Development Level

Tchem 69 | 1,598
Tbio 65 | 11,445
Tclin 17 | 613

Collection

Kinase: IDG Consortium (Target... 3 | 125

IMPC Phenotype

preweaning lethality, complete... 15 | 979
decreased body weight 6 | 161
embryonic lethality prior to t... 6 | 278
preweaning lethality, incomple... 6 | 499
embryonic lethality prior to o... 5 | 239
increased total body fat amoun... 4 | 134
abnormal bone mineralization 3 | 38
abnormal bone structure 3 | 187
decreased bone mineral content 3 | 151
decreased bone mineral density 3 | 126
decreased vertical activity 3 | 208
increased circulating choleste... 3 | 66
increased circulating iron lev... 3 | 30
increased lean body mass 3 | 172
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal startle reflex 2 | 15
cataract 2 | 92
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
increased blood urea nitrogen ... 2 | 48
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
increased circulating glucose ... 2 | 24
increased lymphocyte cell numb... 2 | 32
prenatal lethality 2 | 28
short tibia 2 | 97
abnormal brain morphology 1 | 13
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal femur morphology 1 | 14
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 26
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
abnormal whole-body plethysmog... 1 | 4
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased circulating LDL chol... 1 | 38
decreased circulating free fat... 1 | 31
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased neutrophil cell numb... 1 | 42
decreased threshold for audito... 1 | 26
hydroencephaly 1 | 14
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased B cell number 1 | 9
increased T cell number 1 | 6
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased circulating triglyce... 1 | 42
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
mammalian phenotype 1 | 17
prenatal lethality prior to he... 1 | 87
shortened RR interval 1 | 17
small heart 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

Carcinoma 126 | 11,493
Cancer 99 | 2,499
ovarian cancer 92 | 8,520
osteosarcoma 90 | 7,950
glioblastoma 79 | 5,792
psoriasis 73 | 6,694
lung cancer 72 | 4,740
medulloblastoma, large-cell 67 | 6,241
ependymoma 66 | 4,679
Breast cancer 62 | 3,578
atypical teratoid / rhabdoid tumor 60 | 5,112
Kidney cancer 46 | 2,613
oligodendroglioma 43 | 2,850
group 3 medulloblastoma 41 | 4,104
malignant mesothelioma 41 | 3,232
invasive ductal carcinoma 40 | 2,951
Astrocytoma, Pilocytic 39 | 3,081
pancreatic cancer 39 | 2,398
adult high grade glioma 38 | 3,801
non-small cell lung cancer 38 | 2,890
lung adenocarcinoma 36 | 2,716
lung carcinoma 36 | 2,843
Schizophrenia 35 | 1,160
primitive neuroectodermal tumor 35 | 3,035
astrocytic glioma 34 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,989
interstitial cystitis 33 | 2,312
breast carcinoma 32 | 1,638
group 4 medulloblastoma 32 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 32 | 3,291
Breast Neoplasms 31 | 445
Mammary Neoplasms 31 | 425
astrocytoma 30 | 1,146
tuberculosis 30 | 2,010
cystic fibrosis 29 | 1,696
pituitary cancer 29 | 1,972
diabetes mellitus 28 | 1,728
ulcerative colitis 26 | 1,819
ductal carcinoma in situ 24 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 24 | 1,962
subependymal giant cell astrocytoma 24 | 2,287
Lung Neoplasms 23 | 232
colon cancer 23 | 1,478
juvenile dermatomyositis 22 | 1,187
Intellectual disability 21 | 1,016
Orbital separation excessive 21 | 244
Renal Cell Carcinoma 21 | 214
Rheumatoid arthritis 21 | 1,191
Vascular disease 21 | 319
adrenocortical carcinoma 20 | 1,428
Stomach Neoplasms 19 | 300
Dull intelligence 18 | 645
Heart disease 18 | 306
Low intelligence 18 | 645
Mental Retardation 18 | 645
Mental deficiency 18 | 645
Poor school performance 18 | 645
Short stature 18 | 531
dermatomyositis 18 | 966
pediatric high grade glioma 18 | 1,064
Byzanthine arch palate 17 | 194
Cognitive delay 17 | 608
Downward slant of palpebral fissure 17 | 158
Global developmental delay 17 | 608
Hypoplastic mandible condyle 17 | 275
Kidney disease 17 | 430
Mandibular hypoplasia 17 | 275
Mental and motor retardation 17 | 608
Micrognathism 17 | 275
Obesity 17 | 678
Prostatic Neoplasms 17 | 495
primary pancreatic ductal adenocarcinoma 17 | 1,109
spina bifida 17 | 1,074
Carcinoma, Squamous Cell 16 | 110
Cryptorchidism 16 | 296
Pick disease 16 | 1,894
Bipolar Disorder 15 | 666
Epilepsy 15 | 792
Frontal bossing 15 | 157
Seizures 15 | 596
Strabismus 15 | 270
Acquired scoliosis 14 | 281
Alzheimer's disease 14 | 658
Colorectal Neoplasms 14 | 243
Curvature of spine 14 | 282
Depressive disorder 14 | 409
Hypertension 14 | 396
Liver carcinoma 14 | 240
Melanoma 14 | 711
Multiple myeloma 14 | 1,332
Osteoporosis 14 | 363
Skin cancer 14 | 469
Atherosclerosis 13 | 291
Cerebrovascular disease 13 | 238
Concave bridge of nose 13 | 195
Depressed nasal bridge 13 | 195
Depressed nasal root/bridge 13 | 195
pancreatic carcinoma 13 | 562
primary Sjogren syndrome 13 | 735

