Development Level

Tchem 54 | 1,388
Tbio 48 | 11,651
Tclin 5 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 4 | 499
decreased circulating creatini... 3 | 39
embryonic lethality prior to t... 3 | 278
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
increased leukocyte cell numbe... 3 | 47
abnormal embryo size 2 | 220
abnormal neural tube closure 2 | 46
abnormal retina morphology 2 | 71
abnormal testis morphology 2 | 43
decreased circulating insulin ... 2 | 76
decreased circulating sodium l... 2 | 22
decreased lean body mass 2 | 135
decreased vertical activity 2 | 208
enlarged heart 2 | 210
increased circulating HDL chol... 2 | 80
increased circulating free fat... 2 | 20
increased lean body mass 2 | 172
increased lymphocyte cell numb... 2 | 32
increased total body fat amoun... 2 | 134
small testis 2 | 58
tremors 2 | 39
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal forebrain development 1 | 20
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
absent testes 1 | 6
absent vibrissae 1 | 12
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased mean corpuscular hem... 1 | 31
decreased monocyte cell number 1 | 8
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
hypoactivity 1 | 132
increased basophil cell number 1 | 7
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased eosinophil cell numb... 1 | 11
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27

Disease

Cancer 76 | 2,499
Carcinoma 65 | 11,493
ovarian cancer 65 | 8,520
osteosarcoma 57 | 7,950
psoriasis 54 | 6,694
lung cancer 53 | 4,740
glioblastoma 49 | 5,792
medulloblastoma, large-cell 42 | 6,241
atypical teratoid / rhabdoid tumor 38 | 5,112
ependymoma 32 | 4,679
tuberculosis 31 | 2,010
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,291
lung carcinoma 28 | 2,843
Schizophrenia 27 | 1,160
Breast cancer 26 | 3,578
group 3 medulloblastoma 26 | 4,104
ulcerative colitis 26 | 1,819
adult high grade glioma 25 | 3,801
Astrocytoma, Pilocytic 24 | 3,081
oligodendroglioma 24 | 2,850
subependymal giant cell astrocytoma 23 | 2,287
Vascular disease 22 | 319
malignant mesothelioma 22 | 3,232
pancreatic cancer 22 | 2,398
Rheumatoid arthritis 21 | 1,191
diabetes mellitus 21 | 1,728
interstitial cystitis 21 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
primitive neuroectodermal tumor 21 | 3,035
non-small cell lung cancer 20 | 2,890
Breast Neoplasms 19 | 445
Mammary Neoplasms 19 | 425
lung adenocarcinoma 19 | 2,716
Kidney cancer 18 | 2,613
cutaneous lupus erythematosus 18 | 1,057
hepatocellular carcinoma 18 | 547
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
invasive ductal carcinoma 18 | 2,951
Multiple myeloma 17 | 1,332
Alzheimer's disease 16 | 658
Brain Ischemia 16 | 110
acute myeloid leukemia 16 | 783
astrocytoma 16 | 1,146
group 4 medulloblastoma 16 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
pituitary cancer 16 | 1,972
Diabetes Mellitus, Experimental 15 | 108
Lung Neoplasms 15 | 232
Splenomegaly 15 | 190
colon cancer 15 | 1,478
Diabetes Mellitus, Type 2 14 | 142
Obesity 14 | 678
Pick disease 14 | 1,894
Prostatic Neoplasms 14 | 495
Stomach Neoplasms 14 | 300
Toxic encephalopathy 14 | 141
adrenocortical carcinoma 14 | 1,428
primary Sjogren syndrome 14 | 735
Arthritis 13 | 290
Diabetes Mellitus, Non-Insulin-Dependent 13 | 145
Liver Cirrhosis, Experimental 13 | 769
Parkinson's disease 13 | 392
astrocytic glioma 13 | 2,597
Autosomal recessive predisposition 12 | 1,442
Bipolar Disorder 12 | 666
Carcinoma, Hepatocellular 12 | 228
Depressive disorder 12 | 409
Hypersensitivity reaction type II disease 12 | 253
Kidney disease 12 | 430
Liver carcinoma 12 | 240
juvenile dermatomyositis 12 | 1,187
Asthma 11 | 385
Colonic Neoplasms 11 | 142
Intellectual disability 11 | 1,016
cystic fibrosis 11 | 1,696
pancreatic carcinoma 11 | 562
Liver disease 10 | 237
Lung disease 10 | 142
Multiple Sclerosis 10 | 540
Myocardial Infarction 10 | 151
Polycystic ovary syndrome 10 | 360
Reperfusion Injury 10 | 86
aldosterone-producing adenoma 10 | 665
breast carcinoma 10 | 1,638
Atopic dermatitis 9 | 952
Cardiomyopathies 9 | 110
Colorectal Neoplasms 9 | 243
Disease Models, Animal 9 | 155
Eye disease 9 | 62
Heart disease 9 | 306
Hypertension 9 | 396
Inflammatory bowel disease 9 | 151
Mental Depression 9 | 333
Neurodegenerative disease 9 | 414
dermatomyositis 9 | 966
nasopharyngeal carcinoma 9 | 1,058
spina bifida 9 | 1,074
esophageal adenocarcinoma 8 | 737
gastric carcinoma 8 | 807
primary pancreatic ductal adenocarcinoma 8 | 1,109

