Development Level

Tbio 72 | 11,651
Tchem 35 | 1,388
Tclin 2 | 612
Tdark 1 | 6,593

Collection

GPCR: IDG Consortium (Targets) 1 | 126
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 14 | 979
decreased vertical activity 7 | 208
embryonic lethality prior to t... 7 | 278
preweaning lethality, incomple... 5 | 499
abnormal eye morphology 4 | 68
abnormal heart morphology 4 | 162
enlarged heart 4 | 210
abnormal embryo size 3 | 220
embryonic lethality prior to o... 3 | 239
increased lean body mass 3 | 172
prenatal lethality prior to he... 3 | 87
abnormal behavior 2 | 298
abnormal kidney morphology 2 | 65
abnormal vibrissa morphology 2 | 25
decreased bone mineral density 2 | 126
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
edema 2 | 59
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
pallor 2 | 34
prenatal lethality 2 | 28
short tibia 2 | 97
abnormal bone mineralization 1 | 38
abnormal brain morphology 1 | 13
abnormal esophagus morphology 1 | 5
abnormal eye size 1 | 7
abnormal head morphology 1 | 10
abnormal limb bud morphology 1 | 17
abnormal limb morphology 1 | 13
abnormal pancreas morphology 1 | 13
abnormal pericardium morpholog... 1 | 26
abnormal skin coloration 1 | 25
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
abnormal tail morphology 1 | 25
abnormal thyroid gland morphol... 1 | 3
abnormal trachea morphology 1 | 3
abnormal vertebrae morphology 1 | 18
absent lymph nodes 1 | 3
anophthalmia 1 | 33
athymia 1 | 2
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased bone mineral content 1 | 151
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased coping response 1 | 8
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased respiratory quotient 1 | 16
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
enlarged kidney 1 | 14
enlarged spleen 1 | 41
hemorrhage 1 | 23
hydroencephaly 1 | 14
hydrometra 1 | 53
hydrops fetalis 1 | 1
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating amylase ... 1 | 25
increased circulating insulin ... 1 | 3
increased circulating sodium l... 1 | 71
increased hemoglobin content 1 | 45
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
microphthalmia 1 | 26
premature death 1 | 5
prolonged PR interval 1 | 15
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
respiratory system phenotype 1 | 2
small heart 1 | 10
small superior vagus ganglion 1 | 74

Disease

Carcinoma 97 | 11,493
psoriasis 59 | 6,694
Cancer 50 | 2,499
ovarian cancer 50 | 8,520
osteosarcoma 48 | 7,950
atypical teratoid / rhabdoid tumor 42 | 5,112
ependymoma 39 | 4,679
glioblastoma 38 | 5,792
Breast cancer 36 | 3,578
lung cancer 35 | 4,740
malignant mesothelioma 35 | 3,232
medulloblastoma, large-cell 30 | 6,241
lung carcinoma 27 | 2,843
pancreatic cancer 27 | 2,398
non-small cell lung cancer 26 | 2,890
Astrocytoma, Pilocytic 24 | 3,081
Kidney cancer 24 | 2,613
group 3 medulloblastoma 24 | 4,104
lung adenocarcinoma 24 | 2,716
Alzheimer's disease 23 | 658
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
interstitial cystitis 22 | 2,312
invasive ductal carcinoma 22 | 2,951
oligodendroglioma 22 | 2,850
cystic fibrosis 21 | 1,696
Autosomal recessive predisposition 20 | 1,442
breast carcinoma 20 | 1,638
adult high grade glioma 19 | 3,801
primitive neuroectodermal tumor 19 | 3,035
astrocytic glioma 18 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
Schizophrenia 17 | 1,160
ductal carcinoma in situ 16 | 1,745
group 4 medulloblastoma 16 | 1,855
pituitary cancer 16 | 1,972
primary pancreatic ductal adenocarcinoma 16 | 1,109
subependymal giant cell astrocytoma 16 | 2,287
ulcerative colitis 16 | 1,819
pediatric high grade glioma 15 | 1,064
Osteoporosis 14 | 363
colon cancer 14 | 1,478
diabetes mellitus 14 | 1,728
Breast Neoplasms 13 | 445
Pick disease 13 | 1,894
Rheumatoid arthritis 13 | 1,191
cutaneous lupus erythematosus 13 | 1,057
Bipolar Disorder 12 | 666
Mammary Neoplasms 12 | 425
tuberculosis 12 | 2,010
Down syndrome 11 | 499
Hypertension 11 | 396
Hypoplastic mandible condyle 11 | 275
Kidney disease 11 | 430
Liver Cirrhosis, Experimental 11 | 769
Mandibular hypoplasia 11 | 275
Micrognathism 11 | 275
Short stature 11 | 531
Vascular disease 11 | 319
adrenocortical carcinoma 11 | 1,428
Liver cancer 10 | 604
Orbital separation excessive 10 | 244
gastric carcinoma 10 | 807
non primary Sjogren syndrome sicca 10 | 891
Atopic dermatitis 9 | 952
Colonic Neoplasms 9 | 142
Endometriosis 9 | 540
Intellectual disability 9 | 1,016
Prostatic Neoplasms 9 | 495
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
fibroadenoma 9 | 559
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
posterior fossa group A ependymoma 9 | 468
Cognitive delay 8 | 608
Craniofacial Abnormalities 8 | 151
Cryptorchidism 8 | 296
Dental caries 8 | 164
Dull intelligence 8 | 645
Endometrial cancer 8 | 311
Global developmental delay 8 | 608
Long philtrum 8 | 137
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental and motor retardation 8 | 608
Mental deficiency 8 | 645
Neoplasm Invasiveness 8 | 161
Neoplasm Metastasis 8 | 168
Poor school performance 8 | 645
active Crohn's disease 8 | 922
astrocytoma 8 | 1,146
juvenile dermatomyositis 8 | 1,187
spina bifida 8 | 1,074
Cerebrovascular disease 7 | 238
Chronic obstructive pulmonary disease 7 | 184
Duchenne muscular dystrophy 7 | 601
Gait abnormality 7 | 135
Multiple Sclerosis 7 | 540
Obesity 7 | 678
dermatomyositis 7 | 966
esophageal adenocarcinoma 7 | 737

