Development Level

Tbio 146 | 10,625
Tdark 60 | 7,003
Tchem 38 | 1,890
Tclin 6 | 602

Collection

Eligible Kinase Proteins 4 | 134
Eligible non-olfactory GPCR Proteins 2 | 143
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 7 | 633
preweaning lethality, incomple... 5 | 260
abnormal behavior 4 | 226
abnormal bone mineralization 4 | 55
decreased body weight 4 | 174
decreased bone mineral density 4 | 126
decreased lean body mass 4 | 195
decreased total body fat amoun... 4 | 186
abnormal embryo size 3 | 112
abnormal lens morphology 3 | 73
decreased bone mineral content 3 | 157
hydrops fetalis 3 | 22
increased circulating alkaline... 3 | 119
male infertility 3 | 62
short tibia 3 | 82
abnormal bone structure 2 | 131
abnormal eye morphology 2 | 38
abnormal startle reflex 2 | 14
abnormal vocalization 2 | 21
corneal opacity 2 | 25
decreased caudal vertebrae num... 2 | 49
decreased circulating insulin ... 2 | 75
decreased eosinophil cell numb... 2 | 41
decreased prepulse inhibition 2 | 52
decreased startle reflex 2 | 48
embryonic lethality prior to t... 2 | 187
hypoactivity 2 | 89
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
thrombocytopenia 2 | 46
abnormal coping response 1 | 12
abnormal cranium morphology 1 | 32
abnormal eye size 1 | 11
abnormal forebrain development 1 | 18
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 24
abnormal iris morphology 1 | 12
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
cardiovascular system phenotyp... 1 | 35
decreased body length 1 | 108
decreased circulating amylase ... 1 | 24
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating fructosa... 1 | 31
decreased circulating iron lev... 1 | 25
decreased circulating magnesiu... 1 | 11
decreased circulating phosphat... 1 | 15
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased macrophage cell numb... 1 | 4
decreased mean corpuscular vol... 1 | 50
decreased vertical activity 1 | 22
enlarged spleen 1 | 26
impaired glucose tolerance 1 | 52
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating calcium ... 1 | 32
increased circulating creatini... 1 | 29
increased circulating iron lev... 1 | 25
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased circulating thyroxin... 1 | 7
increased eosinophil cell numb... 1 | 9
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased or absent threshold ... 1 | 128
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
increased vertical activity 1 | 18
kinked tail 1 | 3
microphthalmia 1 | 15
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
short snout 1 | 4
shortened ST segment 1 | 9
shortened head 1 | 2
small epididymis 1 | 3
small kidney 1 | 10
small superior vagus ganglion 1 | 20
small testis 1 | 37
straub tail 1 | 26
vertebral fusion 1 | 23