Tissue

Digestive Tract 150 | 17,369
Endocrine System 149 | 18,159
Liver and Pancreas 148 | 16,750
Blood and immune system 147 | 16,909
Female tissues 147 | 17,400
Skin and soft tissues 147 | 17,230
Urinary Tract 147 | 16,678
Male tissues 146 | 17,142
Nervous System 146 | 16,725
Respiratory system 143 | 16,393
Cardiovascular System 139 | 15,192

Target Family

Non-IDG 60 | 12,091
Kinase 54 | 634
Enzyme 22 | 4,145
Transcription Factor 10 | 1,400
GPCR 5 | 408

PathwayCommons: panther Pathway

http://identifiers.org/panther... 151 | 151
http://identifiers.org/panther... 264 | 264
http://identifiers.org/panther... 197 | 197
http://identifiers.org/panther... 164 | 164
http://identifiers.org/panther... 150 | 150
http://identifiers.org/panther... 149 | 149
http://identifiers.org/panther... 146 | 146
http://identifiers.org/panther... 124 | 124
http://identifiers.org/panther... 118 | 118
http://identifiers.org/panther... 116 | 116
http://identifiers.org/panther... 115 | 115
http://identifiers.org/panther... 110 | 110
http://identifiers.org/panther... 107 | 107
http://identifiers.org/panther... 104 | 104
http://identifiers.org/panther... 91 | 91
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 86 | 86
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 67 | 67
http://identifiers.org/panther... 65 | 65
http://identifiers.org/panther... 63 | 63
http://identifiers.org/panther... 61 | 61
http://identifiers.org/panther... 60 | 60
http://identifiers.org/panther... 56 | 56
http://identifiers.org/panther... 54 | 54
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 51 | 51
http://identifiers.org/panther... 47 | 47
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 44 | 44
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 41 | 41
http://identifiers.org/panther... 38 | 38
http://identifiers.org/panther... 37 | 37
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 33 | 33
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 31 | 31
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 27 | 27
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 17 | 17
http://identifiers.org/panther... 16 | 16
http://identifiers.org/panther... 15 | 15
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 13 | 13
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 8 | 8
http://identifiers.org/panther... 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenomatous polyposis coli protein 2 APC2 Tbio Non-IDG -1.50271 33.3 93
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Ephrin type-B receptor 3 EPHB3 Tchem Kinase -1.68968 47.7 409
GRB2-related adapter protein GRAP Tbio Non-IDG -1.51362 31.8 124
Ephrin type-B receptor 1 EPHB1 Tchem Kinase -1.70013 52.0 389
Cytosolic phospholipase A2 gamma PLA2G4C Tchem Enzyme -1.27690 20.9 63
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Fibroblast growth factor receptor substrate 3 FRS3 Tbio Non-IDG -0.92119 9.61 156