Tissue

Digestive Tract 106 | 17,369
Female tissues 106 | 17,400
Endocrine System 105 | 18,159
Urinary Tract 104 | 16,678
Skin and soft tissues 103 | 17,230
Blood and immune system 101 | 16,909
Male tissues 101 | 17,142
Liver and Pancreas 100 | 16,750
Nervous System 99 | 16,725
Respiratory system 98 | 16,393
Cardiovascular System 89 | 15,192

Target Family

Non-IDG 55 | 12,091
Enzyme 30 | 4,145
GPCR 10 | 408
Ion Channel 5 | 344
Transcription Factor 5 | 1,400
Kinase 3 | 634
Epigenetic 1 | 242
TF/Epigenetic 1 | 38

PathwayCommons: panther Pathway

http://identifiers.org/panther... 110 | 110
http://identifiers.org/panther... 264 | 264
http://identifiers.org/panther... 197 | 197
http://identifiers.org/panther... 164 | 164
http://identifiers.org/panther... 151 | 151
http://identifiers.org/panther... 150 | 150
http://identifiers.org/panther... 149 | 149
http://identifiers.org/panther... 146 | 146
http://identifiers.org/panther... 124 | 124
http://identifiers.org/panther... 118 | 118
http://identifiers.org/panther... 116 | 116
http://identifiers.org/panther... 115 | 115
http://identifiers.org/panther... 107 | 107
http://identifiers.org/panther... 104 | 104
http://identifiers.org/panther... 91 | 91
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 88 | 88
http://identifiers.org/panther... 86 | 86
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 70 | 70
http://identifiers.org/panther... 67 | 67
http://identifiers.org/panther... 65 | 65
http://identifiers.org/panther... 63 | 63
http://identifiers.org/panther... 61 | 61
http://identifiers.org/panther... 60 | 60
http://identifiers.org/panther... 56 | 56
http://identifiers.org/panther... 54 | 54
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 53 | 53
http://identifiers.org/panther... 51 | 51
http://identifiers.org/panther... 47 | 47
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 46 | 46
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 45 | 45
http://identifiers.org/panther... 44 | 44
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 43 | 43
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 42 | 42
http://identifiers.org/panther... 41 | 41
http://identifiers.org/panther... 38 | 38
http://identifiers.org/panther... 37 | 37
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 35 | 35
http://identifiers.org/panther... 33 | 33
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 32 | 32
http://identifiers.org/panther... 31 | 31
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 30 | 30
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 29 | 29
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 28 | 28
http://identifiers.org/panther... 27 | 27
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 26 | 26
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 24 | 24
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 23 | 23
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 21 | 21
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 19 | 19
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 18 | 18
http://identifiers.org/panther... 17 | 17
http://identifiers.org/panther... 16 | 16
http://identifiers.org/panther... 15 | 15
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 14 | 14
http://identifiers.org/panther... 13 | 13
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 12 | 12
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 11 | 11
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 10 | 10
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 9 | 9
http://identifiers.org/panther... 8 | 8
http://identifiers.org/panther... 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Proprotein convertase subtilisin/kexin type 6 PCSK6 Tchem Enzyme -2.33983 216.4 239
Short transient receptor potential channel 5 TRPC5 Tchem Ion Channel -2.25002 172.0 220
Amyloid-beta A4 precursor protein-binding family B member 3 APBB3 Tdark Non-IDG -0.61314 4.42 111
Gamma-secretase subunit APH-1B APH1B Tbio Enzyme -1.17035 13.6 56
Neurogenic locus notch homolog protein 3 NOTCH3 Tchem Non-IDG -2.67185 458.4 499
Frizzled-4 FZD4 Tbio GPCR -2.05508 106.8 313
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.96102 8811.6 1442
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.76391 516.8 355
Lymphoid enhancer-binding factor 1 LEF1 Tchem Transcription Factor -2.60971 375.2 591