Disease

psoriasis 120 | 6,685
ovarian cancer 115 | 8,484
osteosarcoma 107 | 7,933
Carcinoma 99 | 2,147
medulloblastoma, large-cell 96 | 6,234
glioblastoma 94 | 5,572
atypical teratoid / rhabdoid tumor 85 | 4,369
lung cancer 65 | 4,466
Cancer 63 | 2,346
lung carcinoma 60 | 2,844
Breast cancer 59 | 3,094
primitive neuroectodermal tumor 59 | 3,031
oligodendroglioma 58 | 2,849
ependymoma 54 | 2,514
pilocytic astrocytoma 54 | 3,086
group 4 medulloblastoma 48 | 1,875
malignant mesothelioma 48 | 3,162
pediatric high grade glioma 47 | 2,712
invasive ductal carcinoma 43 | 2,950
lung adenocarcinoma 43 | 2,713
subependymal giant cell astrocytoma 43 | 2,287
non-small cell lung cancer 41 | 2,798
astrocytic glioma 40 | 2,241
intraductal papillary-mucinous carcinoma (IPMC) 40 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,289
interstitial cystitis 37 | 2,299
Pick disease 35 | 1,893
astrocytoma 33 | 1,493
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,956
adult high grade glioma 30 | 2,148
group 3 medulloblastoma 30 | 2,254
pituitary cancer 30 | 1,972
pancreatic cancer 29 | 2,300
sonic hedgehog group medulloblastoma 29 | 1,482
Rheumatoid Arthritis 28 | 1,160
ductal carcinoma in situ 26 | 1,745
cystic fibrosis 24 | 1,665
posterior fossa group A ependymoma 24 | 1,511
breast carcinoma 23 | 1,614
colon cancer 23 | 1,475
medulloblastoma 22 | 1,524
ulcerative colitis 22 | 2,087
Intellectual disability 20 | 573
primary pancreatic ductal adenocarcinoma 20 | 1,271
Multiple myeloma 19 | 1,327
posterior fossa group B ependymoma 18 | 1,530
Colorectal Neoplasms 16 | 217
active Crohn's disease 16 | 918
atypical teratoid/rhabdoid tumor 16 | 1,095
Obesity 15 | 616
adrenocortical carcinoma 15 | 1,427
Osteoporosis 14 | 257
Prostatic Neoplasms 14 | 471
acute myeloid leukemia 14 | 780
juvenile dermatomyositis 14 | 1,189
non primary Sjogren syndrome sicca 14 | 840
spina bifida 14 | 1,064
tuberculosis 14 | 1,557
Schizophrenia 13 | 501
Waldenstrons macroglobulinemia 13 | 765
acute quadriplegic myopathy 13 | 1,157
cutaneous lupus erythematosus 13 | 1,056
esophageal adenocarcinoma 13 | 737
Duchenne muscular dystrophy 12 | 602
autosomal dominant Emery-Dreifuss muscular dystrophy 12 | 499
aldosterone-producing adenoma 11 | 664
gastric carcinoma 11 | 832
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
Mammary Neoplasms 10 | 410
diabetes mellitus 10 | 1,663
Adenoid Cystic Carcinoma 9 | 99
Autistic Disorder 9 | 320
Kidney cancer 9 | 118
tuberculosis and treatment for 3 months 9 | 327
active ulcerative colitis 8 | 477
dermatomyositis 8 | 933
fibroadenoma 8 | 557
primary Sjogren syndrome 8 | 789
urothelial carcinoma 8 | 318
Acquired metabolic disease 7 | 267
Alzheimer's disease 7 | 644
Atopic dermatitis 7 | 944
Bipolar Disorder 7 | 266
Coffin-Siris syndrome 7 | 17
Crohn's disease 7 | 304
Endometriosis 7 | 535
Melanoma 7 | 261
Parkinson's disease 7 | 364
progressive supranuclear palsy 7 | 674
sarcoidosis 7 | 358
Adenoma 6 | 165
Asthma 6 | 349
Hypotrichosis 6 | 29
Multiple Sclerosis 6 | 498
Stomach Neoplasms 6 | 282
adrenocortical adenoma 6 | 134
head and neck cancer 6 | 270
interstitial lung disease 6 | 291
Myocardial Ischemia 5 | 169
nephrosclerosis 5 | 329

Tissue

Digestive Tract 250 | 18,473
Female tissues 250 | 18,647
Urinary Tract 250 | 18,444
Endocrine System 249 | 18,512
Liver and Pancreas 249 | 18,136
Nervous System 249 | 18,561
Blood and immune system 248 | 17,995
Male tissues 248 | 17,969
Skin and soft tissues 248 | 18,115
Cardiovascular System 247 | 17,958
Respiratory system 247 | 17,484

Target Family

Non-IDG 171 | 11,971
Kinase 21 | 634
Enzyme 18 | 4,146
GPCR 13 | 406
Transcription Factor 12 | 1,400
Epigenetic 10 | 242
Ion Channel 3 | 341
TF/Epigenetic 2 | 38

