,400

PathwayCommons: panther Pathway

http://identifiers.org/panther... 115 | 115
http://identifiers.org/panther... 264 | 264
http://identifiers.org/panther... 197 | 197
http://identifiers.org/panther... 164 | 164
http://identifiers.org/panther... 151 | 151
http://identifiers.org/panther... 150 | 150
http://identifiers.org/panther... 149 | 149
http://identifiers.org/panther... 146 | 146
http://identifiers.org/panther... 124 | 124
http://identifiers.org/panther... 118 | 118
http://identifiers.org/panther... 116 | 116
http://identifiers.org/panther... 110 | 110
http://identifiers.org/panther... 107 | 107
http://identifiers.org/panther... 104 | 104
http://identifiers.org/panther... 91 | 91
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 86 | 86
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 67 | 67
http://identifiers.org/panther... 65 | 65
http://identifiers.org/panther... 63 | 63
http://identifiers.org/panther... 61 | 61
http://identifiers.org/panther... 60 | 60
http://identifiers.org/panther... 56 | 56
http://identifiers.org/panther... 54 | 54
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 51 | 51
http://identifiers.org/panther... 47 | 47
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 44 | 44
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 41 | 41
http://identifiers.org/panther... 38 | 38
http://identifiers.org/panther... 37 | 37
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 33 | 33
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 31 | 31
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 27 | 27
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 17 | 17
http://identifiers.org/panther... 16 | 16
http://identifiers.org/panther... 15 | 15
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 13 | 13
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 8 | 8
http://identifiers.org/panther... 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
GRB2-associated-binding protein 3 GAB3 Tbio Non-IDG -0.78182 5.77 104
Mitogen-activated protein kinase kinase kinase 4 MAP3K4 Tbio Kinase -1.49704 31.8 244
Ras GTPase-activating protein nGAP RASAL2 Tbio Enzyme -1.51440 33.0 99
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
GRB2-related adapter protein GRAP Tbio Non-IDG -1.51362 31.8 124
Mitogen-activated protein kinase kinase kinase 2 MAP3K2 Tchem Kinase -1.47034 26.6 199
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.70843 3.59 261
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268