Development Level

Tchem 30 | 1,598
Tbio 13 | 11,445
Tclin 10 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased body weight 3 | 161
preweaning lethality, incomple... 3 | 499
abnormal gait 2 | 69
decreased hemoglobin content 2 | 68
decreased lymphocyte cell numb... 2 | 83
increased erythrocyte cell num... 2 | 39
increased monocyte cell number 2 | 63
increased total body fat amoun... 2 | 134
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
hydrometra 1 | 53
increased CD4-positive, alpha ... 1 | 4
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased circulating glucose ... 1 | 24
increased grip strength 1 | 41
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
prenatal lethality 1 | 28
short tibia 1 | 97
small epididymis 1 | 3
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56

Disease

Carcinoma 43 | 11,493
Cancer 38 | 2,499
ovarian cancer 37 | 8,520
osteosarcoma 34 | 7,950
glioblastoma 28 | 5,792
lung cancer 27 | 4,740
psoriasis 25 | 6,694
medulloblastoma, large-cell 22 | 6,241
subependymal giant cell astrocytoma 21 | 2,287
Astrocytoma, Pilocytic 18 | 3,081
atypical teratoid / rhabdoid tumor 18 | 5,112
Kidney cancer 17 | 2,613
adult high grade glioma 17 | 3,801
ependymoma 16 | 4,679
group 3 medulloblastoma 16 | 4,104
interstitial cystitis 16 | 2,312
Breast cancer 15 | 3,578
Waldenstrons macroglobulinemia 15 | 765
lung carcinoma 15 | 2,843
Arthritis 14 | 290
Rheumatoid arthritis 13 | 1,191
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
Schizophrenia 12 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
invasive ductal carcinoma 12 | 2,951
primary Sjogren syndrome 12 | 735
Autosomal recessive predisposition 11 | 1,442
Pick disease 11 | 1,894
astrocytic glioma 11 | 2,597
colon cancer 11 | 1,478
cutaneous lupus erythematosus 11 | 1,057
diabetes mellitus 11 | 1,728
malignant mesothelioma 11 | 3,232
non-small cell lung cancer 11 | 2,890
oligodendroglioma 11 | 2,850
primitive neuroectodermal tumor 11 | 3,035
tuberculosis 11 | 2,010
group 4 medulloblastoma 10 | 1,855
juvenile dermatomyositis 10 | 1,187
pancreatic cancer 10 | 2,398
ulcerative colitis 10 | 1,819
Dull intelligence 9 | 645
Immunologic Deficiency Syndromes 9 | 113
Intellectual disability 9 | 1,016
Low intelligence 9 | 645
Melanoma 9 | 711
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Muscle hypotonia 9 | 571
Poor school performance 9 | 645
Short stature 9 | 531
Vascular disease 9 | 319
cystic fibrosis 9 | 1,696
Byzanthine arch palate 8 | 194
Downward slant of palpebral fissure 8 | 158
Failure to gain weight 8 | 365
Hepatomegaly 8 | 285
Lung Neoplasms 8 | 232
Multiple myeloma 8 | 1,332
Obesity 8 | 678
Orbital separation excessive 8 | 244
Pediatric failure to thrive 8 | 365
Stomach Neoplasms 8 | 300
acute myeloid leukemia 8 | 783
pituitary cancer 8 | 1,972
Acquired scoliosis 7 | 281
Agammaglobulinemia 7 | 34
Asthma 7 | 385
Blepharoptosis 7 | 231
Breast Neoplasms 7 | 445
Cognitive delay 7 | 608
Cryptorchidism 7 | 296
Curvature of spine 7 | 282
Diarrhea 7 | 253
Global developmental delay 7 | 608
Heart disease 7 | 306
High forehead 7 | 102
Hypoplastic mandible condyle 7 | 275
Kidney disease 7 | 430
Liver Cirrhosis, Experimental 7 | 769
Liver cancer 7 | 604
Lung disease 7 | 142
Mammary Neoplasms 7 | 425
Mandibular hypoplasia 7 | 275
Mental and motor retardation 7 | 608
Micrognathism 7 | 275
Multiple Sclerosis 7 | 540
Neck webbing 7 | 35
Noonan syndrome 7 | 34
Pectus excavatum 7 | 100
Strabismus 7 | 270
Tall forehead 7 | 102
lung adenocarcinoma 7 | 2,716
primary pancreatic ductal adenocarcinoma 7 | 1,109
Prostatic Neoplasms 6 | 495
dermatomyositis 6 | 966
nasopharyngeal carcinoma 6 | 1,058
periodontitis 6 | 293
spina bifida 6 | 1,074

Tissue

Blood and immune system 53 | 16,909
Digestive Tract 53 | 17,369
Endocrine System 53 | 18,159
Female tissues 53 | 17,400
Male tissues 53 | 17,142
Respiratory system 53 | 16,393
Skin and soft tissues 53 | 17,230
Urinary Tract 53 | 16,678
Cardiovascular System 52 | 15,192
Liver and Pancreas 52 | 16,750
Nervous System 52 | 16,725

Target Family

Kinase 26 | 634
Non-IDG 13 | 12,091
Enzyme 9 | 4,145
Ion Channel 3 | 344
Transcription Factor 2 | 1,400

PathwayCommons: panther Pathway

http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 264 | 264
http://identifiers.org/panther... 197 | 197
http://identifiers.org/panther... 164 | 164
http://identifiers.org/panther... 151 | 151
http://identifiers.org/panther... 150 | 150
http://identifiers.org/panther... 149 | 149
http://identifiers.org/panther... 146 | 146
http://identifiers.org/panther... 124 | 124
http://identifiers.org/panther... 118 | 118
http://identifiers.org/panther... 116 | 116
http://identifiers.org/panther... 115 | 115
http://identifiers.org/panther... 110 | 110
http://identifiers.org/panther... 107 | 107
http://identifiers.org/panther... 104 | 104
http://identifiers.org/panther... 91 | 91
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 86 | 86
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 67 | 67
http://identifiers.org/panther... 65 | 65
http://identifiers.org/panther... 63 | 63
http://identifiers.org/panther... 61 | 61
http://identifiers.org/panther... 60 | 60
http://identifiers.org/panther... 56 | 56
http://identifiers.org/panther... 54 | 54
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 51 | 51
http://identifiers.org/panther... 47 | 47
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 44 | 44
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 41 | 41
http://identifiers.org/panther... 38 | 38
http://identifiers.org/panther... 37 | 37
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 33 | 33
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 31 | 31
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 27 | 27
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 17 | 17
http://identifiers.org/panther... 16 | 16
http://identifiers.org/panther... 15 | 15
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 13 | 13
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 8 | 8
http://identifiers.org/panther... 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform PPP3CB Tbio Enzyme -1.53531 28.2 147
Mitogen-activated protein kinase kinase kinase 2 MAP3K2 Tchem Kinase -1.47034 26.6 199
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
Son of sevenless homolog 2 SOS2 Tbio Non-IDG -1.62118 35.9 134
NF-kappa-B inhibitor-like protein 1 NFKBIL1 Tbio Non-IDG -1.41875 29.3 137
Protein kinase C delta type PRKCD Tclin Kinase -2.18452 141.4 804