Tissue

Blood and immune system 107 | 16,909
Digestive Tract 107 | 17,369
Endocrine System 107 | 18,159
Female tissues 106 | 17,400
Male tissues 106 | 17,142
Skin and soft tissues 106 | 17,230
Urinary Tract 106 | 16,678
Liver and Pancreas 105 | 16,750
Respiratory system 105 | 16,393
Nervous System 104 | 16,725
Cardiovascular System 102 | 15,192

Target Family

Non-IDG 46 | 12,091
Kinase 33 | 634
Transcription Factor 17 | 1,400
Enzyme 11 | 4,145

PathwayCommons: panther Pathway

http://identifiers.org/panther... 107 | 107
http://identifiers.org/panther... 264 | 264
http://identifiers.org/panther... 197 | 197
http://identifiers.org/panther... 164 | 164
http://identifiers.org/panther... 151 | 151
http://identifiers.org/panther... 150 | 150
http://identifiers.org/panther... 149 | 149
http://identifiers.org/panther... 146 | 146
http://identifiers.org/panther... 124 | 124
http://identifiers.org/panther... 118 | 118
http://identifiers.org/panther... 116 | 116
http://identifiers.org/panther... 115 | 115
http://identifiers.org/panther... 110 | 110
http://identifiers.org/panther... 104 | 104
http://identifiers.org/panther... 91 | 91
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 86 | 86
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 67 | 67
http://identifiers.org/panther... 65 | 65
http://identifiers.org/panther... 63 | 63
http://identifiers.org/panther... 61 | 61
http://identifiers.org/panther... 60 | 60
http://identifiers.org/panther... 56 | 56
http://identifiers.org/panther... 54 | 54
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 51 | 51
http://identifiers.org/panther... 47 | 47
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 44 | 44
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 41 | 41
http://identifiers.org/panther... 38 | 38
http://identifiers.org/panther... 37 | 37
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 33 | 33
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 31 | 31
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 27 | 27
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 17 | 17
http://identifiers.org/panther... 16 | 16
http://identifiers.org/panther... 15 | 15
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 13 | 13
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 8 | 8
http://identifiers.org/panther... 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 Tbio Non-IDG -2.81111 643.5 577
Cyclic AMP-dependent transcription factor ATF-2 ATF2 Tbio Transcription Factor -2.23104 170.7 1819
Cyclic AMP-dependent transcription factor ATF-6 beta ATF6B Tbio Transcription Factor -1.03459 8.22 6
Nuclear factor NF-kappa-B p100 subunit NFKB2 Tchem Transcription Factor -2.29577 191.3 637
Tumor necrosis factor receptor superfamily member 6 FAS Tbio Non-IDG -3.32299 2090.2 2060
Mitogen-activated protein kinase 10 MAPK10 Tchem Kinase -2.29568 193.3 384
Proto-oncogene c-Fos FOS Tbio Transcription Factor -4.14231 13598.8 1058
Tumor necrosis factor ligand superfamily member 10 TNFSF10 Tbio Non-IDG -2.87006 661.9 949
Mitogen-activated protein kinase kinase kinase kinase 3 MAP4K3 Tchem Kinase -1.15845 15.3 254
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440