Development Level

Tchem 8 | 1,598
Tbio 2 | 11,445
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal embryo size 2 | 220
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal behavior 1 | 298
abnormal coat- hair morphology 1 | 19
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
cataract 1 | 92
embryonic growth retardation 1 | 106
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
small epididymis 1 | 3
small seminal vesicle 1 | 10
small testis 1 | 58

Disease

osteosarcoma 9 | 7,950
Carcinoma 8 | 11,493
ovarian cancer 8 | 8,520
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
malignant mesothelioma 7 | 3,232
psoriasis 7 | 6,694
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
Pick disease 5 | 1,894
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
medulloblastoma, large-cell 5 | 6,241
Porokeratosis of Mibelli 4 | 4
active Crohn's disease 4 | 922
lung cancer 4 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Autosomal recessive predisposition 3 | 1,442
Cancer 3 | 2,499
Carcinoma, Hepatocellular 3 | 228
Disseminated superficial actinic porokeratosis 3 | 4
Liver carcinoma 3 | 240
Porokeratosis, Disseminated Superficial Actinic 3 | 4
invasive ductal carcinoma 3 | 2,951
oligodendroglioma 3 | 2,850
pancreatic cancer 3 | 2,398
posterior fossa group B ependymoma 3 | 416
Aplasia/Hypoplasia of the skin 2 | 16
Breast cancer 2 | 3,578
Cataract 2 | 297
Chagas disease 2 | 39
Hyperkeratosis 2 | 50
Keratosis 2 | 37
Mevalonic aciduria 2 | 16
Mitral valve insufficiency 2 | 49
Multiple myeloma 2 | 1,332
Obesity 2 | 678
Osteoporosis 2 | 363
Photosensitivity of skin 2 | 51
Pruritus 2 | 58
Q fever 2 | 15
Waldenstrons macroglobulinemia 2 | 765
astrocytic glioma 2 | 2,597
atypical teratoid / rhabdoid tumor 2 | 5,112
chronic rhinosinusitis 2 | 512
ependymoma 2 | 4,679
esophageal adenocarcinoma 2 | 737
gastric cancer 2 | 459
group 3 medulloblastoma 2 | 4,104
hepatocellular carcinoma 2 | 547
non-small cell lung cancer 2 | 2,890
Abnormal vision 1 | 52
Aortic Valve Insufficiency 1 | 40
Aphthous stomatitis 1 | 16
Brucellosis 1 | 24
Chromosome Breakage 1 | 36
Coenzyme Q10 deficiency disease 1 | 8
Congenital total cataract 1 | 15
Cutis marmorata 1 | 32
ESR raised 1 | 20
Edema 1 | 81
Elevated serum IgA 1 | 5
Exanthem 1 | 37
Exanthema 1 | 43
Familial Mediterranean fever 1 | 13
Familial cold autoinflammatory syndrome 1 | 10
Gastrointestinal Hemorrhage 1 | 52
Humoral hypercalcemia of malignancy 1 | 6
Hypercalcemia 1 | 59
Hyperlipidemia 1 | 43
Hyperpigmented macules 1 | 42
Hypertriglyceridemia 1 | 17
Idiopathic pulmonary arterial hypertension 1 | 40
Increased chromosomal breakage 1 | 27
Kidney Failure, Chronic 1 | 46
Leukocytosis 1 | 17
Lipidoses 1 | 19
Lipoidosis 1 | 19
Liver Neoplasms, Experimental 1 | 59
Malignant neoplasm of skin 1 | 15
Marijuana Abuse 1 | 31
Mild Mental Retardation 1 | 70
Mitral regurgitation, mild 1 | 32
Muckle-Wells syndrome 1 | 12
Multiple system atrophy 1 | 29
Myalgia 1 | 54
Myocardial Infarction Prevention 1 | 7
Osteitis Deformans 1 | 11
POROKERATOSIS 7, MULTIPLE TYPES 1 | 1
Paget's disease of bone 1 | 36
Papule 1 | 43
Pharyngitis 1 | 17
Phencyclidine abuse 1 | 6
Pityriasis versicolor 1 | 19
Primary Prevention of Coronary Heart Disease 1 | 4
Prinzmetal angina 1 | 6
Progressive cerebellar ataxia 1 | 13
Pyoderma gangrenosum 1 | 9
Recurrent aphthous ulcer 1 | 14
Skin Neoplasms 1 | 69
Tinea cruris 1 | 12
Waterhouse-Friderichsen syndrome 1 | 11

Tissue

Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Skin and soft tissues 12 | 17,230
Blood and immune system 11 | 16,909
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Respiratory system 11 | 16,393
Urinary Tract 11 | 16,678

Target Family

Enzyme 11 | 4,145
Kinase 1 | 634

PathwayCommons: panther Pathway

http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 264 | 264
http://identifiers.org/panther... 197 | 197
http://identifiers.org/panther... 164 | 164
http://identifiers.org/panther... 151 | 151
http://identifiers.org/panther... 150 | 150
http://identifiers.org/panther... 149 | 149
http://identifiers.org/panther... 146 | 146
http://identifiers.org/panther... 124 | 124
http://identifiers.org/panther... 118 | 118
http://identifiers.org/panther... 116 | 116
http://identifiers.org/panther... 115 | 115
http://identifiers.org/panther... 110 | 110
http://identifiers.org/panther... 107 | 107
http://identifiers.org/panther... 104 | 104
http://identifiers.org/panther... 91 | 91
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 86 | 86
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 67 | 67
http://identifiers.org/panther... 65 | 65
http://identifiers.org/panther... 63 | 63
http://identifiers.org/panther... 61 | 61
http://identifiers.org/panther... 60 | 60
http://identifiers.org/panther... 56 | 56
http://identifiers.org/panther... 54 | 54
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 51 | 51
http://identifiers.org/panther... 47 | 47
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 44 | 44
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 41 | 41
http://identifiers.org/panther... 38 | 38
http://identifiers.org/panther... 37 | 37
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 33 | 33
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 31 | 31
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 27 | 27
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 17 | 17
http://identifiers.org/panther... 16 | 16
http://identifiers.org/panther... 15 | 15
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 13 | 13
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 8 | 8
http://identifiers.org/panther... 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR Tclin Enzyme -3.21450 1428.4 229
Farnesyl pyrophosphate synthase FDPS Tclin Enzyme -2.94323 876.8 272
Squalene synthase FDFT1 Tchem Enzyme -2.57966 374.3 291
Geranylgeranyl pyrophosphate synthase GGPS1 Tchem Enzyme -2.30083 190.0 301
Mevalonate kinase MVK Tchem Kinase -2.25702 177.5 271
Lanosterol synthase LSS Tchem Enzyme -2.22381 150.1 87
Diphosphomevalonate decarboxylase MVD Tchem Enzyme -2.09917 118.7 136
Phosphomevalonate kinase PMVK Tchem Enzyme -1.96385 92.3 144
Decaprenyl-diphosphate synthase subunit 1 PDSS1 Tbio Enzyme -1.87900 72.4 49
Squalene monooxygenase SQLE Tchem Enzyme -1.89887 71.9 109