PathwayCommons: panther Pathway

Wnt signaling pathway 250 | 250
Inflammation mediated by chemo... 187 | 187
Integrin signalling pathway 156 | 156
Cadherin signaling pathway 147 | 147
Angiogenesis 141 | 141
Heterotrimeric G-protein signa... 124 | 124
Huntington disease 113 | 113
PDGF signaling pathway 113 | 113
EGF receptor signaling pathway 109 | 109
Heterotrimeric G-protein signa... 105 | 105
Apoptosis signaling pathway 100 | 100
FGF signaling pathway 99 | 99
Alzheimer disease-presenilin p... 97 | 97
TGF-beta signaling pathway 88 | 88
Interleukin signaling pathway 86 | 86
Parkinson disease 82 | 82
untitled 79 | 79
Cytoskeletal regulation by Rho... 70 | 70
Ras Pathway 69 | 69
Nicotinic acetylcholine recept... 62 | 62
T cell activation 60 | 60
Alzheimer disease-amyloid secr... 56 | 56
Metabotropic glutamate recepto... 54 | 54
VEGF signaling pathway 54 | 54
B cell activation 52 | 52
PNAT 52 | 52
Toll receptor signaling pathwa... 44 | 44
Ubiquitin proteasome pathway 43 | 43
Ionotropic glutamate receptor ... 42 | 42
Transcription regulation by bZ... 42 | 42
p53 pathway feedback loops 2 42 | 42
Muscarinic acetylcholine recep... 41 | 41
Thyrotropin-releasing hormone ... 41 | 41
p53 pathway 39 | 39
Blood coagulation 38 | 38
Muscarinic acetylcholine recep... 38 | 38
PI3 kinase pathway 38 | 38
FAS signaling pathway 37 | 37
GABA-B_receptor_II_signaling 35 | 35
Angiotensin_II-stimulated_sign... 34 | 34
Oxytocin receptor mediated sig... 31 | 31
p38 MAPK pathway 31 | 31
5HT2 type receptor mediated s... 30 | 30
Axon guidance mediated by netr... 30 | 30
Cortocotropin releasing factor... 30 | 30
Heterotrimeric G-protein signa... 30 | 30
Insulin/IGF pathway-mitogen ac... 29 | 29
Interferon-gamma signaling pat... 29 | 29
Metabotropic glutamate recepto... 29 | 29
General transcription regulati... 28 | 28
Nicotine pharmacodynamics path... 28 | 28
5HT1 type receptor mediated s... 27 | 27
Notch signaling pathway 27 | 27
Histamine H1 receptor mediated... 26 | 26
Adrenaline and noradrenaline b... 25 | 25
De novo purine biosynthesis 25 | 25
Alpha adrenergic receptor sign... 23 | 23
Endogenous_cannabinoid_signali... 23 | 23
Metabotropic glutamate recepto... 23 | 23
Oxidative stress response 23 | 23
Insulin/IGF pathway-protein ki... 22 | 22
Synaptic_vesicle_trafficking 21 | 21
p53 pathway by glucose depriva... 21 | 21
Hedgehog signaling pathway 19 | 19
Axon guidance mediated by Slit... 18 | 18
DNA replication 18 | 18
Axon guidance mediated by sema... 17 | 17
Beta1 adrenergic receptor sign... 17 | 17
Enkephalin release 17 | 17
Glycolysis 17 | 17
5HT4 type receptor mediated s... 16 | 16
Hypoxia response via HIF activ... 16 | 16
Opioid proenkephalin pathway 16 | 16
Opioid proopiomelanocortin pat... 16 | 16
Plasminogen activating cascade 16 | 16
General transcription by RNA p... 15 | 15
JAK/STAT signaling pathway 15 | 15
Cell cycle 14 | 14
5HT3 type receptor mediated s... 13 | 13
Beta3 adrenergic receptor sign... 11 | 11
Cholesterol biosynthesis 11 | 11
De novo pyrimidine deoxyribonu... 10 | 10
De novo pyrimidine ribonucleot... 10 | 10
Heme biosynthesis 10 | 10
Pyrimidine Metabolism 10 | 10
Vasopressin synthesis 10 | 10
Beta2 adrenergic receptor sign... 9 | 9
Circadian clock system 9 | 9
Fructose galactose metabolism 9 | 9
Histamine H2 receptor mediated... 9 | 9
Salvage pyrimidine ribonucleot... 9 | 9
TCA cycle 9 | 9
Androgen/estrogene/progesteron... 8 | 8
Pentose phosphate pathway 8 | 8
Pyruvate metabolism 8 | 8
Nicotine_degradation 7 | 7
5-arachidonylglycerol_biosynt... 6 | 6
Coenzyme A biosynthesis 6 | 6
Mannose metabolism 6 | 6
P53 pathway feedback loops 1 6 | 6

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Frizzled-7 FZD7 Tbio GPCR -1.70812 55.9 303
Low-density lipoprotein receptor-related protein 5 LRP5 Tbio Non-IDG -3.06756 1202.0 278
Casein kinase I isoform epsilon CSNK1E Tchem Kinase -1.76876 60.7 272
Catenin alpha-1 CTNNA1 Tbio Non-IDG -1.91334 73.6 399
Cadherin-19 CDH19 Tdark Non-IDG -0.58418 4.04 107
Protocadherin alpha-C1 PCDHAC1 Tdark Non-IDG 1.66 33
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 GNB2 Tbio Non-IDG -0.43889 2.98 102
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 GNB1 Tbio Non-IDG -1.15715 18.1 144